新型抗菌劑-鹵胺類抗菌劑不只具備以往抗菌劑優點，廣譜的抗菌能力，還有低毒性、高穩定性及最重要的再生的特性，能大幅降低一次性抗菌醫材使用的浪費，使其成為近年來研究學者致力於研究的新抗菌材料，故本論文以鹵胺類抗菌劑作為主軸，結合其他特性並且在PET聚酯纖維進行表面改質，開發出再生性抗菌纖維。
本實驗將PET聚脂纖維用澱粉與交聯劑在纖維表面上形成一層高分子膜，作為抗菌表面改質的反應性官能基，並且合成具有長碳鏈四級胺鹽的再生性鹵胺類抗菌劑，利用交聯劑將其接枝在纖維上，而合成之抗菌劑由NMR鑑定其結構，表面改質後的PET聚脂纖維由XPS鑑定表面化學結構，改質基材所使用的是不織布纖維，將參考AATCC Test Method 39的濕潤性測試評估其親疏水性，漂白水氯化後的樣品由碘量法標定氯含量，再由清潔劑、海砂、磁石攪拌清洗樣品後再氯化評估再生性，最後抗菌測試參考修改AATCC Test Method 100之三明治法評估對格蘭氏陽性菌(S. aureus)與格蘭氏陰性菌(E. coli)之抗菌性，
實驗結果顯示只有不含碳鏈的樣品有較高耐久性與氯含量，耐久性測試也是高於含碳鏈之樣品，氯化後對於格蘭氏陽性菌(S. aureus)與格蘭氏陰性菌(E. coli)接觸時間10分鐘就能達到90%以上之抗菌率，再生後之抗菌率也保持在90%左右，呈現出再生性鹵胺類高效抗菌能力，但結合長碳鏈部分仍有待改進，抗菌劑合成設計需做改良，不過以澱粉作為增加反應性官能基的纖維基材前處理卻是可行的，水洗後連接抗菌劑小分子酯類鍵結水解，濕潤性測試結果顯示改質後PET聚酯纖維樣品卻變為非常親水，可見澱粉與BTCA仍穩固鍵結在纖維基材表面。

Extensive works on N-halamine antimicrobial agents has been reported over the past few decades because of their advantages containing long-term stabilities, low toxicities to humans, biocidal activity against a broad spectrum of microorganisms, and rechargeable properties upon exposure to household bleach. Thus, the objective of this study is to combine polyester fibers with N-halamine to develop rechargeable antimicrobial fibers.
In this work, N-halamine compounds terminated with long alkyl chain and quaternary ammonium were synthesized and coated onto starch-treated polyester fibers using polycarboxylic acids as crosslinking agents. The chemical structure of synthesized compounds and surface characterization of modified polyester fibers were analyzed by NMR and XPS respectively. Wettability and antimicrobial efficacy were measured through AATCC Test Method.
Though the formation of ester bonds between polycarboxylic acids and antimicrobial agents hydrolyzed after washing cycles, the functional treatment based on starch and polycarboxylic acids was still stable on the PET fibers which resulted in good wettability . The modified polyester fibers without long alkyl chain was more durable and exhibited antimicrobial activity with inactivation about 90% of S. aureus and E. coli within ten minutes of contact time, even after five washing cycles. However, the ones with long alkyl chain were either non-wettable or had poor antimicrobial efficacy. Thus, there still was a need to improve the design of N-halamine compounds terminated with long alkyl chain.

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