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研究生：	吳淑華 Wu, Shu-Hua
論文名稱：	非平面動脈流場之計算研究 The Computations for Non-Planar Arterial Bypass
指導教授：	李定智 Lee, Denz
學位類別：	碩士 Master
系所名稱：	工學院 - 航空太空工程學系 Department of Aeronautics & Astronautics
論文出版年：	2006
畢業學年度：	94
語文別：	中文
論文頁數：	84
中文關鍵詞：	剪應力、非平面、部分阻塞、數值模擬、繞道管、吻合術、內膜增生、血液動力學
外文關鍵詞：	Hemodynamics, Intimal hyperplasia, Non-planar, Wall shear stress, Numerical simulation, Parallel computing, Stenosis, Anastomosis, Bypass
相關次數：	點閱：126 下載：1
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　　動脈繞道手術是目前臨床上在治療阻塞性的主動脈病變時普遍應用且有效的方法之一。然而，其長短期的成功率一直無法有效地提高，短期上由於血栓形成，長期上則肇因內膜增生，以致最後必須再重複接受手術治療。
　　本研究延續已完成的繞道管穩態流場先導研究及可行性評估，採用有限體積法以數值模擬方式探討動脈血管繞道模型之整體流場，以瞭解血液動力學在誘發內膜增生—繞道手術失敗最主要的原因—時所扮演的角色。主要特點在於探討完整繞道管系統的流場，即同時包含其分歧與匯流兩個吻接處以及考慮繞道管曲率對流場所造成的影響。
　　在本研究中，首先針對相同管徑、固定插接角度（45°）、主管中段部份阻塞的物理問題，進一步加上繞道管的三維特徵，藉由在繞道管的兩吻接處間引進一扭轉角度，形成一非平面繞道管結構，並完成非平面繞道管結合主管部份阻塞外型的流場探討，其重點則在於分析其流場特性的影響，接著將分析結果與平面繞道管、主管部份阻塞的外型作比較，期能藉此探討繞道管幾何特徵與主管阻塞處流場之間的相互影響關係。

　　Graft-bypass surgery is at present a routine and effective revascularization procedure for occlusive arterial diseases. However, the long-term success of vascular grafts is often limited by the progression of intimal hyperplasia.
　　The present project is based on the preliminary numerical study of the steady flow field in a complete bypass tube. In order to better understand the role of hemodynamics in the development of intimal hyperplasia, a finite volume method is adopted to investigate the flow field in a representative human femoral bypass system. The main characteristic of the research lies in the fact that a complete bypass system is considered, that is, to include both the proximal and distal anastomosis junctions and to consider the effect of graft curvature on the flow field.
　　In the present study, the steady flow field of a bypass system with a uni-radius, fixed bypass angle(45°), partially occluded at middle site of the host artery and an asymmetric, non-planar bypass graft was investigated. By introducing a twist angle between the two anastomostic junctions of the bypass tube, a three-dimensional , non-planar geometry was obtained. The results were compared with that of the steady flow field of a planar bypass graft. The focus was on the interaction of the three-dimensional characteristic of the bypass graft and the flow field of the partially occluded at middle site of the host artery. Some suggestions to the medical practice could be drawn from the current results.

中文摘要.......................................................Ⅰ
英文摘要.......................................................Ⅱ
誌謝...........................................................Ⅳ
目錄...........................................................Ⅴ
表目錄.........................................................Ⅷ
圖目錄.........................................................Ⅸ
符號說明.......................................................XI

第一章
緒論............................................................1
1.1 簡介......................................................1
1.2 背景......................................................3
1.3 文獻回顧..................................................6
1.4 研究目的.................................................10
第二章
統御方程式與數值方法...........................................11
2.1 統御方程式...............................................11
2.2 座標轉換.................................................13
2.3 數值方法.................................................15
2.3.1 動量方程式之離散化...................................15
2.3.2 動量內插法...........................................17
2.3.3 第一壓力修正方程式...................................19
2.3.4 第二壓力修正方程式...................................20
2.3.5 邊界條件.............................................21
2.3.6 收斂標準.............................................21
2.4 求解程序.................................................22
第三章
格點系統的產生.................................................23
3.1 格點產生.................................................23
3.2 區域式格點法.............................................24
3.2.1 介面處理.............................................24
3.2.2 非平面繞道管.........................................26
3.2.3 阻塞段...............................................27
3.3 計算程序.................................................28
第四章
結果與討論.....................................................30
4.1 基本外型.................................................30
4.1.1 軸對稱的栓塞外型.....................................31
4.1.2 非對稱栓塞的外型.....................................31
4.2 流場中的參數.............................................32
4.3 非平面繞道管、主管部分阻塞之面積縮減模型.................33
4.3.1 速度部份.............................................33
4.3.2 壁面剪應力...........................................34
4.3.3 分流率和迴流區.......................................36
4.4 非平面繞道管、主管部分阻塞之非對稱栓塞模型...............37
4.4.1 速度部份.............................................37
4.4.2 壁面剪應力、分流率和迴流區...........................38
4.5 與平面繞道管、主管部分阻塞模型作比較.....................38
4.5.1 相同點...............................................38
4.5.2 相異點...............................................39
第五章
結論...........................................................43
5.1 重點回顧與結論...........................................43
5.2 建議.....................................................48
參考文獻.......................................................50
表.............................................................61
圖.............................................................58

                                    

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校內：2007-08-18公開
校外：2007-08-18公開

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