近幾年來以量子點（QDs）做為光學感測材料已廣泛被應用於生物醫學領域中，量子點的光學特性具有寬廣的激發波長、狹窄的放射光與耐光漂白等有優點，另外在單一光源激發下，量子點會隨粒徑大小而有不同的放射光，因此可以同時滿足高靈敏檢測和長時間動態監測的需要。利用量子點界面與環境待測物之間的電子轉移轉變為螢光訊號來檢測待測之濃度，目前普遍用於生理與環境分析應用也漸漸受到重視。
本研究發展一種高性能光纖式銅離子感測器，此技術是利用熱裂解的方法合成出量子點（CdSe/ZnS），以及利用微乳化 （microemusion）方法將奈米粒子包覆於在silica particles中形成 核-殼奈米粒子(core-shell nanoparticles)，最後將核-殼奈米粒子加入sol-gel matrix中再將之塗佈在光纖端面。由光強度的變化我們可以定量出溶液中的銅離子濃度。本研究所開發的光纖銅離子感測器之偵測範圍可由0~10 μM，而其偵測極限可達0.9 μM。此銅離子感測器具有高靈敏度、離子辨識度與化學相容性。
另外一方面作者發展出核-殼結構奈米粒子(core-shell nanoparticles)用於氨氣感測，利用為乳化方式將二氧化矽(SiO2)包覆於量子點(CdSe)，達到單一分布核-殼結構奈米粒子，最後將核-殼結構奈米粒子加入sol-gel matrix中再將之塗佈在光纖端面。藉由螢光效率做為氨氣分子濃度檢測系統之基礎。本研究所開發的光纖氨氣感測器之靈敏度(IN2/IO2)可達42.4，在氨氣環境下(400 ppm)感測器之反應時間分別為 6.1秒(放射螢光強度由氮氣變化到氨氣之所需時間)與942.2秒(放射螢光強度由氨氣變化到氮氣之所需時間)。核殼結構奈米粒子有親水性、良好的環境相容性與光學特性。此研究可提高光纖感測系統將能提高訊噪比，而將更有效的量測及分析訊號。並且此結合將使多孔性 (mesoporous)材料能夠具有更高靈敏度及穩定性。
除此之外，作者也提出了光纖氧氣與溫度雙感測器，其技術同樣利用熱裂解的方法合成出量子點（CdSe），並利用微乳化方法將氧氣感測材料（PtTFPP）與溫度感測材料（CdSe）同時包覆於在silica particles中形成core-shell nanoparticles，最後將core-shell nanoparticles加入sol-gel matrix中再將之塗佈在光纖端面，利用一個 LED (409nm)作為激發光源去同時激發溫度與氧氣感測材料而產生不同波段的放射螢光，在頻譜中可以同時分析量子點波長移動（Shift）所代表的溫度變化與氧氣感測材料螢光強度衰減（Quenching）所代表的氧氣濃度變化，並且在頻譜中不會有串音的現象發生，進而去同時分析當時之溫度與氧氣濃度。本研究所開發的光纖氧氣感測器之靈敏度(IN2/IO2)可達18，感測器之反應時間分別為 0.37秒(放射螢光強度由100%氮氣變化到100%氧氣之所需時間)與4.7秒(放射螢光強度由100%氧氣變化到100%氮氣之所需時間)。

In recent years, quantum dots (QDs) have emerged as one of the promising fluorescent sensor owing to their relatively high quantum yields, broad absorption spectra, unique narrow emission, and good photostability. The optical property of QDs is strongly dependent on the property of the surface states, as well as chemical and physical environment. The surface interaction between analytes and QDs will influence the efficiency of the electron–hole recombination process as the presence of the target molecular can be transduction into detectable fluorescence signals.
A novel, high-performance optical fiber sensor for Cu2+ ion is proposed based on silica-coated CdSe/ZnS nanoparticles immobilized on the tip of an optical fiber by a sol–gel matrix. The Stern-Volmer equation showed a good linear response in the range 0-10 μM with the correlation coefficient of R2=0.9858. The resolution of this sensor detected by a commercial hand-held spectrometer was about 0.9 μM and therefore it is an ideal solution for applications in chemical and medical detections. The use of a silica-coated CdSe/ZnS QD has a number of key advantages as compared to the organic ligand modified QDs, including better selectivity, higher sensitivity, better chemical stability, and more stable with wide pH value.
On the other hand, the author developed a high-performance ammonia vapor sensor is proposed comprising CdSe/SiO2 core-shell nanoparticles embedded in a sol-gel matrix immobilized on the tip of an optical fiber. The experimental results have shown that the sensor exhibits a linear response for ammonia vapor concentrations in the range of 0 ~ 400 ppm. Furthermore, it has been shown that the sensor has a response (I0/I) of approximately 42.4 when exposed to ammonia vapor with a concentration of 400 ppm under room temperature conditions. Finally, it has been shown that the sensor has a response time of 6.1 s when switching from pure N2 to a mixed N2 – ammonia vapor with an ammonia concentration of 400 ppm and 942.2 s when switching in the reverse direction. Overall, the results show that the proposed sensor has many key advantages compared to optical sensors based on organic sensitive dye, including a higher response (I0/I), an improved chemical stability, and full reversibility.
Furthermore, the author developed a simple, low-cost optical-fiber sensor has been proposed for the dual sensing of temperature and oxygen concentrations. The sensor comprises PtTFPP-doped CdSe/SiO2 nanoparticles immobilized in a TFP-TriMOS) composite xerogel. The PtTFPP dye provides an oxygen sensing function, while the CdSe/ SiO2 nanoparticles provide a temperature sensing function. Both indicators are excited using a single wavelength of 409 nm. It has been shown that the response (I0/I) of the dual sensor is approximately 18 under room temperature conditions. The response time was 0.37 s when switching from nitrogen to oxygen, and 4.7 s when switching in the reverse direction. In conclusion, the dual sensor developed in this study provides a simple and accurate solution for the simultaneous non-contact sensing of temperature and oxygen, and is therefore expected to find use in a variety of environmental and medical sensing applications.

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