本篇論文提出一個可以連續分離多種不同尺寸粒子的微流體粒子連續分離系統。此系統設計一微流道結構及流場，並結合DPE建立的光場，使得不同尺寸的粒子透過微流體中拖動力及光場梯度力的差異而可被導至不同的微流道而分離。
本論文運用流體力學概念設計微流道、並依此設計相配合之光場場型，論文中使用了傅立葉繞射光學理論輔以模擬軟體Matlab模擬繞射相位元件(Diffractive Phase Elements, DPE)與其建立之光場，並以有限元素法計算微流道之流場，最後結合兩者，計算出六種不同尺寸粒子在流體中的受力軌跡圖，以驗此微流體連續分離系統可連續分離多種不同尺寸之粒子。

This dissertation proposes a system which can sort multi-sized particles successively. This system includes a micro-channel structure, flow field, and light field which is set up by Diffractive Phase Elements (DPE). This system combines the gradient force of light field and the drag force of flow field to separate multi-sized particles to different branch channels to achieve the purpose of particle sorting.

[1] 盧奕宇,“光渦流雷射陣列光鉗系統於微流體中之分析與應用”,國立成功大學物理研究所碩士論文 (2013).
[2] D. Cojoc, S. Cabrini, E. Ferrari, R, Malureanu, M. B. Danailov, E. Di Fabrizio, “Dynamic multiple optical trapping by means of diffractive optical elements,” Microelectronic Engineering 73-74, 927-932 (2004).
[3] 許詠盛,“Fourier Optics 傅立葉光學”,網路資料.
[4] 國立成功大學物理系朱淑君教授傅立葉光學講義.
[5] 王修辭,“多焦點繞射式光學元件之設計”,國立中央大學光電科學研究所碩士論文 (2002).
[6] 張耿維,“純相位繞射光學元件的設計並以液晶空間光調制器實現之”,國立中央大學光電科學研究所碩士論文 (2005).
[7] D. Wang, J. Zhang, H. Zhang, “Adaptive-weight iterative algorithm for flat-top laser beam shaping,” Optical Engineering 51(7), 074301 (2012).
[8] F. Wyrowski, “Diffractive optical elements: iterative calculation of quantized, blazed phase structures,” Journal Optical Society America 7, 6 (1990).
[9] Y. Harada, T. Asakura, “Radiation forces on a dielectric sphere in the Rayleigh scattering regime,” Optics Communications 124, 529-541 (1996).
[10] 鍾玉堆,許源鏞,許世卿,劉張源,王鴻烈,溫家俊,“流體力學概論”,大揚出版社, Chapter 4 (1994).
[11] 鄭福田,劉希平,“微粒導論”,華泰文化, Chapter 4, Chapter 5 (2001).
[12] D. L. Ermak and J. A. Mcammon, “Brownian Dynamics with Hydrodynamic Interactions,” The Journal of Chemical Physics 69,1352-1360 (1978).
[13] 曾相文,“以有限元素法分析凝固熱傳問題”,國立成功大學工程科學所碩士論文 (2013).
[14] 張宇良,“利用有限元素法求解相變化熱傳問題”,國立成功大學工程科學所碩士論文 (2012).
[15] R. W. Applegate Jr., J. Squier, T. Vestad, J. Oakey, D. W. M. Marr, P. Bado, M. A. Dugan and A. A. Said,“Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping,” Lab Chip 6,422-426 (2006).
[16] E. R. Dufresne, G. C. Spalding, M. T. Dearing, S. A. Sheets and D. G. Grier, ”Computer-Generated Holographic Optical Tweezer Arrays,” Rev.Sci.Instrum.72,1810 (2001).