本實驗室藉著血行動力學以及脈診理論開發出血行動力儀，以高敏感度的電容式麥克風收取手腕橈動脈處之脈搏聲波訊號。此訊號中包含著心血管系統與其他生理狀況意涵，本次實驗是將收錄之聲音訊號藉由頻譜估計方法找尋其變化特徵趨勢。由共振理論可得知心臟相關之訊號經由時頻轉換後位於0.8~2Hz之間。將患有心臟瓣膜疾病與健康之受測者之五分鐘聲波數據濾波後，由Yule-Walker方法建立其AR迴歸模型。再將其病患各瓣膜病變程度與其頻譜特徵出現與否作相關性比較。結果在二尖瓣閉鎖不全與三尖瓣閉鎖不全上，其頻譜特徵有著較高的相關性。再藉由AR迴歸模型之特徵位置與疾病相關性，判斷其音頻位置特徵與左心室或右心室射血不足相關。血行動力儀具備了方便與易於判讀之特性，可以用來協助臨床基層醫療人員對於心臟瓣膜疾病初步的簡易評估，甚至是一般民眾在日常生活中的自我檢測。

Non-Invasive Hemodynamic Analyzer (NIHD) use condenser microphone for mearsuring the rudimentary data at the wrist radial artery. The acoustic signal contains some information of the cardiovascular system and other physiological conditions. The purpose of this research is dismantling the signal which collected from heart valve diseases patients, and find the feature from their data. I model it by Yule-Walker method, then try to find the relationship between spectral characteristic and different kinds of valve diseases. At last, results of statistics shows that when patients’ heart valve insufficiency is more severer, the characteristics of waveform is more easier to be analyzed. Non-Invasive Hemodynamic Analyzer operate simply and make interpretation easily. It can be used to assist in clinical primary care staff for valvular heart disease simple preliminary assessment, even ordinary people in everyday life self-test.

[1] Mueller, C., Scholer, A., Laule-Kilian, K., Martina, B., Schindler, C., Buser, P., Pfisterer, M., and Perruchoud, A. P., “Use of B-Type Natriuretic Peptide in the Evaluation and Management of Acute Dyspnea”, The New England Journal of Medicine, Vol.350, pp.647-654, 2004.
[2] Tervonen, V., Arjamaa, O., Kokkonen, K., Ruskoaho, H., and Vuolteenaho, O., “A novel cardiac hormone related to A-, B- and C-type natriuretic peptides”, Endocrinology, Vol.139, No.9, pp.4021-4025, 1998.
[3] Ellis, H., Clinical anatomy: a revision and applied anatomy for clinical students (11th ed.), Malden, Mass.: Blackwell Pub., pp.29-36, 2006.
[4] Marieb, E. N., Wilhelm, P. B., and Mallatt, J., Human anatomy (6th ed.), Upper Saddle River, N.J., Harlow: Pearson Education, pp.556-568, 2011.
[5] 沈清良，實用解剖學，臺北市 : 華杏出版股份有限公司，pp.156-158，2011。
[6] Milnor, W. R., Hemodynamics: The historical development of hemodynamics (2nd ed.), Baltimore:Williams & Wilkins, pp.3-10, 1989.
[7] Sutera, S. P., and Skalak, R., “The history of Poiseuille's law”, Annual Review of Fluid Mechanics, Vol.25, pp.1-19, 1993.
[8] Sagawa, K., Lie, R. K., and Schaefer, J., “Translation of Otto frank's paper “Die Grundform des arteriellen Pulses” zeitschrift für biologie 37: 483–526 (1899)”, Journal of Molecular and Cellular Cardiology, Vol.22, Issue 3, pp.253-254, 1990.
[9] Tijsseling, A. S., and Anderson, A., “A. Isebree Moens and D.J. Korteweg: on the speed of propagation of waves in elastic tubes”, Centre for Analysis, Scientific computing and Applications Report, pp.12-42, 2012.
[10] Gosling, R. G., and Budge, M. M., “Terminology for Describing the Elastic Behavior of Arteries”, American Heart Association, Hypertension, Vol.41, No.6, pp.1180-1182, 2003.
[11] Moayeri, M. S., and Zendehbudi, G. R., “Effects of elastic property ofthe wall on flow characteristics through arterial stenosis”, Journal of Biomechanics, Vol.36, Issue4, pp. 525-535, 2003.
