成功大學博碩士論文系統

簡易檢索 / 詳目顯示

回結果列表

研究生：	林俊宏 Lin, Chun-Hung
論文名稱：	發光二極體光療系統於新生兒黃疸治療研究 Treatment of Neonatal Jaundice - LED Phototherapy System Research
指導教授：	周榮華 Chou, Jung-Hua
學位類別：	碩士 Master
系所名稱：	工學院 - 工程科學系碩士在職專班 Department of Engineering Science (on the job class)
論文出版年：	2012
畢業學年度：	100
語文別：	中文
論文頁數：	71
中文關鍵詞：	新生兒黃疸、發光二極體光療、膽紅素
外文關鍵詞：	neonatal jaundice, LED phototherapy, bilirubin
相關次數：	點閱：129 下載：4
分享至:	分享至facebook 分享至twitter

查詢本校圖書館目錄查詢臺灣博碩士論文知識加值系統勘誤回報

從遠古時期火把至今的發光二極體人們因照明的需求而發展光源，在發展的歷程中，也發現光對於人在生理上有醫療的效果，因此光學療法常被應用在現代醫學治療上，如治療新生兒黃疸，常需要利用光的能量來幫助其膽紅素的轉化，避免膽紅素對大腦和神經系統引起損害。
本論文利用發光二極體研究新生兒之黃疸治療，探討不同波長的發光二極體對膽紅素的轉化效果，希望能夠減輕光治療對新生兒所產生的副作用，並比較傳統光源與LED對膽紅素的轉化之差異，評估發光二極體應用於新生兒黃疸治療的效益。
從實驗分析結果可以得知，藍光LED之波長最合適用來作為新生兒黃疸治療的光源，給予膽紅素溶液3700 lux的照光7小時後，可使濃度由 17.5 mg/dL下降為 0.3 mg/dL。比較螢光燈光療系統與LED光療系統對膽紅素異構化之效果，LED光療系統對膽紅素溶液照光7小時後，使濃度由 19.5 mg/dL下降為 6.8 mg/dL，螢光燈光療系統對膽紅素溶液照光7小時後，使濃度由 19.8 mg/dL下降為 10.4 mg/dL，由此可看出LED較合適作為新生兒黃疸之照光光源。

From ancient time to now, people have developed different light sources to meet their demand for lighting, such as from early torches to current light emitting diodes (LEDs). With the progress in lighting, it was realized that light could have good medical effects. Therefore, phototherapy is widely used in modern medical treatment, such as the treatment of neonatal jaundice that needs light energy to help the conversion of bilirubin to prevent babies from causing damages in brain and nervous system.

In this study, we research the treatment effectiveness of neonatal jaundice using different wavelengths of LEDs. Experiments were conducted to measure the bilirubin concentration in vitro using samples containing bilirubin. The conversion rate of bilirubin using both traditional light and LEDs are also compared.

The experimental results show that blue LEDs are the most appropriate treatment light source for which bilitubin concentration decreases from 17.5 mg/dL to 0.3 mg/dL under the illumination condition of 3700 lux for 7 hours. In comparison the bilirubin isomerization using either fluorescent lamps and LEDs, the latter light source can reduce the bilirubin concentration from 19.5 mg/dL to 6.8 mg/dL whereas the former from 19.8 mg/dL to 10.4 mg/dL for illumination of 7 hours. Thus, blue LEDs are better for the treatment for neonatal jaundice.

