癲癇為常見之神經疾病，發作過程中容易造成患者全身性痙癴甚至導致猝死。因此近十年針對如何抑制癲癇的治療方式投入研究，深腦電刺激為其中之一，已有許多動物及臨床實驗證實可有效舒緩或抑制癲癇發作。近年協調復位電刺激被提出，此刺激法原先是針對帕金森病進行研究，其模擬結果與臨床試驗證實可有效解決帕金森患者發病的現象，然而目前並無應用在癲癇之研究，而因為癲癇與帕金森發病模式相似，因此本研究假說協調復位電刺激為癲癇抑制有效方法，研究目的為由小鼠動物實驗驗證協調復位電刺激抑制癲癇之效果。
首先以海藻酸誘發小鼠急性癲癇發作，在大腦CA3區施以隨機非同步協調復位電刺激和多點同步θ頻率波間歇性電刺激，同時記錄腦電圖及小鼠行為，接著利用時頻分析、樣本熵、帶功率判斷每次實驗抑制癲癇之成效，以及比較兩種方法之差異。實驗結果顯示隨機非同步協調復位電刺激法比多點同步θ頻率波間歇性電刺激更好，前者在刺激過程中可有效地舒緩癲癇發作，而刺激結束後可使癲癇完全停止。後者雖可在刺激過程中舒緩癲癇發作，但刺激結束後反而有可能造成癲癇加劇。隨機非同步協調復位電刺激法有可能發展為抑制癲癇的新治療方法。

Epilepsy is a common neurological disease, which can easily lead to systemic convulsions and even sudden death. Therefore, in the past ten years, researchers have been devoted to the treatments of epilepsy and deep brain electrical stimulation is one of them. Animal and clinical experiments have confirmed that deep brain stimulation is effective in relieving epileptic seizures. In recent years, a new stimulation technique called the coordinated reset stimulation (CRS) has been proposed for treating Parkinson's disease. The simulation results and clinical trials have confirmed that it is an effective treatment for Parkinson's disease. However, there is no application of CRS in epilepsy research and due to epilepsy and Parkinson's disease have similar patterns, this study hypothesized that coordinated reset stimulation is an effective method for suppression of epilepsy.
Acute epileptic seizures were induced in mice using kainic acid, random coordinated reset stimulation (RCRS) and multi-point theta-burst stimulation (MTBS) were then applied to the CA3 area of the brain. EEG and mouse behavior were recorded at the same time. The sample entropy and band power of the depth EEG were employed to evaluate the effectiveness of the two methods in suppressing epilepsy. The experimental results show that RCRS is better than MTBS. The former could effectively relieve epileptic seizures during the stimulation process, and could stop the epilepsy completely after the stimulation. Although the latter could relieve epileptic seizures during the stimulation process, it may induce epilepsy again after the stimulation. RCRS may have the potential to become a new therapeutic approach to suppression of epilepsy.

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