台灣每年有300至400個唐氏兒出生，但70%至80％的唐氏兒都是由年輕懷孕婦女所生。目前國內於34歲以下的懷孕婦女多採用母血篩檢作為初步篩檢的方式。母血篩檢對於外籍女性配偶而言，可能成為他們第一個碰到的遺傳檢測。在決定是否接受母血篩檢過程中，外籍女性配偶常是藉由先生的解釋，間接獲得母血篩檢的資訊。所以，外籍配偶接受母血篩檢的知情選擇是無法確定的。目前國內缺少關於外籍配偶知情選擇上的研究。本研究之目的是在探索越南籍配偶於母血篩檢之知情選擇上的情況並以台籍婦女作為對照。
本研究採回溯性研究，以方便取樣及滾雪球的方式選取懷孕14週以上或是生產過後2年內的越南籍及台灣籍婦女各83人。依據知情選擇多面向測量（MMIC）的概念發展出問卷，進行一對一訪談問卷資料收集。研究結果顯示(1)台灣籍婦女的知情選擇情形以及母血篩檢相關知識皆顯著高於越南籍婦女。（2）台灣籍婦女對於母血篩檢的態度與越南籍婦女皆呈現正向的態度。（3）台灣籍婦女的態度篩檢行為一致性為影響台灣籍婦女知情選擇最主要的因素，而影響越南籍婦女知情選擇的最主要因素為對於母血篩檢的相關知識。（4）知識並非預測婦女是否執行母血篩檢或是婦女態度篩檢行為一致性的重要因子。（5）在知識方面，超過50％的婦女並不了解母血篩檢可以自由選擇是否接受。本研究結果將可作為日後在母血篩檢流程上進行知情選擇流程制訂的參考依據。

Data were indicated that approximately 70% to 80% of the Down syndrome babies were delivered by mothers aged below 34 years old. Women in normal childbearing age are recommended to receive the maternal serum screening (MSS) to enhance the prenatal genetic health. Therefore, for those immigrated female spouse, the MSS would be their first genetic test while they were pregnant. Because of the language barrier, health professionals experienced great challenges to achieve of informed choice of MSS in immigrated pregnant women. In order to enhance these immigrated female spouses’ competent to perform informed choice of receiving the MSS, there was a need to understand the women’s informed choice of MSS. Due to the studies regarding the informed choice for women receiving MSS were few, the purpose of the study was to examine the informed choice of MSS in Vietnamese and Taiwanese women. A retrospective study design and the convenient sampling were used to examine the research hypotheses. Eighty-three Vietnamese female spouses and the same number of the Taiwanese women were recruited to participate of the study. The questionnaire based on the concepts of MMIC was developed by the researcher to collect the data. Results of the study show that (1)Taiwanese female spouses’ informed choice and knowledge of MSS were higher than those of Vietnamese women; (2)both of Taiwanese and Vietnamese women displayed positive attitude toward MSS; (3)The major predictors of informed choice of MSS in Taiwanese and Vietnamese female spouses respectively were the consistency of uptake and attitude of MSS and the knowledge of MSS; (4) knowledge of MSS was not the major predictor of the consistency of attitude and uptake the screening; (5) more than 50% of all the research subjects did not understand that MSS was not an obligated prenatal test. Lastly, results of the research could be adopted as the reference to formulate the standards of conducting MSS.