內文目錄
第一章 緒論.........................................1
1.1 前言...........................................1
1.2 研究動機及目的...................................2
1.3 文獻回顧........................................4
第二章 新生兒黃疸症病理原理............................9
2.1 膽紅素代謝機制...................................9
2.2 新生兒黃疸症....................................12
2.2.1 生理性黃疸症..................................12
2.2.2 病理性黃疸症..................................13
2.3 新生兒黃疸症的治療...............................15
2.3.1 藥物治療.....................................15
2.3.2 照光治療.....................................15
2.3.3 換血治療.....................................20
2.4 膽紅素濃度檢驗..................................21
2.4.1 分光光度計法..................................21
2.4.2 偶氮法......................................22
2.4.3 螢光法......................................22
2.4.4 高效率液體層析法..............................23
第三章 LED治療新生兒黃疸效果實驗.......................24
3.1 LED發光原理....................................24
3.2 高功率LED散熱問題...............................27
3.3 光學基本原理....................................28
3.3.1 光學基本單位..................................28
3.3.2 積分球光譜儀	..................................29
3.3.3 照度計.......................................30
3.4 高功率LED......................................31
3.4.1 LED結構......................................31
3.4.2 紅光LED規格...................................32
3.4.3 綠光LED規格...................................33
3.4.4 藍光LED規格...................................34
3.5 LED波長對膽紅素溶液反應實驗........................35
3.5.1吸光值測定法量測膽紅素濃度........................35
3.5.2膽紅素濃度量測工具之量測線........................37
3.5.3不同LED波長對膽紅素溶液反應實驗....................38
3.6 不同強度藍光LED對膽紅素溶液反應實驗..................41
3.7 實驗結果討論.....................................45
3.7.1 不同LED波長對膽紅素異構化實驗討論.................45
3.7.2 藍光LED照光強度對膽紅素異構化實驗討論..............46
第四章 LED照光治療系統研究.............................47
4.1 LED照光治療光源..................................47
4.1.1 LED照光治療系統................................47
4.1.2 LED照光治療系統光學特性.........................50
4.1.3 LED照光治療系統電路架構.........................51
4.2 螢光燈照光治療系統................................53
4.2.1 螢光燈發光原理.................................53
4.2.2 照光治療螢光燈光學特性...........................54
4.2.3 螢光燈電路架構.................................55
4.3 照光治療系統照光均勻性.............................58
4.4 照光治療系統對膽紅素反應實驗........................59
4.5 實驗結果討論.....................................62
4.6 新生兒LED照光治療衣...............................63
第五章 結論與未來展望..................................64
5.1 結論............................................64
5.2 未來展望.........................................65
參考文獻.............................................67
附錄................................................70
 
表目錄
表2.1 為新生兒黃疸症之治療準則..........................14
表3.1 LED磊晶材料與波長對照............................26
表3.2 紅光LED規格參數.................................32
表3.3 綠光LED規格參數.................................33
表3.4 藍光LED規格參數.................................34
表4.1 為LED照光治療系統規格............................47
表4.2 鋁合金1050-H16材料規格表.........................49
表4.3 為螢光燈照光系統規格表............................55
表4.4 LED照光治療系統光照度分佈.........................58
表4.5 螢光燈照光治療系統光照度分佈.......................59

