中風是世界上前三大造成死亡和殘障的疾病 。而腦 電刺激是 近期十 分引人 關 注 的 中風治療，其效益的評估自然也十分重要。 瞳孔光反 射是很 常見的中 風診斷 、 功 能 回覆評估方式之一。透過測量瞳孔光反射功 能，我們 可以判 斷腦電刺 激對於 中 風 復 原的效果。
本研究中，使用了新開發的瞳孔測量儀測量 大鼠的 瞳孔光反 射。此 新式瞳 孔 測 量 儀運用光纖將紅外線雷射光導入植入大鼠頭 部的近紅 外線光 譜儀(N IRS ) 導 管 中，作為瞳孔測量儀的光源。我們將大鼠分 為實驗組 及對照 組。兩組 大鼠皆 接 受 導 管植入手術，以利使用新式的瞳孔測量儀觀 測瞳孔光 反射。 實驗組的 大鼠並 接 受 M CAO (middle cerebral artery occlusion)手術引起缺血性中風。透過比較兩組 大鼠的數據差異，做為判定此瞳孔測量儀是 否具備評 估中風 後復健手 段之效 果 的 能 力。
透過數據分析，我們可以發現，中風大鼠需 要較長 的時間進 行瞳孔 反應， 並 且 其 收縮比例不若正常大鼠。因此，我們能以此為依據，認定此新式瞳孔測量儀具 有評 估腦電刺激等中風復建手段的能力。
關鍵詞:瞳孔測量儀、中風、腦電刺激

According to WHO, stroke is the top three cause of mortality and the main cause of disability around the world. Among varied treatment modalities, brain stimulation has shown great potential for facilitate brain plasticity. Pupillary light reflex has been commonly used by medical professional for brain response assessment. The aim of this study is to develop a new adaptation of pupillometry and utilize light reflex as an assessment tool for brain stimulation on rats with stroke.
In this study, a new adaptation of pupillometry using near-infrared spectroscopy (NIRS) cannula as a guidance for infrared lighting is developed. This newly developed device utilizes a laser emitter as light source. The light goes through the NIRS cannulas via an optical fiber to light up the pupil, as opposed to traditional pupillometry with external IR lighting setup from the camera or ambient light.
Rats are divided into 2 groups in our experiment: the control group and experimental group. All rats were implanted with NIRS cannulas to observe pupillary light reflex with the new adaptation of pupillometry. The experimental group received MCAO (middle cerebral artery occlusion) surgery for stroke induction. The result of shows that rat with stroke needs longer response time and the response is weaker than normal rats. Preliminary animal study indicates that proper design of pupillometry could serve as an assessment tool for evaluating the progress of treatment, such as brain stimulation, on subjects with stroke.
Keywords: pupillometry, stroke, brain stimulation, near infrared light

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