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研究生: 施雅蘭
Shih, Ya-Lan
論文名稱: 台灣文化中末期癌症病人臨終症狀之探討
Clinical signs and symptoms on end-of-life for terminally ill cancer patients in Taiwanese culture
指導教授: 趙可式
Chao, Co-Shi
學位類別: 碩士
Master
系所名稱: 醫學院 - 護理學系
Department of Nursing
論文出版年: 2012
畢業學年度: 100
語文別: 中文
論文頁數: 100
中文關鍵詞: 末期癌症病人臨終症狀預估生命存活期臨死覺知
外文關鍵詞: terminally ill cancer patients, signs and symptoms on end-of-life, Estimated life survival, death awareness
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  • 「壽終正寢」、「落葉歸根」是台灣文化根深蒂固的觀念,預估生命存活期有助於醫療團隊了解病人及家屬的餘生期待,以便作完整的善終準備。本研究於南部某醫學中心以立意取樣,藉由病歷回顧的方式,依循經由廣泛性文獻查證,再參照臨床實務經驗,所擬定的「臨終症狀及臨死覺知評估表」作為研究工具,收集癌末病人臨終症狀、臨死覺知與其死亡時間,藉此探討台灣文化中末期癌症病人臨終症狀。
    研究結果發現,總樣本數為121位末期癌症病人,死亡地點在安寧病房者占57.9%,提前回家22.3%,留一口氣回家19%,病人平均年齡63.1歲(SD=14.1),Palliative Prognostic Index(PPI)平均值為11.2,每位病人平均出現7.6種臨終症狀。臨終症狀發生率由高至低依序為:發紺冰冷(98.3%),至死亡日平均3.4天;鏡面舌(93.4%),至死亡日平均8.5天;耳垂縮(93.4%),至死亡日平均5.6天;陳氏呼吸(91.7%),至死亡日平均0.53天;煩躁不安(78.5%),至死亡日平均7.7天;死前嘎嘎聲(Death rattle)(65.2%),至死亡日平均0.89天;陰莖(囊)縮(54.4%),至死亡日平均10.1天;末期躁動(37.1%),至死亡日平均9.9天;鞏膜水腫(33.1%),至死亡日平均10.1天;譫妄(28.9%),至死亡日平均9.4天;夢到過世親人(11.5%),至死亡日平均11.4天。死亡當天意識清醒者占7.4%;嗜睡占6.6%;木僵占18.1%,半昏迷占48.7%,昏迷占19%。臨死覺知的內容有:(1).病人自己感覺來日不多(71.1%),至死亡日平均7.3天;(2).死亡準備交代(64.5%),至死亡日平均8.1天;(3).想回家(45.5%),至死亡日平均9.2天。99.2%臨終病人淋巴球指數低於正常,此平均值為5.3%,至死亡日平均4.7天。預估生命存活期若能參照臨終症狀和臨死覺知發生率,則更能精準掌握以「日」計算之存活預估。
    本研究結果提供實證基礎,可作為末期照護的背景知識藉此提升照護知能,以便更準確地預估病人死亡時日,以利病人及其家屬作善終準備,減少生死兩不安,提升末期病人之照護品質。

    Introduction:
    In Taiwan "to pass away peacefully" is an important and meaningful concept for traditional culture, and people hope to take last sleep at home near end of life. If health care professional can not estimate life expectancy precisely, family goes mad with grief and feels guilty. Besides, health care professional are also frustrated due to the event. So it is a major objective to estimate life expectancy precisely for us.

    Materials and Methods:
    This study was performed through charts review, and collected terminal cancer patients dying symptoms, death awareness and dead time for analysis. We tried to search literatures, accumulate clinical experience, find our knowledge gap, and set up ”the scale of end-of-life signs and symptoms and death awareness” as our tool. Data collection was total 14 months from Dec. 2010 to Feb. 2012, and we enrolled 121 terminal cancer patients in a southern medical center. We used the scale to assemble end-of-life signs and symptoms, death awareness and dead time to discover “the concepts of terminal patients end-of-life signs and symptoms in Taiwan".