 
圖目錄
圖1.1 六種光源對膽紅素溶液異構化之影響....................5
圖1.2 特殊藍光與藍綠光照光治療效益.......................6
圖1.3 不同照光裝置照光治療效益..........................7
圖1.4 不同強度藍光LED照光治療效益.......................8
圖2.1 膽紅素的代謝機制圖..............................10
圖2.2 膽紅素ⅨΑ之化學結構圖............................11
圖2.3 光照強度下膽紅素下降比率.........................16
圖2.4 黃疸照光治療保溫箱..............................17
圖2.5 黃疸照光治療床.................................17
圖2.6 黃疸照光治療毯.................................18
圖2.7 美國小兒科醫學會照光治療使用準則..................19
圖2.8 美國小兒科醫學會換血治療使用準則..................20
圖2.9 經皮黃疸測試儀.................................21
圖3.1 當V=VF 時，LED注入機制圖.......................24
圖3.2 雙異質接面構造圖...............................25
圖3.3 LED壽命曲線圖.................................27
圖3.4 積分球架構圖..................................30
圖3.5 照度計.......................................31
圖3.6 高功率LED結構圖...............................31
圖3.7 膽紅素莫耳吸光度...............................35
圖3.8 藍光LED測試光源頻譜............................36
圖3.9 膽紅素濃度量測工具.............................36
圖3.10 膽紅素濃度吸光值量測線.........................37
圖3.11 藍光LED對膽紅素溶液吸光值反應...................38
圖3.12 藍光LED對膽紅素溶液濃度反應....................39
圖3.13 綠光LED對膽紅素溶液吸光值反應...................39
圖3.14 綠光LED對膽紅素溶液濃度反應....................40
圖3.15 紅光LED對膽紅素溶液吸光值反應...................40
圖3.16紅光LED對膽紅素溶液濃度反應.....................41
圖3.17 膽紅素溶液照光藍光1850 LUX之吸光值反應..........42
圖3.18 膽紅素溶液照光藍光1850 LUX之濃度反應............42
圖3.19 膽紅素溶液照光藍光3700 LUX之吸光值反應..........43
圖3.20 膽紅素溶液照光藍光3700 LUX之濃度反應............43
圖3.21 膽紅素溶液照光藍光5550 LUX之吸光值反應..........44
圖3.22 膽紅素溶液照光藍光5550 LUX之濃度反應............44
圖3.23 不同LED波長對膽紅素濃度反應比較.................45
圖3.24 藍光LED照光強度對膽紅素濃度反應比較.............46
圖4.1 LED照光治療裝置機構設計........................48
圖4.2 LED照光治療裝置...............................48
圖4.3 LED照光治療系統溫度曲線圖.......................49
圖4.4 LED照光治療系統亮度曲線圖.......................50
圖4.5 A54驅動IC方塊圖...............................51
圖4.6 LED定電流電路圖...............................52
圖4.7 螢光燈結構....................................53
圖4.8 螢光燈照光治療裝置.............................54
圖4.9 照光治療螢光燈發光頻譜圖........................55
圖4.10 螢光燈電路架構圖..............................57
圖4.11 光照度分佈量測區域圖...........................58
圖4.12 LED照光治療系統對膽紅素溶液吸光值反應.............60
圖4.13 LED照光治療系統對膽紅素溶液濃度反應..............60
圖4.14 螢光燈照光治療系統對膽紅素溶液吸光值反應...........61
圖4.15 螢光燈照光治療系統對膽紅素溶液濃度反應.............61
圖4.16 照光治療系統對膽紅素溶液濃度反應..................62
圖4.17 新生兒LED照光治療衣............................63

                                    

