本研究目的在於瞭解芳香蠟燭在不同組成及燃燒環境操作條件下，產生之奈米微粒粒徑分佈特徵，及推估工作人員呼吸道頭區 (H)、氣管支氣管區 (TB)、及肺泡區 (A) 奈米微粒之個數與表面積濃度暴露情形，並瞭解其排放率與排放係數，最後進行芳療業者奈米微粒之呼吸道終生每日平均暴露劑量（Life-time Average Daily Dose, LADD）。本研究使用一暴露腔進行芳香蠟燭燃燒測試，測試前並對其測試環境之穩定性及均勻性加以確認。測試之芳香蠟燭成分組合包括三種薰衣草精油添加比例 (0 %、3 %及9 %)，測試之環境為在固定相對濕度(RH=70 %)下之三種空氣換氣率 (1.5 ACH、3.0 ACH及5.0 ACH)，採樣方法以Modified Electrical Aerosol Detector進行奈米微粒之粒徑分布量測。研究結果顯示：(1) 全部測試之芳香蠟燭在不同ACH下所產生之奈米微粒CMD均為10.7 nm，而相同成份之蠟燭其σg隨著ACH上升會有下降之趨勢; (2) 各種芳香蠟燭在不同ACH下，隨著ACH增加其個數濃度均有增加的趨勢。此外，總表面積濃度與總個數濃度亦有相同的趨勢; (3) 不同精油添加比例芳香蠟燭在相同ACH燃燒時，其個數濃度會隨精油添加比例增加而下降。此外，其總表面積濃度之結果和總個數濃度亦有一致性的趨勢; (4) 芳香蠟燭燃燒生成之奈米微粒沉降在不同呼吸道區域之個數濃度，在不同精油添加比例之芳香蠟燭在不同空氣置換率下，皆呈A區>TB區>H區之趨勢。從表面積濃度結果來看，亦呈相同趨勢; (5)在不同ACH下，吸入奈米微粒之LADD會隨著ACH增加而增加; (6)芳療業者之奈米微粒LADD較其他職場之奈米微粒暴露來得高，顯示其暴露風險有其考量之必要性。本研究建議未來進一步之研究芳香蠟燭逸散之奈米微粒毒理特性; 另有鑑於增加ACH會導致LADD之上升，故減少暴露時間與蠟燭使用量為減少暴露之有效策略。

The aim of this study was to characterize the emission of nanoparticles, assess concentrations of both number and surface area of nanoparticles deposited in different respiratory tract regions during the burning of fragranced candle, and to assess the life-time average daily dose (LADD) of a aromatherapy worker. The whole study was conducted in an exposure chamber with confirmed stability and uniformity. The exposure chamber was specified at fixed relative humidity of 70 % but with three air exchange rates of 1.5, 3.0 and 5.0 ACH. Three tested fragranced candles were tested containing 0 %、3 % and 9 % lavender essence, respectively. All air samples were measured by a modified electrical aerosol detector. Results show that (1) combustion of all fragranced candles will result in the generation of nanoparticles with a constant CMD of 10.7 nm, but σg decreased as ACH increased; (2) the emitted nanoparticle number concentrations increased as ACH increased, and the same trend was found in the corresponding surface area concentrations; (3) the emitted nanoparticle number concentrations decreased as the fraction of added essence increased, and the same trend was found in the corresponding surface area concentrations; (4) all emitted number and surface area concentration deposited in the respiratory tract shared the same trend as: alveolar region > trachelobronchial region > head region; (5) LADD increased as ACH increased; and (6) the aromatherapy worker was found with higher LADD than those of other occupations. It is suggested that more toxicological studies are needed to investigate nanoparticles emitted from the combustion of fragranced candles. Since the increase of the ACH will lead to the increase in LADD, reducing exposure time and the amount of candle used will be a better control strategy for reducing exposures.

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