內政部（2007）‧九十六年第四十二週(96年1至9月嬰兒出生狀況統計)
摘自：http://www.moi.gov.tw/stat/index.asp
內政部.（2003）‧外籍與大陸配偶生活狀況調查報告. 台北: 內政部
王明鳳（2004）‧對東南亞外籍新娘婚姻組成及運作方式之探索‧社區發展季刊，105， 197-207。
李瑞全（2003）‧倫理諮詢理論與模式‧應用倫理研究通訊C，25, 24-30。
吳佑珍、唐文慧，（評論人：邱瑜瑾），新移民女性之母職實踐與社會政策制訂，「社會暨健康政策的變動與創新趨勢──邁向多元整合的福利體制」學術研討會，高雄醫學大學， 2005 年 5 月 6 日。
吳佳穎、蔡甫昌、陳慶餘（2003）‧臨床倫理病案討論（1）：病情告知‧當代醫學，30（11），875-878。
施建彬（2003）‧由中國文化脈絡談台灣外籍新娘現象與跨文化通婚適應問題‧研究與動態，8，141-151。
周承珍、李從業、施富金、陳惟華（2002）‧母血篩檢唐氏症結果為陽性的孕婦面對羊膜穿刺術時所感受的護理照護‧新台北護理期刊，4(2)，87-96。
周承珍、李從業、施富金（2001）‧母血篩檢唐氏症陽性孕婦面對羊膜穿刺術的決策過程‧護理研究，9(1)，15-27。
周天給、許怡欣、李丞華、湯澡薰（2006）‧外籍新娘對基層婦產科診所之評價‧台灣家醫誌，16(1)，51-63。
夏曉鵑（2000）‧資本國際化下的國際婚姻—以台灣的「外籍新娘」現象為例‧台灣社會研究季刊，39，45。
孫吉珍、李從業、劉淑娟（1997）‧施行羊膜穿刺術對高齡孕婦的意義‧護理研究，5(2)，171-181。
陳亞甄（2006）‧外籍配偶先生的婚姻觀與婚姻生活‧慈濟大學社會工作研究所碩士論文。
張美鶴、黃美智 （1993）‧婦女接受羊膜穿刺術之認知及態度調查‧護理新象，3(5)，258-265。
張靖梅、余玉眉（2005）‧高齡孕婦獲知需接受羊膜穿刺術至實際行期間之經歷‧醫護科技學刊，7(1)，56-70。
莫黎黎、賴佩玲（2004）‧台灣社會「少子化」與外籍配偶子女的問題初探‧社區發展季刊，105，55-65。
楊秀茹（2004）‧從病患自主權看病患家屬參與醫療決定之權限‧中原大學財經法律學系碩士論文。
楊玉娥 （1995）‧高血清胎兒蛋白孕婦接受羊膜穿次數後之主觀經驗‧慈濟醫學，7，195-202。
黎小娟、李從業 （1998） ‧母血篩檢唐氏症陽性反應的孕婦面對羊膜穿刺之決策經驗‧護理雜誌，45(3)，51-64。
蔣欣欣、喻永生、余玉眉（2005）‧剖析產前遺傳檢測之諮詢與倫理議題‧中華心理衛生學刊，18（1），65-85。
賴鴻政、張盈寬、陳惟華、劉杭生（1998）‧羊膜穿刺術與產前遺傳診斷‧國防醫學，26(2)，102-108。
戴君倚、鍾聿琳（2002）‧影響週產期外籍新娘適應之因素及護理省思‧護理雜誌，49(1)，34-38。
Berg, M. V. D., Timmermans, D. R. M., Kate., L. P. T., Vugt, J. M. G. V., & Wal, G. V. D. (2005). Are pregnant women making informed choices about prenatal screening? Genetics in Medicine, 7(5), 332-338.
Chiang, H.-H., Chao, Y.-M. Y., & Yuh, Y.-S. (2006). Informed choice of pregnant women in prenatal screening tests for Down’s syndrome. Journal of Medical Ethics, 32, 273-277.
Dormandy, E., Tsui E., Y.l., & Marteau, T. M（2006）. Development of a measuree of informed choice suitable for use in low literacy population. Patient Education and Counseling, 66,278-295
Dormandy, E., Michie, S., Hooper, R., & Marteau, T. M（2006）. Informed choice in antenatal Down syndrome screening: A cluster randomized trial of combined versus separate visit testing. Patient Education and Counseling, 61,56-64
Dormandy, E., Michie, S., Hooper, R., & Marteau, T. M. (2005). Low uptake of prenatal screening for Down syndrome in minority ethnic groups and socially deprived groups: a reflection of women’s attitudes or a failure to facilitate informed choices. International Journal of Epidemiology, 34, 346-352.
Fisher, B. M., Varner, M., & Rose, N. C. (2006). Antenatal screening test : Knowledge and practice patterns of obstetricians in utah. American Journal of Medical Genetics Part A 140A, 2464-2468.