[1]S. C. Chou, R. H. Palmer, S. Ezhuthachan, C. Newman, B. Pradell-Boyd, M. J. Maisels and M. A. Testa, "Management of Hyperbilirubinemia in Newborns: Measuring Performance by Using a Benchmarking Model," Pediatrics, vol. 112, no. 6, pp. 1264-1273, 2003.
[2]M. C. Harris, J. C. Bernbaum, J. R. Polin, R. Zimmerman and R. A. Polin, " Developmental Follow-Up of Breastfed Term and Near-Term Infants With Marked Hyperbilirubinemia," Pediatrics, vol. 107, no. 5, pp. 1075-1079, 2001.
[3]S. Ip, M. Chung, J. Kulig, R. O'Brien, R. Sege, S. Glicken, M. J. Maisels, J. Lau and Subcommittee on Hyperbilirubinemia, " An Evidence-Based Review of Important Issues Concerning Neonatal Hyperbilirubinemia," Pediatrics, vol. 114, no. 1, pp. 130-153, 2004.
[4]莊易純， "新生兒出生一週內體重流失率、餵奶方式與黃疸變化的關係"，成功大學，醫學院護理學系碩士論文， 2010.
[5]Stanley Electric Co., "www.stanley-components.com/", 2011.
[6]K. L. Tan, "The Pattern of Bilirubin Response to Phototherapy for Neonatal Hyperbilirubinaemia," Pediatric Research, vol. 16, no. 8, pp. 670-674, 1982.
[7]J. F. Ennever, M. Sobel, A. F. Mcdonagh and W. T. Speck, "Phototherapy for Neonatal Jaundice: in Vitro Comparison of Light Sources," Pediatrics, vol. 18, no. 7, pp. 667-670, 1984.
[8]A. K. Brown, M. H. Kim, P. Y. K. Wu and D. A. Bryla， " Efficacy of Phototherapy in Prevention and Management of Neonatal Hyperbilirubinemia," Pediatrics, vol. 75， pp. 393-400， 1985.
[9]G. Sbrana, G. P. Donzelli and C. Vecchi, " Phototherapy in the Management of Neonatal Hyperbilirubinemia: Efficacy With Light Sources Emitting More Than 500 Nanometers，" Pediatrics， vol. 80， pp. 395-398, 1987.
[10]G. P. Donzellia, S. Pratesi, G. Rapisardi, G. Agati, F. Fusi and Riccardo Pratesi, " 1-day phototherapy of neonatal jaundice with blue-green lamp," The Lancet, vol. 346, pp. 184-185, 1995.
[11]A. Myara, A. Sender, V. Valette, C. Rostoker, D. Paumier, C. Capoulade,F. Loridon, J. Bouillie, J. Milliez, Y. Brossard and F. Trivin, " Early Changes in Cutaneous Bilirubin and Serum Bilirubin Isomers during Intensive Phototherapy of Jaundiced Neonates with Blue and Green Light," Biol Neonate, vol. 71, no. 2, pp. 75-82, 1997.
[12]H. Rosen, A. Rosen, D. Rosen, B. Onaral and M. Hiatt, "Use of a Light Emitting Diode (LED) Array for Bilirubin Phototransformation," Engineering in Medicine and Biology Society, pp. 7266-7268, 2005.
[13]H. J. Vreman, R. J. Wong, J. R. Murdock and D. K. Stevenson, "Standardized bench method for evaluating the efficacy of phototherapy devices," Acta Paediatrica, vol. 97, pp. 308-316, 2008.
[14]陳月枝、黃靜微、林元淑、張綠怡、蔡綠容、林美華、吳佩玲、程子芸、伍雁鈴、吳書雅、許玉雲、王冠今、黃立琪、李慈音、廖珍娟、劉千琪、廖愛華、楊寶圜、蕭慧玲、曾翠華、周治蕙著， "實用兒科護理"，華杏出版社， 2010.
[15]R. M. Kliegman and R. E. Behrman, "Nelson Essentials of Pediatrics," Saunders Company, 1999.
[16]A. Madan, J. R. Mac-Mohan and D. K. Stevenson, "Neonatal hperbilirubinemia," WB Saunders, 2006.
[17]鄧景鴻， "以膽紅素為模版材料之製備及吸附感測之探討"，成功大學，化學工程學系碩士論文， 2003.
[18]T. B. Newman, G. J. Escobar, V. M. Gonzales, M. A. Armstrong, M. N. Gardner and B. F. Folck, " Frequency of Neonatal Bilirubin Testing and Hyperbilirubinemia in a Large Health Maintenance Organization," Pediatrics, vol. 104, no. 2, pp. 1999-1203, 1999.
[19]M. J. Maisels, " Why Use Homeopathic Doses of Phototherapy?" Pediatrics, vol. 98, no. 2, pp. 283-287, 1996.
[20]Zhengzhou Dison Instruction and Meter Co., "http://www.zzdison.com/ ", 2011.
[21]Philips Respironics Co., "http://global.respironics.eu/", 2011.
[22]Subcommittee on Hyperbilirubinemia, " Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation," Pediatrics, vol. 114, no. 1, pp. 297-316, 2004.
[23]Konica Minolta Sensing Co., "http://www.konicaminolta.com/", 2011.
[24]J. Th. G. Overbeek, C. L. J. Vink and H. Deenstra, "The solubility of bilirubin," Centen, 1955.
[25]Y. Andreu, J. Galban and S. D. Marcos, "Determination of direct-bilirubin by fluorimetric-enzymatic method based on bilirubin oxidase," Fresenius Journal of Analytical Chemistry, vol. 368, pp. 516-521, 2000.
[26]C. C. Kuenzle, M. Sommerhalder and J. R. Ruttner, "Separation and quantitative estimation of four bilirubin fractions from serum and of three bilirubin fractions from bile," The Journal of Laboratory and Clinical Medicine , vol. 67, pp. 282-293, 1966.
[27]董德國、陳萬清譯， "光纖通訊"，東華書局， 2001
[28]Cree Inc., " www.cree.com", 2011.
[29]許招墉編譯， "照明設計 "，全華科技圖書， 1999
[30]Tes Electrical Electronic Co., " www.tes.com.tw", 2011.
[31]Epistar Co., " www. epistar.com.tw", 2011.
[32]Nanoforce Technologies Co., " www.nanoforce.com.tw", 2011.

校內：2013-02-16公開
校外：2013-02-16公開

簡易檢索 / 詳目顯示

相關論文