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研究生: 江嘉駒
Chiang, Chia-Chu
論文名稱: 醫學工程用植入式微壓力感測器
An Implantable Micro Pressure Sensor for Biomedical Engineering Applications
指導教授: 朱銘祥
Ju, Ming-Shaung
林宙晴
Lin, Chou-Ching K.
學位類別: 碩士
Master
系所名稱: 工學院 - 機械工程學系
Department of Mechanical Engineering
論文出版年: 2004
畢業學年度: 92
語文別: 中文
論文頁數: 80
中文關鍵詞: 銬型電極微壓力感測器
外文關鍵詞: cuff electrode, micro pressure sensor
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  •   銬型電極是神經性義肢重要的元件之一。它可用來刺激運動神經元或是紀錄感覺神經元訊號。神經電極植入人體後,當施於神經之壓力大於20mmHg時,會對神經產生不良影響。因此銬型電極與神經介面間的壓力是監測神經健康狀態之重要指標。本研究除了改良先前發展的銬型電極外,並發展整合電容式微壓力感測器的新型電極。
      本研究利用熱處理方式製作出電極金表面凸起的銬型電極,但實驗結果顯示電極表面的凸起或凹陷對於神經訊號的量測雜訊比並無太大的影響。另外,成功製作出一電容式微壓力感測器,其感測電極尺寸為7000m×7000m,量測範圍為0-50mmHg,靈敏度為0.01pF/mmHg。此外,發現感測器中介電層之波松比與遲滯比等特性對感測器是重要的設計參數和絕緣層厚度會影響感測器的電容初始值。

      Cuff electrode is an indispensable component in a neural prostheses system. It is used to stimulate the motor neuron and to record neural signals from the peripheral nerve. It is known that a pressure larger than 20mmHg has a harmful effect to the nerve trunk. Measuring the interface pressure between the cuff and the nerve trunk provides a means to monitor the health of nerve trunk. Therefore, the goals of this study are twofold: first, to improve the measurement performance of cuff electrodes and second, to develop a micro capacitive pressure sensor embedded into the cuff electrode.
      In current study, the fabrication of a cuff electrode with a convex structure on the surface of gold electrode is suggested by using heat treatment. However, experiment result revealed that there is no significant difference in measurement performance between the electrodes with either the convex surface or the concave surface. In addition, a micro capacitive pressure sensor is successfully developed and tested. The dimension of the sensing electrode measured 7000m×7000m; the range of pressure measurement was from 0 to 50 mmHg; and the sensitivity was 0.01 pF/mmHg. It is found design the Poisson’s ratio and hysteresis properties of the dielectric layer has significant effect on sensor design and a thickness of the insulated layer affects the initial capacitance of the pressure sensor.

    中文摘要 i 英文摘要 ii 誌謝 iii 中文目錄 iv 圖目錄 vii 表目錄 xi 符號說明 xii 第一章 緒論 1 1-1 研究背景 1 1-2 文獻回顧 5 1-3 研究動機與目的 8 第二章 方法與實驗 9 2-1 微機電系統技術 9 2-1-1 面型微細加工 10 2-1-2 旋轉塗佈技術 10 2-1-3 光微影和蝕刻技術 12 2-1-4 電子束薄膜蒸鍍技術 14 2-2 銬型電極之改良與動物實驗 15 2-2-1 銬型電極之設計與改良 15 2-2-2 神經電極之動物實驗 17 2-3 壓力感測器之設計 18 2-3-1電容式壓力感測器原理 18 2-3-2電容式壓力感測器之設計 21 2-3-3介電層之研究 23 2-3-4電容量測 25 2-4 整合於銬型電極之壓力感測器製程 27 2-5 PDMS薄膜電漿表面改質處理 29 2-6 壓力感測器之校正 31 2-6-1平面壓力感測器校正 31 2-6-2環型壓力感測器校正 34 2-6-3 動物實驗 36 第三章 結果與討論 37 3-1 神經電極改良結果 37 3-2 神經電極動物實驗結果 39 3-3 壓力感測器微機電製程結果 43 3-3-1 PI顯影與舉離結果 44 3-2-2介電層PDMS薄膜形成結果 47 3-4 電漿表面改質結果 50 3-4-1 電漿參數測定結果 50 3-4-1 表面改質後之結果 52 3-5 感測電路校正結果 53 3-6 水溶液環境對壓力感測器量測之影響 55 3-7 感測器理論模擬結果 56 3-8 壓力感測器校正結果 57 3-8-1 平面壓力感測器校正結果 57 3-8-2 環型壓力感測器校正結果 62 3-8-3 動物實驗 63 3-9 討論 64 3-9-1 神經電極動物實驗 64 3-9-2 壓力感測器製程 65 3-9-3 壓力感測器絕緣層與環境影響 67 3-9-4 壓力感測器性能分析 70 3-9-5 壓力感測器環型校正與動物實驗 73 第四章 結論與建議 74 4-1 結論 74 4-2 建議 76 參考文獻 77

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