動脈壁增厚是動脈粥樣硬化的早期跡象與胸主動脈瘤及栓塞性中風的心血管疾病（Cardiovascular diseases，CVDs）的患病率和發病率有關。基於血液動力學的分析用於特定患者的風險評估是CVDs臨床管理的一種有前途的方法。在影響這些評估的各種因素中，主動脈壁厚度成為重要因素。通過計算流體力學的流固耦合分析（Fluid-Solid Interaction，FSI）模擬不同壁效應的匹配厚度之主動脈模型中脈動性血流與壁面結構力學之間的複雜機械相互作用。這項研究調查主動脈內的流場及速度截面，顯示在心動週期上的壁位移和主動脈有效應力，確定流場速度截面及壁面剪應力，其中在FSI 均勻厚度與剛性壁中的壁面剪應力最大相差比為6.4% - 10.3%，而在 FSI 多變厚度的最大差異比為2.5% - 3.1%，在體外實驗部分架構矽酮主動脈模型流場並計算模型厚度且比較流場可視化模擬與實驗之間的結果，可以觀察到在降主動脈壁面上會有粒子碰撞現象，而後隨流體慣性作用加速至出口處。根據數值模擬及實驗部分提供了對胸主動脈瘤及栓塞型中風的生物力學的病因學見解，壁效應對主動脈模型血液動力學研究可能在臨床上診斷有進一步的貢獻。

Arterial wall thickening is an early sign of atherosclerosis and is related to the prevalence and incidence of thoracic aortic aneurysms and embolic stroke cardiovascular disease (CVD). Among the various factors that affect these assessments, the thickness of the aortic wall becomes an important factor. The complex mechanical interaction between blood flow and wall structure mechanics in the aortic model is simulated by fluid-structure coupling (FSI) and has matching thicknesses with different wall effects. This study investigated the flow field and velocity cross-section within the aorta showed systolic wall displacement and effective aortic stress and determined the flow field velocity cross-section and wall shear stress, where the wall thickness in FSI is uniform for rigid walls. The maximum shear stress difference is 6.4%-10.3%, and the maximum difference in variable thickness in FSI is 2.5%-3.1%. In the in vitro experiment part, the silicone aortic model flow field was established, the thickness of the model was calculated, and the visualization effect of the flow field was compared. As a result, between simulation and experiment, it can be observed that the particles collide on the wall of the descending aorta and then accelerate to the outlet with fluid inertia. According to the numerical simulation and experimental part, it provides biomechanical insights into thoracic aortic aneurysms and embolic strokes. The wall effect may further contribute to the clinical diagnosis of aortic model hemodynamics.

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