日漸減少的天然化石資源驅使以生質廢棄物和能源作物來轉換產生燃料。然而，環顧全球，生質燃料的製造與日增長，同時也受到正面及負面的關注。
於本研究中採用最佳化模式來評估生質酒精推廣政策於區域的永續性之潛在影響。換言之，評估區域的生產力以及自給自足(包含食物、動物飼料及氮肥料)之改變，於市場機制下假設土地利用之改變，並考慮有限的土地及水資源的競爭。本研究提出三項方法來達到未來生質酒精之需求，敘述如下：1) 利用未被使用的料源，如農業廢棄物，2) 提供更多土地供能源作物生長以生產酒精，3) 藉由高生質產量的作物品種來提升土地之生產率。以上各方法皆會導致區域之土地利用及水資源之改變。
於模式中，目標式為收益最大化，並利用能源、食物、動物飼料及氮肥料之供給與需求關係，進一步決定設計變數─土地利用。因此，本研究之個案採用台南地區，該區提供台灣農產品及來自高科技產業之收入，並有約一百八十七萬之人口。
結果顯示可滿足未來2025年E10(以體積比90%汽油與10%無水酒精之混合燃料)之需求，並維持四項自給自足率(self-sufficiency rate)，包含食物、水、動物飼料及氮肥料皆可大於等於1，但農業廢棄物及休耕土地之利用是必要的。同時也觀察到由產生農產品轉移至食物及燃料或甚至只產生燃料的土地利用改變，於豐水與枯水條件下，土地利用轉移也有不同的分配以生產生質酒精。其中，動物飼料及氮肥料為重要之限制式。於枯水條件下，水資源的可及性成為另一重要之限制式，影響收益及土地利用之分配，但系統仍能維持生質酒精之供應藉由減少產生農產品，利用本研究所建構的最佳化模式，可評估於未來酒精供應政策下對於台南地區造成之永續性影響。

Increasing scarcity of natural fossil resources drives utilization of residual biomass and energy crops to generate biofuels. However, the increasing biofuel production around the world has been attracting both positive and negative attentions.
In this study, prospective influences of a bio-ethanol promotion policy on regional sustainability are evaluated using an optimization model. Namely, the productivity of the region and the change in self-sufficiency (food, feed and nitrogen fertilizer) associated with future bio-ethanol demand is analyzed assuming occurrence of changes in land use under market mechanisms, considering competition over productive land and water supply. Bio-ethanol demand in the future is met by: 1) using unutilized feedstock, e.g. agricultural residue, 2) preparing more land for crops that provide feedstock for ethanol production, and 3) increasing productivity of land e.g. by using high biomass yielding cultivars. All the three approaches induce changes in regional land use and water consumption. To determine the land use as design variables, the model uses supply and demand relationship with respect to energy, food, feed, and nitrogen fertilizer, with an objective of profit maximization. Use of this model is demonstrated with a case study on Taiwanese national policy on promotion of bio-ethanol with focus on a region in the south of Taiwan, that provide both food and income from high-tech industries for the nation, as well as houses for population of 1.87 million.
 
The result indicated that the prospective E10 (i.e., hybrid fuel with gasoline 90%, anhydrous ethanol 10% by volume) demand in 2025 is met maintaining the four regional self-sufficiency rates (SSRs) at above 1.0, but the use of agricultural residue and the use of fallow land are necessary. The shifts of land use from food production to combined food and fuel production or even to fuel production only are observed. This shift occurs in different patterns under abundant water supply and drought conditions over varied bioethanol production. The feed and nitrogen fertilizer SSRs are the key constraints. Under drought condition, water availability emerges as another important constraint affecting the income and thus the allocation of land use: as a result the region maintains ethanol supply by reducing food production.

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