本研究在描述荷蓮豆鹼(Cordatanine)之全合成。在本合成方法裡，我們利用四個步驟的反應，其中探討以氧-甲烷化試劑合成中間產物(E)-ethyl 3-methoxy-3-(9H-pyrido[3,4-b]indol-1-yl)acrylate 102，進而利用空間效應改善D-環的環合產率。不僅有助於抗愛滋藥物的開發並比較其同分異構物的光譜數據。

A total synthesis of Cornatanine (1a) is described. In this synthesis, we achieved four-step sequence, and discussed the O-methylation reagents in synthesis of (E)-ethyl 3-methoxy-3-(9H-pyrido[3,4-b]indol-1-yl)acrylate (102). Improvement of the yield of D-ring cyclilation by steric effect is expected. Besides, this research can aid the pharmaceutical development of anti-HIV and the study of the isomers’ spectra data.

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