重氮化合物對於化學中佔有其一席之地，不論其衍生物在醫藥化學中的生物活性，或者在有機合成中作為離去基促進鍵與鍵的形成，重氮化合物自最初合成出來至今均一直處在高度討論的狀態，如今雖然有許多合成方式，但是直接以胺基進行重氮化的方式卻沒有再進步，且對官能基的容忍度相當低，如今我們設計一新穎的氮轉移試劑(nitrogen transfer reagent)，預估可藉由此試劑的親電性下，與-胺基酮、-胺基酯及-胺基醯胺等各樣的伯胺(primary amine)形成三氮烯中間體(triazene intermediate)，再進一步於弱鹼的環境下扣環降解成其所相對應的重氮化合物與內醯胺環化合物，此研究將提供更簡單且溫和的重氮化反應試劑，對不同類型胺基均表現相當穩定的產率，在本篇論文中我們也提供了許多未被報導且難以以一般合成方法合成出來的重氮化合物。

Diazo compounds play a very important role in chemistry field. Since the first diazo compound was synthesized, they have been intensively discussed in medicinal applications due to their biological activity and in organic syntheses as an irreversible leaving group participating in bond formations.
Although there were many synthetic methods affording diazo compounds, the straight method from amines with fragile functional groups has not been well developed yet. In here, the intermediate of triazenes constructed from various primary amines such as -amino ketones, -amino esters, and -amino amides with our novel N-transfer reagent could further decompose into corresponding diazo compounds through the intra-molecular lactamization under weak basic environment.
This thesis not only showed a convenient N-transfer reagent reliably generating diazo compounds from various amines but also disclosed several diazo compounds that have never been synthesized in the previous reports.

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