研究背景
精神分裂症會造成患者嚴重的失能，目前對於精神分裂症的治療效果強調不只是症狀的緩解，也包括社會功能的保存及生活品質的維持。另外，生活品質是目前逐漸受到重視的測量健康的計量單位，可用於測量精神分裂症的預後。
研究目的
評估機構內及社區族群之精神分裂症病患在發病後的生活品質，及探討其決定因子，試圖呈現精神分裂症患者生活品質各因子的影響程度。
研究方法
本研究之受試者包含24小時全日住院之精神分裂症患者及社區患者。利用世界衛生組織生活品質問卷-台灣簡明版以及歐洲生活品質問卷測量病患的生活品質。本研究也同時評估社會功能障礙(個人與社會表現量表)、憂鬱情緒(簡式健康量表)、復健活動的參與程度與生活品質之間的關聯性並以多重線性回歸模型探討關聯因子。
結果
WHOQOL-BREF(TW)應用於精神分裂症患者的信、效度已獲得驗證。BSRS-5高得分組的WHOQOL-BREF(TW)生理、心理、社會範疇、EQ-5D的疼痛/不適、焦慮/憂鬱、效用項目分數皆明顯低於低得分組。PSP分數在自我照顧項目與WHOQOL-BREF(TW)的生理範疇有相關。精神分裂症患者的生活品質作主要影響因子為憂鬱情緒，社會功能(職業復健程度、婚姻、教育程度)及年齡亦有相關。
結論
以WHOQOL-BREF(TW)評估精神分裂症病患之生活品質與情緒相關性較大，EQ-5D與個人社會功能的分數有較多相關性，較少受情緒影響。

Background
Schizophrenia is a devastating disease. Current therapeutic concept not only emphasize on the recovery of symptoms, but also the preservation of social function and quality of life. In addition, quality of life is an important index of health measurement which currently attracts more attention in the application of outcome research.
Research Aim
The purpose of this study is to estimate the quality of life and related determinants after illness onset of schizophrenic patients.
Method
Subjects receiving face-to-face interview includes 24-hour hospitalized patients and community patients. The scores of WHO Quality of Life-BREF (TW) and EQ-5D are obtained to determine the quality of life of schizophrenic patients. This study also estimate mood condition (Brief Symptom Rating Scale), social performance (Personal and Social Performance Scale), level of occupational activity and their relation to quality of life. Analysis with multiple linear regressions was conducted to study determinants of QOL domains and items.
Result
The WHOQOL-BREF (TW) is reliable and valid when applied to schizophrenic patients. Patients with high score in BSRS-5 got lower score in physical, psychological, social domains in WHOQOL-BREF (TW) and pain / discomfort, anxiety / depression and utility in EQ-5D. PSP are relevant to WHOQOL-BREF (TW) in psychological domain. The related determinants of Quality of life of schizophrenic patients are mood, social function (marriage status, education level and occupationally rehabilitation) and age.
Conclusion
Quality of life of schizophrenic patients assessing by WHOQOL-BREF (TW) has correlation with mood. EQ-5D is related to the psychosocial performance measured by PSP and are less affected by emotional state.

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