Treatment of open wounds in diabetic patients have always been a topic of concern. Because of long healing time, this type of wound is more susceptible to inflammation, sores or infections than normal wounds in patient without diabetes and has caused many serious effects on the health and life of these diabetic patients. Here, we focus on the fabrication of NaCeF4:Tb3+ nanoparticles with unique properties to support wound healing process.
Roussin’s Black Salts (RBS – NO donor) modified on the nanoparticles has the ability to release NO gas under UV irradiation as trigger. Notably, NO gas is known to have a positive effect in wound healing. Moreover, through the same stimulating light source, this kind of material is capable of emitting light at longer wavelength (like 550 nm green light). The surface of nanoparticles is being coated with 4–Aminosalicylic acid (4–ASA) and furthermore Fe(II) is added to form 4–ASA–Fe(II). In an environment with reactive oxygen species (ROS) such as •OH, ASA–Fe(II) is easily oxidized to ASA–Fe(III). This ASA–Fe(III) has strong absorption nearby 550 nm so it can quench the green light emitted from NaCeF4:Tb3+ nanoparticles. Thus, based on the amount of green light that is absorbed, •OH content can be detected in the wound site. This is very important in the wound healing treatment process as well as evaluating the effectiveness of NO gas transmission for treatment.
So in this study, we try to synthesis NaCeF4:Tb3+ nanoparticles with two main purposes:
Firstly, to deliver NO gas upon light triggering
Secondly, to use to quantity •OH content in the physiological

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