本研究的主要目的在於探討利用共溶劑的添加以促進陰陽離子液胞的自發性形成。本文中使用了九種直碳鏈的陰/陽離子型界面活性劑混合系統：CnSO4NaCmN(CH3)3Br; n = 12, 14; m = 8, 10, 12, 14; 及 C12SO4NaC16N(CH3)3Br。陰/陽離子型界面活性劑的莫耳比例皆為1：1，陰/陽離子型界面活性劑系統總濃度固定為10 mM。搭配了四種共溶劑：甲醇、乙醇、正丙醇及正丁醇。液胞的自發性形成主要是根據粒徑的分布及肉眼觀察的綜合判斷，並以TEM的顯微觀測作為輔助。
　　實驗結果顯示，添加共溶劑對液胞形成的效應，隨著陰/陽離子型界面活性劑系統、疏水性尾基的總碳數、共溶劑的種類及添加量的不同，會有多樣的變化。經由本文分析其影響效應可以歸納成四種轉變型態：type 1為系統在純水中直接形成液胞溶液，添加共溶劑後液胞則逐漸溶解成單分子。type 2為系統在純水中形成沈澱物，一添加共溶劑，沈澱物則會立即轉變成液胞結構，隨著共溶劑濃度的增加，液胞則逐漸溶解成單分子。type 3與type 2類似，差別在於共溶劑需添加到一極限濃度才能使沈澱物轉變成液胞。type 4為系統在純水中形成沈澱物，添加共溶劑沈澱物則逐漸溶解成單分子。其中type 2及type 3可以有效地促使原本在純水中只形成沈澱物的陰/陽離子型界面活性劑系統轉變生成液胞，這對穩定液胞的獲得及其相關應用極有貢獻。本文並提出疏水效應理論機制，藉由混合溶劑的介電性質的改變，合理解釋實驗的結果。

　　This work aims to provide a practical vesicle-boosting method by means of cosolvent addition in water and propose a theoretical explanation which can delineate the general trend of cosolvent effects and elucidate the possible role of cosolvent in the formation of catanionic vesicles. Effects of four homologous cosolvents (methanol, ethanol, 1-propanol, and 1-butanol) on the spontaneous formation of vesicles from eight 1:1 anionic-cationic mixed surfactant systems sodium alkyl sulfatesalkyltrimethylammonium bromides (CnSO4NaCmN(CH3)3Br; n = 12, 14; m = 8, 10, 12, 14) at a total surfactant concentration of 10 mM were systematically studied. The experimental results revealed that varied changes in vesicle formability of different mixed surfactant systems may be resulted from various kinds and amounts of cosolvent. Four types of cosolvent effects, however, can be classified. Among them, cosolvent effects type 2 and type 3 would serve the purpose and were exemplified by C12SO4NaC10N(CH3)3Br, C14SO4NaC10N(CH3)3Br, and C12SO4NaC12N(CH3)3Br mixed surfactants. Furthermore, the effectiveness of vesicle boosting increases in the order 1-butanol > 1-propanol > ethanol > methanol. An explanation of cosolvent effects based on the medium dielectric constant was then proposed.

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