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研究生: 蔡昊曄
Tsai, Hao-Yeh
論文名稱: 探討纖維母細胞生長因子21纖維母細胞生長因子受體1和β-klotho三聚體復合物於體內和體外實驗的變化
Investigation of FGF21-FGFR1-β-klotho ternary complex in vivo and in vitro
指導教授: 陳珮君
Chen, Pei-Chung
學位類別: 碩士
Master
系所名稱: 醫學院 - 生理學研究所
Department of Physiology
論文出版年: 2024
畢業學年度: 112
語文別: 英文
論文頁數: 44
中文關鍵詞: 肥胖憂鬱症中腦邊緣系統路徑格列苯脲纖維母細胞生長因子21纖維母細胞生長因子受體1和β-klotho三聚體複合物
外文關鍵詞: Obesity, depression, mesolimbic pathway, glibencalmide(GB), FGF21-FGFR1-β-klotho ternary complex
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  • 中文摘要 I Abstract III Figure Contents VI Introduction 1 Obesity and depression 1 Dopamine reward system 2 Glibenclamide 2 FGF21 and receptors 3 Endocytosis and recycling 4 Lysosomal repositioning 4 Research rationales and hypothesis 6 Specific aims 6 Materials and methods 7 Animals 7 High-fat diet (HFD) induced depression mice model 7 Drug and antibody 7 Miniosmotic pump implantation 8 Golgi staining 8 Immunocytochemistry (ICC) 8 Immunofluorescent (IF) 9 Western blot 9 mRNA expression analysis 10 Co-immunoprecipitation 10 Image analysis 10 Statistical analysis 11 Results 12 Discussion 16 Figures 19 Reference 34

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