隨著工業和技術的發展，有越來越多種化學物質被廣泛地添加於個人保健用品之中，這些物質為人們帶來便利的同時，也透過各種管道進入環境。有機紫外線過濾劑常被添加至防曬乳及乳液等化妝品內，而這些紫外線過濾劑是水體中的新興污染物之一，當我們在海邊活動時其會流入至環境中，使得水生環境受到危害。
本研究採集臺灣北部及南部地區之觀光海灘之海水樣本以及沙子樣本，使用報導基因重組酵母菌試驗法檢測紫外線過濾劑及各樣本之內分泌干擾活性，亦利用液相層析串聯式質譜儀分析目標物質之環境濃度。內分泌干擾活性試驗結果顯示紫外線過濾劑中大多具有抗雄激素活性、抗糖皮質激素活性、抗鹽皮質激素活性、抗孕激素活性以及類芳香烴活性。抗雄激素活性、抗雌激素活性、抗鹽皮質激素活性以及類芳香烴活性可於海水樣本中測得；類芳香烴活性也可於沙子樣本中測得。
液相層析串聯式質譜儀分析結果顯示海水中檢測到最高濃度之物質為 2-羥基-4甲氧基二苯甲酮 (2-Hydroxy-4-methoxybenzophenone, BP3) (597.4 ng/L)，於懸浮固相樣本中檢測到最高濃度物質為奧克立林 (Octocrylene, OC) (71.6 ng/L)，於沙子樣本中檢測到最高濃度之物質為水楊酸辛酯 (2-Ethylhexyl salicylate, ES) (27.0 ng/g sand dw)。
以風險商數評估各海水樣本中紫外線過濾劑的生態風險後，確認大部分的目標紫外線過濾劑不具生態風險，僅有於夏季福隆海水浴場 (FL-S) 測得之BP3具有高度風險 (風險商數大於 1.0)，於夏季金沙灣海濱公園 (JS-S)及夏季漁光島沙灘 (YI-S)測得之2,4-二羥基二苯甲酮 (2,4-Dihydroxybenzophenone, BP1)、於 JS-S 測得之 BP3、及於FL-S測得之胡莫柳酯 (Homosalate, HS)、OC具有中度風險 (0.1<風險商數<1.0)。此外，經計算生物試驗與儀器分析結果之相關性，發現 BP3 於部分樣本之類芳香烴活性之貢獻度大於 10%，而其餘目標紫外線過濾劑並非樣本中內分泌干擾活性之主要貢獻來源。

With the development of industry and technology, an increasing number of chemicals are being widely added to personal care products. While these substances bring convenience to people, they also enter the environment through various channels. Organic UV filters are commonly added to sunscreens and lotions, making them one of the emerging contaminants in aquatic environments. When we engage in activities at the beach, these UV filters can enter the environment, posing a threat to aquatic ecosystems.
This study focused on tourist beaches in northern and southern Taiwan. Seawater and sand samples were collected from various sampling sites. The endocrine-disrupting activities of UV filters and the samples were detected using recombinant yeast assays, and the environmental concentrations of target substances were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results of the endocrine disrupting activity tests showed that most UV filters exhibited anti-androgenic, anti-glucocorticoid, anti-mineralocorticoid, anti-progestogenic, and aryl hydrocarbon receptor (AhR) agonist activities. Anti-androgenic, anti-estrogenic, anti-mineralocorticoid, and AhR agonist activities were detected in seawater samples. Sand samples exhibited AhR agonist activities as well.
LC-MS/MS analysis results indicated that 2-hydroxy-4-methoxybenzophenone (BP3), octocrylene (OC), and 2-ethylhexyl salicylate (ES) were detected in seawater, suspended solids, and sand samples at the highest concentrations (597.4 ng/L, 71.6 ng/L, 27.0 ng/g sand dw), respectively.
Ecological risk assessment of UV filters in seawater samples showed that most target UV filters posed no ecological risks, only BP3 at Fulong beach in summer (FL-S) showed a high risk (risk quotient > 1.0), 2,4-dihydroxybenzophenone (BP1) at Jinsha Bay beach park in summer (JS-S) and Yuguang Island beach in summer (YI-S), BP3 at JS-S and homosalate (HS), and OC at FL-S posed moderate risks (0.1 < risk quotient < 1.0). The correlation between bioassay results and instrumental analysis results were calculated as well. Except for BP3, which contributed to more than 10% of the AhR agonist activities in some samples, the other target UV filters were not the primary contributors to the endocrine-disrupting activities of the samples.

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