油滴是細胞中主要負責儲存脂質的胞器，而近年來的研究結果已經將油滴的功能拓展為適應性胞器而不單只是脂肪儲存，例如:調節脂質含量，防止脂毒性及蛋白質降解，以及抗氧化等。然而對於油滴在癌細胞中的功能性則尚不清楚。在這裡，我們想去探討多元不飽和脂肪酸亞麻油酸，與單元不飽和脂肪酸油酸，是否會在癌細胞中引起油滴累積，以及油滴累積在癌細胞中的功能。本研究結果顯示，在HepG2肝癌細胞中，亞麻油酸與油酸皆會造成大量的油滴累積，且亞麻油酸會抑制癌細胞的生長，而油酸則促進癌細胞的生長。當抑制癌細胞中油滴累積時，會導致癌細胞生長受到抑制。另外，在氧化壓力的實驗中，我們也發現亞麻油酸與油酸所引起的油滴累積具有對抗氧化壓力的作用，進而幫助細胞存活。因此油滴可作為保護癌細胞生長的機制之一。

Lipid droplets (LDs) are the organelles for the storage of lipids in the cell. Recent findings have demonstrated that LDs function as adaptable organelles rather than fat storage. Many studies have shown the multiple functions of LDs, such as regulating cellular lipid content, preventing lipid toxicity as well as protein degradation, and antioxidation. However, the functions of LDs in cancer cells remain unclear. Therefore, we want to investigate whether polyunsaturated linoleic acid (LA) and monounsaturated oleic acid (OA) induce LDs accumulation, and also clarify the roles of LDs in liver cancer cells. The results showed that both LA and OA induced a large number of LDs in HepG2 cells. Meanwhile, LA inhibited but OA promoted HepG2 cell growth. Moreover, when the LDs formation was inhibited, the cell growth was repressed. On the other hand, we also found that the LDs induced by LA or OA had antioxidation effects and could help cells to survive. Thus, LDs can protect cancer cells from oxidative stress-suppressed cell growth.

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