在本研究中，將利用經由氨基官能化改質，平均直徑大小為480nm之雙邊不對稱球體，和表面帶有硫酸根，平均直徑大小為100nm之聚苯乙烯奈米微珠進行共同自組裝。在適當的條件下，4個改質比例為1/3之雙邊不對稱球體竟可以和只有1個聚苯乙烯奈米微珠組裝形成穩定之特殊四面體結構。
　　擁有氨基官能化改質之雙邊不對稱球體，將再進一步在其表面分別嫁接上Atlantic Blue (AB)或是6-[2-(N,N-Dibutylamino)naphthyl]ethenyl-4'-Pyridinium Propane Sulfonate (Di-4-ANEPPS)的螢光染料後，作為螢光共振能量轉移配對中的施體與受體。由於螢光共振能量轉移對距離非常敏感，必須在施體與受體靠的夠進時才會發生。而藉由共同自組裝行為中球體與球體間的接觸，組裝形成各種特殊結構，大幅縮短了施體與受體之間的距離，進而引發了螢光能量共振轉移效果的發生。
雙邊不對稱球體及其組裝過程將透過動態光散射分析儀 (DLS)進行監測，提供顆粒的尺寸分佈和組裝的納米結構的即時資訊。同時，螢光能量共振轉移的訊號也同驗證了施體與受體球體之共同自組裝，四面體結構在水溶液中的布朗運動行為也清晰的透過暗場光學顯微鏡(DFOM)下觀察。本研究同時也針對共組裝之動態行為進行探討，其中包括四面體團簇可逆的拆解行為，利用改變顆粒濃度去影響顆粒重新的組裝時間，以及施體與受體顆粒之間在重新組裝過程中的置換行為。

In this research work, Janus particles cored with 480 nm silica spheres and partially surface-functionalized with amino groups were utilized to co-assemble with sulfate-functionalized polystyrene nanoparticles with an average diameter of 100 nm. Under the desired conditions, four of the Janus particles with the amino-moiety on 1/3 particle surface demonstrated the unique co-assembly with only one polystyrene particle which then formed a stable and well-defined tetrahedron structure, or the tetramer, with four Janus particles on the tetrahedron corners and one polystyrene particle in the center.
Janus particles with amino functionalities were also grafted with the fluorescent dye, such as Atlantic Blue (AB) or 6-[2-(N,N-Dibutyl amino)naphthyl]ethenyl-4'-Pyridinium Propane Sulfonate (Di-4-ANEPPS), served as the fluorescent resonance energy transfer (FRET) donor and acceptor, respectively. These Janus particles with donor or acceptor moieties triggered the distance-sensitive FRET, only when they were very close and co-assembled together with polystyrene particles into the desired nanostructures.
Janus particles and their assembled clusters were directly monitored by the Dynamic Light Scattering analyzer (DLS), where the sizes of particles were determined and the assembled nanostructures were calculated. The fluorescence and FRET signals also evidenced the assembly of donor and acceptor Janus particles. Meanwhile, the Brownian motions of these particles and assembled clusters in an aqueous solution were observed by the Dark Field Optical Microscope (DFOM). The dynamic motion of Janus particle co-assembly was carefully investigated in this study, including the reconfigurable assembly behavior of tetramer clusters, concentration-dependent of re-assembly, and the replacement process between donor and acceptor particles.

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