Gekas, J., Gondry, J., Mazur, S., Cesbron, P., & Thepot, F. (1999). Informed consent to serum screening for Down syndrome: are women given adequate information. Prenatal Diagnosis, 19(1), 1-7.
Guerny, J. D. (1998). Male involvement in reproductive health: Incorporating gender throughout the life cycle.Technical Support Services System: Occasional Paper Series No. 1. from：http://www.fao.org/docrep/x0257e/x0257e00.htm
Hunt, L. M., Voogd, K. B. d., & Castaneda, H. (2005). The routine and the traumatic in prenatal genetic diagnosis dose clinical information inform patient decision-making? Patient Education and Counseling, 56, 302-312.
Jaques, A. M, Sheffield, L. J., & Halliday, J., L.（2005）. Informed choice in women attending private clinics to undergo first-trimester screening for Down syndrome. Prenatal Diagnosis , 25, 656-664
Khoshnood, B., Blondel, B., Vigan, C. D., & Breart, G. (2004). Socioeconomic barriers to informed decisionmaking regarding maternal serum screening for Down syndrome: results of the French national perinatal survey of 1998. American Journal of Public Health, 94(3), 484-491.
Liamputtong, P., & Watson, L., (2002). The voices and concerns about prenatal testing of cambodian, Lao and Vietnamese women in Australia. Midwifery, 18, 304-313.
Nagle, C., McCarthy, P., & Wallace, E. (2000). Uptake of Down syndrome screening in an Australian Vietnamese population. Australian and New Zealand Journal of Obstetrics and Gynaecology, 40(2), 157-159.
Michie, S. Smith, D., & Marteau, T, M. (1999). Prenatal tests: how are women deciding? Prenatal Diagnosis,19(8), 743-748
Marteau, T. M., Dormandy, E., & Michie, S. (2001). A measure of infromed choice. Health Expectations, 4, 99-108.
Michie, S., Dormandy, E., & Marteau, T. M. (2002). The multi-dimensional measure of informed choice: a validation study. Patient Education and Counseling, 48, 87-91.
Michie, S., Dormandy, E., & Marteau, T. M. (2003). Informed choice: understanding knowledge in the context of screening uptake. Patient Education and Counseling, 50, 247-253.
Mullany, B. C., Hindin, M. J., & Bcker, S. (2005). Can women's autonomy impede male involvement in pregnancy health in Katmandu, Nepal? Social Science & Medicine, 61, 1993-2006.
Rower, H. J., Fisher, J. R. W., & Quninlivan, J. A. (2006). Are pregnant Australian women well informed about prenatal genetic screening? A systematic investigation using the Multidimensional Measure of Informed Choice. Australian and New Zealand Journal of Obstetrics and Gynaecology, 46, 433-439.
Suurmond, J., & Seeleman, C. (2006). Share decision-making in an intercultural context barriers in the interaction between physicians and immigrant patients. Patient Education and Counseling 60, 253-259.
Tercyak, K. P., Johnson, S. B., Roberts, S. F., & Cruz, A. C. ( 2001 ). Psychological response to prenatal genetic counseling and amniocentesis. Patient Education and Counseling, 43, 73-84
Tsianakas, V., & lamputtong, P. (2002). Prenatal testing: the perceptions and experiences of Muslim women in Australia. Journal of reproductive and infant psychology, 20(1), 7-24.
Vergani, P., Locatelli, A., Biffi, A., Giriello, E., Zagarella, A., Pezzullo, J. C., & Ghidini, A. ( 2002 ). Factors affecting the decision regarding amniocentesis in women at genetic risk because of age 35 years or older. Prenatal Diagnosis, 22, 769-774
Weinans, M. J. N., Huijsson, A. M. G., Tymstra, T., Gerrits, M. C. F., Beekhuis, J. R., & Mantingh, A. (2000). How women deal with the results of serum screening for Down syndrome in the second trimester of pregnancy. Prenatal Diagnosis, 20, 705-708
Weinans, J. N.（2005）. Partnership: Doctor and patient. Spine, 30(3), 269-271
Yang, Y.-m., & Wang, h.-h. (2003). Life and health concerns of indonesian women in transnational marriages in Taiwan. Journal of Nursing Research, 11(3), 167-176.