[12] Bergel, D. H., and Schultz, D. L., “Arterial elasticity and fluid dynamics”, Progress in biophysics and molecular biology, Vol.22, pp.1-36, 1971.
[13] Copeland, J. G., Arabia, F. A., Tsau, P. H., Nolan, P. E., McClellan, D., Smith, R. G., and Slepian, M. J., “Total artificial hearts :bridge to transplantation”, Cardiology clinics, Vol.21, No.1, pp.101-113, 2003.
[14] Wang, Y. Y., Chang, S. L., Wu, Y. E., Hsu, T. L., and Wang, W. K., “Resonance.-The missing phenomenon in hemodynamics”, Circulation Research, Vol.69, pp.246-249, 1991.
[15] 張修誠、王唯工、黃維三、徐則林, “針刺足三里穴對脈波頻譜之影響”, 中醫藥雜誌，第四卷第一期，pp.15-38，1993。
[16] 王唯工，氣的樂章，臺北市 : 大塊文化出版股份有限公司，pp.75-124，2002。
[17] 王唯工， “臟器對血流波之影響” ，行政院國家科學委員會專題研究計畫成果報告，1993。
[18] Yu, G. L., Wang, Y. L., and Wang, W. K., “Resonance in the kidney system of rats”, American Journal of Physiology, Heart and Circulatory Physiology, Vol.267, No.4, pp.1544-1548, 1994.
[19] Young, S. T., Wang, W. K., Chang, L. S., and Kuo, T. S., “The filter properties of the arterial beds of organs in rats”, Acta Physiologica Scandinavica, Vol.145, pp.401-406, 1992.
[20] 林佳鈺，「脈搏波中有關心血管之訊號分析」，國立成功大學航空太空工程學系碩士論文，pp.7-22，2009。
[21] Jian-Xing Wu, Chian-Ming Li, Wei-Ling Chen, Chia-Hung Lin, Tainsong Chen, “Application of Van der Pol oscillator screening for peripheral arterial disease in patients with diabetes mellitus”, Journal of Biomedical Science and Engineering, vol. 6, pp.1143-1154, 2013.
[22] Wei-Ling Chen, Chung-Dann Kan, Chia-Hung Lin, Chen, T., “A Rule-based Decision-making Diagnosis System to Evaluate arteriovenous Shunt Stenosis for Hemodialysis Treatment of Patients Using Fuzzy Petri Nets, ” IEEE Journal of Biomedical and Health Informatics, vol. 18, no. 2, pp. 703-713, 2014.
[23] Wei-Ling Chen, Chia-Hung Lin, Tainsong Chen , Pei-Jarn Chen, and Chung-Dann Kan, “Stenosis Detection using Burg Method with Autoregressive Model for Hemodialysis Patients,” Journal of Medical and Biomedical Engineering, vol. 33, no. 4, pp. 356-362, 2013.
[24] Wei-Ling Chen, Chia-Hung Lin, Tainsong Chen, Chung-Dann Kan, “The feasibility of Application Phonoangiography with Fractional Order Chaotic System in Arteriovenous Shunt Stenosis Detection”, IEEE The International Conference on Orange Technologies, pp. 123-126, 2013.
[25] 李尚胤，「脈聲儀定性校正與時頻轉換之應用」，國立成功大學航空太空工程學系碩士論文，pp.13-14，2008。
[26] Advansed Acoustic Technology Corp 麥克風常見問題，網址：
http://www.buzzer-speaker.com/manufacturer/tw/faq/microphone%20advantage.htm
[27] 白明憲，工程聲學，臺北市 : 全華科技圖書股份有限公司，pp.1-1~1-12，2006。
[28] Salivahanan, S., Vallavaraj, A., and Gnanapriya, C.(原著)，林忠逸(審閱)，數位訊號處理，臺北市 : 美商麥格羅．希爾國際股份有限公司 台灣分公司，pp.432-445，2002。
[29] 林宸生、邱創乾、陳德請，數位訊號處理，台北市：高立圖書有限公司，pp.153-155，1999。
[30] S.V. Vaseghi, “Advanced Signal Processing and Digital Noise Reduction”,Wiley Teubner N.M.,1996