    Results:
    We found that the choice of death place was 57.9% at hospice, 41.3% at home from 121 terminal cancer patients. The mean age was 63.1 years (SD=14.1), and the mean Palliative Prognostic Index (PPI) was 11.2. There were 7.6 dying symptoms per patient. The incidence of dying symptoms was 98.3% cold and cyanosis (average 3.4 days to death), 93.4% mirror-like tongue (average 8.5 days to death), 93.4% earlobe shrinking (average 5.6 days to death), 91.7% Cheyne-stokes respiration (average 0.53 days to death), 78.5% restlessness (average 7.7 days to death), 65.2% death rattles (average 0.89 days to death), 54.4% penis shrinkage (average 10.1 days to death), 37.1% terminal agitation (average 9.9 days to death), 33.1% turbid sclera with edema (average 10.1 days to death), 28.9% delirium (average 9.4 days to death), 11.5% Dream of dead relatives and friends (average 11.4 days to death). Death awareness could be divided to: (1). 71.1% patients felt close to death (average 7.3 days to death), (2). 64.5% a preparation to death (average 8.1 days to death),(3). 45.5% patients hoped to go home (average 9.2 days to death). The lymphocyte count in 99.2% end of life patient was lower than normal limit, The mean lymphocyte count was 5.3% (average 4.7 days to death). It will be accurate to estimate life expectancy by observing end-of-life signs and symptoms and death awareness.
    Conclusion::
    The results can provide evidence for clinical practice, offer knowledge and techniques for health care providers, and increase quality of life for terminal cancer patients.
    Key word: terminally ill cancer patients、signs and
    symptoms on end-of-life、 Estimated life survival
    、death awareness

    摘 要 I Abstract II 致謝 IV 目 錄 VI 表 目 錄 VIII 圖 目 錄 IX 第一章 緒論 1 研究背景與動機 1 第二節 研究目的 3 第三節 研究問題 3 第四節 名詞操作性定義 3 第二章 文獻查證 5 第一節 預估生命存活期的重要性 5 第二節 不同種類疾病病人之存活期 12 第三節 預估末期癌症病人生命存活期之評估量表 14 第四節 末期癌症病人的臨終症狀 26 第三章 研究方法 32 第一節 研究設計 32 第二節 研究對象與場域 32 第三節 研究工具的信效度 32 第四節 資料收集 33 第五節 資料分析 35 第六節 研究倫理考量 35 第四章 研究結果 36 第一節 研究對象人口學資料特性 36 第二節 臨終症狀發生率及其至死亡日數 40 第三節 臨終病人的意識狀態 43 第四節 主客觀臨終症狀第一次出現時間 48 第五節 臨終症狀出現數目 60 第六節 臨死覺知之內容 62 第五章 討論 63 第一節 研究優勢 63 第二節 研究限制 63 第三節 研究與文獻比較 64 第四節 研究應用 68 第六章 結論 77 參考文獻 78 中文參考文獻 78 英文參考文獻 82 附錄 87 附錄一 臨終症狀與生命存活期預估文獻文獻整理一覽表 87 附錄二 癌症末期病人臨終症狀及臨死覺知評估表 93 附錄三 病人基本資料表 94 附錄四 「如何陪伴摯愛的親人離世」護理指導衛教單張 95 附錄五 GCP通過證書及臨床研究教育通過證明 99 附錄六 同意臨床試驗同意書 100 表 目 錄 表2-1 KPS量表-Karnofsky Performance Status Scale 15 表2-2 ECOG量表-Eastern Cooperative Oncology Group 17 表2-3 CPS量表- Cancer Prognostic Score 18 表2-4 PaP量表-Palliative Prognostic Score 20 表2-5 PaP量表-預測存活30天的機率-Palliative Prognostic Score Scale 21 表2-6 PPI量表-Palliative Prognostic Index 22 表2-7 PPI量表預測存活天數- Palliative Prognostic Index 23 表2-8 PPS量表-Palliative Performance Scale 24 表4-1 人口學資料特性 37 表4-2 臨終症狀發生率及其至死亡日數 41 表4-3 臨死覺知發生率及其至死亡日數 42 表4-4 臨終病人的意識狀態 43 表4-5 客觀無法處置之臨終症狀第一次出現時間 49 表4-6 可觀察到的客觀症狀,可處置之臨終症狀第一次出現時間 50 表4-7 客觀可處置之臨終症狀-煩躁不安與發生死前日數二次之病例 52 表4-8 病人主觀發生之臨終症狀及出現的時間 53 表4-9 病人主訴可處置之狀態及第一次出現時間 56 表4-10 病人的主訴可處置症狀(死前日數)~想要回家與發生死前日數二次之病例 58 表4-11 臨終症狀發生數目-1 60 表4-12 臨終症狀發生數目-2 60 表4-13 淋巴球指數分佈 61 圖 目 錄 圖2-1 不同種類疾病病人的疾病軌線圖 13 圖2-2 預估病人的病情進展 14 圖3-1 資料收集流程 34 圖4-1 人口學資料特性-年齡 38 圖4-2 人口學資料特性-婚姻、教育 38 圖4-3 人口學資料特性-宗教及對其之影響 38 圖4-4 人口學資料特性-診斷 39 圖4-5 人口學資料特性-癌症轉移 39 圖4-6 人口學資料特性-死亡地點 39 圖4-7 臨終前意識清醒之天數 44 圖4-8 臨終前意識嗜睡之天數 45 圖4-9 臨終前意識木僵之天數 45 圖4-10 臨終前意識半昏迷之天數 46 圖4-11 臨終前意識昏迷之天數 46 圖4-12 死亡當天意識之狀態 47

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