本論文主要以親水性的聚乙二醇與幾丁聚醣混摻形成親水性的混摻膠體，並利用具有醛基或酮基的天然糖類與幾丁聚醣的胺基形成席弗鹼複合物以發展新穎的生醫可降解性高分子材料。本研究所製備的糖反應-幾丁聚醣/聚乙二醇混摻物分為薄膜型與鷹架型。實驗的第一部分先以聚乙二醇混摻幾丁聚醣，並以天然糖類與混摻膜進行梅納反應形成席弗鹼複合物。實驗中以控制混摻膠體的酸鹼值以及熱處理的方式製作糖反應混摻膜進行高分子物性、熱性質、生物降解性質與生物適應性的分析。實驗第二部分以生物可吸收性陶瓷β焦磷酸鈣混合糖反應混摻體分別製成複合膜與多孔鷹架材以強化高分子基質。實驗中β-焦磷酸鈣與糖反應混摻體以不同重量百分比混合製作成膜狀與多孔鷹架狀材料並進行密度測試、孔隙度測試、抗壓強度測試、持水性測試、生物適應性測試、生物降解性分析。
　　本研究第一部份實驗結果顯示，在糖類與幾丁聚醣的胺基間產生imine bond 鍵結(C=N)，而還原糖與混摻膜反應後會降低混摻膜親水性。糖反應混摻膜的平衡水含量依序為蔗糖＞果糖＞葡萄糖。糖反應混摻膜在含有溶菌脢的溶液中具有最好的降解行為。幾丁聚糖、混摻膜以及蔗糖反應混摻膜具有良好的細胞適應性，而果糖與葡萄糖反應混摻膜表面的化學性質與結構抑制了細胞生長。熱處理溫度的增加使糖反應混摻膜的反應度上升並使吸水性下降，同時也改善細胞貼附的行為。高酸鹼值及高濃度的葡萄糖溶液有助於梅納膠體的形成。
　　本研究第二部份實驗結果顯示，複合膜浸泡七天後，其萃取液與纖維母細胞共同培養後細胞數目較控制組快速的增加；此乃因葡萄糖胺與鈣離子自複合膜中釋放所致。當β-DCP含量低於40 wt%時，複合膜之降解行為主要由混摻膠體的酵素分解行為來控制，而當β-DCP含量高於40 wt%時，降解速率主要由低降解速率的β-DCP顆粒與複合材料內物理內鎖結構所控制。此外，以預先冷凍再乾燥的製程可以製造出抗壓強度佳、具有小孔及孔壁連通的結構的多孔性複合鷹架材，且隨著β-DCP添加量的增加複合鷹架材的孔隙率降低而持水性及密度增加。

　　Novel biodegradable chitosan/PEG membrane was prepared by maillard process between chitosan amino group and aldehyde or keto groups of native sugar. Membrane and scaffold type of sugar mediated chitosan/PEG gel have been developed in this research. In part I , by controlling the pH value of sugar, mediating process (surface and solution) and thermal treated temperature, the sugar mediated chitosan/PEG polyblend was prepared. In part II， by mixing bioresorbable b-dicalcium pyrophosphate (b-DCP) ceramic particles to glucose mediated chitosan-Polyethylene glycol (PEG) gel with different weight ratio, the mechanical property of sugar mediated membrane or scaffold was reinforced.
　　The part I results show that the chemical reaction occurrs in imine bonds (C=N) between sugar and amino groups in chitosan. The equilibrium water content (EWC) value of the sugar mediated membrane is in the sequence of sucrose>D-fructose>glucose and they all present much lower water uptake ability than that of polyblend. All of the sugar-mediated membranes are susceptible to lysozyme. However, glucose and d-fructose mediated membranes have a low cell viability impling that their surface chemistry and structure inhibit the cell growth. The thermal treatment promoted the mediating degree and decreased the EWC value of the sugar mediated membrane. In addition, thermal treatment also changed the cell behavior of glucose and d-fructose mediated membrane. The maillard reaction between chitosan and glucose is favored in high pH condition and the glucose mediated membranes prepared by the solution mediated process have a lower EWC than the surface mediated ones.
　　The part II results show that the growth of fibroblasts would increase for the extracts obtained from different b-DCP feeding weight composites after soaking for 7 days. It was found that the glucose amine and calcium are gradually released from the composites, which is considered to be nutritious for the growth of the fibroblast. When the b-DCP content is lower than 40wt%, the degradation behavior is mostly controlled by the dissolution of chitosan/PEG matrix, but as the b-DCP content is larger than 50wt%, the degradation behavior is dominated by the low degradation rate of b-DCP granules and physical interlocking structure of the composite. A well connective channel structure with small pores was obtained by scheme II process and the porosity decreases but water retention and density increase as β-DCP content increases.

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