人體脊椎因年紀、磨損或其它各種原因導致椎間盤損壞時，椎間盤中髓核（Nucleus Pulposus）可能就會被擠壓而突出穿過纖維外環並壓迫到神經，導致頸背疼痛、上肢麻痛或感覺異常，這種症狀稱為退化性椎間盤疾病（Degenerative Disc Disease，DDD）。治療退化性椎間盤疾病有許多不同之手術方式，而不同的手術方式，均有其相應的生物力學表現。
傳統的椎間盤手術是在椎間盤切除後植入自體骨或人工骨支架，若有多節椎間盤需治療時並輔以鈦合金固定物，以達到「固定」之目的。但該節被固定後，椎間盤活動度會受限制，需由鄰近節之椎間盤增加活動度加以代償，近來有研究發現此種治療方式會造成鄰近節椎間盤壓力增加、活動量增加進而提高「鄰近節病變」的發生率。本研究即是以有限元素模型模擬人工椎間盤或是椎間融合器輔以鈦合金鋼板治療頸椎退化性椎間盤疾病，以期望能達到減低鄰近節負擔之效果，減低鄰近節病變的發生率。
本研究使用電腦斷層掃瞄與有限元素法套裝軟體，建立完整之頸椎模型，取頸椎第二節至頸椎第七節，並對三節椎間盤(IVD C3-4、IVD C4-5、IVD C5-6)以人工椎間盤配合椎間融合器或者是椎間融合器輔以鋼板治療，觀察脊椎在伸展、前彎、側彎、扭轉等四種動作下，整體頸椎之活動度、應力變化，以及對鄰近節之生物力學影響。

Human’s intervertebral disc will degenerate as time goes by. The nucleus pulposus in disc will be crushed and protrudes through the annulus fibrosus and pressure to the Ligament. This disease which called” Degenerative Disc Disease，DDD”.Traditional intervertebral disc surgery is using cage or anterior plate.But generally considere that spinal fusion surgery will cause the degeneration of adjacent segment. So in recent years,the invention of artificial disc attempt to prevent the degeneration of adjacent segment.This research discuss multisegmental cervical degenerative disease treated by artificial disc,cage,and plate.Trying to find case that can reduce the influence of adjacent segment.This research use finite element method to simulate human,and using finite analysis software ABAQUS. All in all,we found that artificial disc in C56
will reduce the influence of adjacent segment,and plate prefer to place at C34. Detailed description in chapter 4.

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