本研究成功利用微機電製程技術開發出尿液檢體前處理晶片，以降低尿液中離子雜訊干擾，並配合微型幫浦來發展出可攜式之尿液檢體前處理系統平台。
研究方向是利用電吸附原理進行離子吸附，降低尿液中之離子濃度；前處理晶片設計方面，下層ITO電極晶片與中間層PDMS微流道透過表面改質後，使兩者緊密結合，並於上層使用PMMA與雙面黏性材料做為封裝層，並在前處理晶片後端設計ㄧ對感測電極，以量測尿液之阻抗値變化，再透過微型幫浦做為尿液檢體於晶片內之驅動力來源，即完成尿液前處理晶片，適合短時間操作以及小量批次處理之用。
研究中，使用田口方法進行前處理晶片效能最佳化實驗，以不同前處理電壓(0.2V、0.5V及0.8V)、不同前處理時間(2 min、5min及10 min)、不同ITO薄膜面積(42 mm2、56 mm2及70 mm2)及不同交流電掃頻頻率(100k Hz、125k Hz及150k Hz)進行PBS溶液阻抗變化之探討。經由實驗結果發現，在處理電壓0.8V、處理時間10 min、ITO薄膜面積70 mm2及頻率125k下，PBS溶液阻抗變化率可提高12.5%，品質損失降低5.5%；並使用人工尿液進行驗證實驗，其阻抗提升率達到11.47%，由此可知本研究所開發之前處理晶片適用於臨床檢測上進行尿液前處理之功用。 
最後，本研究成功結合微機電製程技術與生物電阻抗分析技術來完成可拋棄式尿液前處理晶片，晶片尺寸為76 mm × 26 mm × 5 mm，並結合微型幫浦以驅動尿液檢體於晶片中之動力來源，開發出ㄧ簡易平台。

This thesis presents the key factors reducing the concentration of ions in the human urine, and improving the interference of application for bio-electrical impedance analysis (BIA). The combination with urine pretreatment chips and alternative current impedance spectroscopy (ACIS) by instrument of LCR meter were successfully proved that using pretreatment chips is useful to reducing the concentration of ions in the urine. For Taguchi method, when we used 0.8 V voltage, 10 minute reaction time, 70 millimeter square of reaction area, 125k measuring frequency, the impedance increasing efficiency can be increased by 12.5%, and S/N ratio increased to 24.33 dB. After optimization, we used blank urine to verify the clinical function of sample pretreatment chips, the impedance increasing efficiency of urine increased 11.47%, and standard deviation (SD) was 0.66, and coefficient of variation (CV) was 5.73%.

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