在有機合成中，過渡金屬鹽類作為催化劑進行自由基反應合成多環類化合物，已是常見的有效途徑。鈷金屬鹽類相較於其他過渡金屬鹽類有便宜易取得與毒性較低的優點，在本篇我們將探討以鈷催化進行自由基環合反應合成深具醫藥開發價值的2-喹啉酮類衍生物。
本篇論文分為兩個部分：第一部分是利用乙醯丙酮鈷(II)作為催化劑，催化乙醯胺類化合物進行分子內自由基環合反應，合成2-喹啉酮類化合物；第二部分則是利用醋酸鈷(II)與乙醯胺類化合物進行自由基反應，合成相對應之2-喹啉酮類化合物。

According to the literatures, transition metal salts were known to catalyze free radical reactions for the synthesis of polycyclic compounds. Compared with other transition metal salts, cobalt salts are easily available and have the advantages such as low costs and relatively low toxicity. In this thesis, we respectively used cobalt(II) acetylacetonate and cobalt(II) acetate to catalyze the intramolecular radical cyclization reactions of the acetamide derivatives to generate the corresponding 2-quinolinone compounds, and the products were formed in moderate to good yields. From the results, we could learn that the use of cobalt salts involving in free radical reactions is indeed applicable to synthesize 2-quinolinone compounds, and the methods also showed the good tolerance of a broad range of functional groups.

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