雖然鈦及其合金的醫療器材在生醫領域已被廣泛使用，但在人體使用中仍然有血液相容性不佳的問題存在。為了克服這項問題，研究中我們嘗試新的表面改質方法去改善鈦表面的血液相容性。
此研究中，將親水和疏水性單體透過傳統自由基聚合成功製備出一系列無規共聚物，其中親水性單體選擇乙基磷酸(vinyphosphonic acid,VPA)，不只是因為它本身極為親水，還因為結構中含有亞磷酸官能基，再加熱之後可提供穩固的共價鍵結於鈦基材表面。而疏水性單體選擇2,2,2-三氟甲基丙烯酸酯(2,2,2-trifluoroethyl methacrylate, TFEMA)，因為它有許多獨特的特性，例如：表面張力低、不沾性及化學和熱的穩定性。
將製備好的共聚物藉由滴塗層法(drop-coating)塗佈於鈦表面並加熱，使其進行鍵結反應。合成之共聚物藉由核磁共振光譜儀(nuclear magnetic resonance spectroscopy, NMR)做組成分析及基本性質鑑定。改質完鈦金屬表面的親疏水性及表面元素組成的分析則利用表面接觸角(contact angle, CA)和電子能譜儀(X-ray photoelectron spectroscopy, XPS)。此外，表面的血液相容性是用體外血小板貼附實驗來探討。
綜合各實驗結果，最佳血液相容性表面是由兩種單體VPA及TFEMA莫耳進料比為7:3聚合物改質而成的，展現出低的接觸角、數量少和未活化的血小板貼附。在此研究中，藉由簡單的滴塗層法和加熱成功在鈦金屬表面上製備出穩定的共價鍵結，具備改善現今市售鈦金屬生醫材料的淺力。

Although widely being used in biomedical fields, the titanium-based materials still face many challenges in hemocompatibility. To overcome this problem, a new surface modification method for improving hemocompatibility of titanium was attempted. In this work, a series of random copolymers with hydrophobic and hydrophilic monomers have been synthesized by traditional free radical copolymerization. The hydrophilic monomer, vinyphosphonic acid (VPA), was selected because it is not only very hydrophilic but also carrying the phosphonic acid groups that can impart covalent binding to the titanium surfaces after heating. The hydrophobic monomer, 2, 2, 2-trifluoroethyl methacrylate (TFEMA), was chosen because it contains several unique properties, such as low surface tension as well as the chemical and thermal stability. These polymers’ coatings were formed on titanium surfaces using drop-coating method followed by heating for the formation of a covalent-bound surface layer. These copolymers were analyzed with NMR, FTIR and EDS. The surface characteristics of these coating layers were examined by contact angle, SEM and XPS. Furthermore, the hemocompatibility of surface was characterized through in vitro platelets adhesion testing. The optimized coating surface was the polymer formed with the monomer feeding ratio of VPA: TFEMA=7:3, which showed low contact angle, less and non-activated platelets adhesion. This work successfully fabricated a stable surface on titanium by simply drop-coating and heating, and the surface was of potential for improving the platelet compatibility of titanium-based biomaterials.

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