厭惡或欲求的情緒記憶形成對行為有重要的影響。目前已知，杏仁核可以調節不同情緒學習的形成，而促使其他腦區記憶的形成，包括海馬迴與前額葉皮質。在我們實驗室先前的發現指出，提取古柯鹼場地制約偏好或被動逃避反應後，立即在杏仁核側底核區內注射局部麻醉劑利多卡因，會在後續的測試中消除相關的記憶。也就是說，干擾提取記憶的再穩固化可以削弱其他未提取的記憶。對於這個結果有一種可能的解釋是在提取古柯鹼場地制約偏好和被動逃避反應時杏仁核側底核區有相同的神經元作反應。針對這個問題，首先，訓練老鼠學習古柯鹼場地制約偏好和被動逃避學習。接著，提取這些老鼠的其中一個或兩個記憶並計算前額葉(扣帶迴、前邊緣皮質、內邊緣皮質)，杏仁核(側底核區、中央核區)和海馬迴(CA1區、CA3區、齒狀回)的c-Fos表現情形。公鼠(C57BL/6Nj mice)分成四組。第一組只提取古柯鹼場地制約偏好，第二組只提取被動逃避反應，第三組提取古柯鹼場地制約偏好和被動逃避反應，第四組沒有提取任何記憶。結果顯示四組中，在前額葉(扣帶迴、前邊緣皮質、內邊緣皮質)，杏仁核中央核區和海馬迴(CA1區、CA3區、齒狀回)的Fos表現是類似的。相對的，在提取的程序之後，同時提取古柯鹼場地制約偏好與被動逃避反應記憶的這一組在杏仁核側底核區Fos表現是四組中最多的。綜合這些結果暗示提取古柯鹼場地制約偏好與被動逃避反應在杏仁核側底核區包含了不同群的神經元。

Emotional memories in the aversive or appetitive forms are important for guiding behavior. Amygdala has been well known to directly mediate various forms of emotional learning and facilitate memory formation in other regions, including the hippocampus and prefrontal cortex. Our previous finding has shown that intra-BLA infusion with lidocaine, a local anesthetic, immediately after the reactivation of either cocaine (coc)-induced conditioned place preference (CPP) or passive avoidance (PA) diminishes the corresponding memory in subsequent retests. That is, disruption of the reconsolidation of a reactivated memory can impair the reconsolidation of other non-reactivated memory. One possibility for explaining this observation is that same neurons in basolateral amygdala (BLA) are responsible for reactivation of coc-induced CPP and PA memory. To address this question, we first trained mice to learn coc-induced CPP and PA. We, then, reactivated either one or both memory in these mice and examine Fos expression in the prefrontal cortex (Cg1, PrL and IL), amygdale (BLA and CeA) and hippocampus (CA1, CA3 and DG). Male C57BL/6Nj mice were divided into four groups. The first group received reactivation of coc-induced CPP only. The second group underwent reactivation of PA memory only. The third group experienced reactivation of both CPP and PA memories. The remaining group did not receive any memory reactivation. The data showed that Fos expression in the prefrontal cortex (Cg1, PrL and IL), central nuclei of amygdale (CeA) and hippocampus (CA1, CA3 and DG) were comparable in these four groups. In contrast, BLA Fos expression immediately after reactivation of procedure, both coc- induced CPP and PA memory was the greatest in number among the four groups. These results, taken together, suggest that different groups of BLA neurons are involved in the reactivation of coc-induced CPP and PA.

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