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研究生： 陳志榮
Chen, za-zon
論文名稱： 流體中奈米微粒自結合傳遞與釋放技術之研發
Development of Nano-Particles Self-Assembling and Seeding Technology in Liquid Carriers
指導教授： 賴新一
Lai, Hsin-Yi Steven
學位類別： 碩士
Master
系所名稱： 工學院 - 機械工程學系
Department of Mechanical Engineering
論文出版年： 2004
畢業學年度： 92
語文別： 中文
論文頁數： 180
中文關鍵詞： 分子動力模擬 、布朗運動 、奈米微粒 、自結合 、擴散 、磁性流體 、釋放 、載體傳遞
外文關鍵詞： Molecular Dynamics simulation, brownian dynamics, assembly, magnetic fluid, nanoparticles, release
相關次數： 點閱：105  下載：9 
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    • 　　早期具特定功能效果之微粒(如藥物)傳遞，大多利用微容器、粉體、流體等載體，經由某些控制機制(如外加電場、流場)以使載體能順利的到達到目的地。利用這類載體充當媒介的傳遞方式，一般難予高效率地將功能性粒子投遞到目的地，且大部分微粒在未到達目的時，即已就被沿途其他的物體(如管壁、器官、空氣)所吸收與分解，不但載體無法傳送到患部，且因其他物體吸收了不需要的微粒，常會造成一些不可預料的副作用，因此如何解決這類問題，提出解決之道，已成為當務之急。問題的癥結主要在於目前尚無一套完整的理論，可供此類研究與預估之用。有鑑於此，本研究乃提出一套奈米微結構自結合傳輸之理論，並針對特定應用，提出一組實測系統，以印證方法之可行性。
    　　針對功能性粒子傳遞中所具備的自結合、載體傳遞與釋放等三個功能，首先將奈米微粒進行表面正或負電性鍍膜，並與表面負或正電性之功能性奈米微粒組成載體；再將此微粒載體投入受體中，配合磁性引導直接將微粒載體運送到目標區域；然後利用特定的釋放機制(如加熱或生物降解特性)讓微粒從載體上脫落，讓功能性粒子從載體上剝離，慢慢地釋放並擴散以通過目標區域的薄膜(如細胞膜)障礙直達目的地，此法可調控目的地所需之功能性微粒數量，使達成最佳的微粒傳遞效果。為完成上述功能的理論建構，本計畫首先採用了DLVO理論，配合電磁與流體力學理論，分別對自結合、載體傳遞與釋放擴散分別建模並加以整合，然後藉由分子動力與布朗動力模擬法，求取參數。
    　　由本文所提之奈米微粒自結合、傳遞與釋放技術之理論估算模型與文獻資料比對，發現其平均誤差皆落在10%內，證明本理論精確可行。利用本研究之模型推估，可準確取得製程參數，預估奈米系統中之微觀參數以改善目前耗時又不經濟的實驗方式，大幅提高生產效率。最後將模擬所推估的數值分別帶入整合模型，即可用以探討各功能間之相關性，並可對微粒傳遞效率進行精算評估，以達到系統模型彈性模組化與電腦速算精確重演之雙重目標，此目標已經由本研究之整合估算，其傳遞效率可以藉由本模型之微調，比以往之效率提高10~15%，證實了此技術是非常有效的。

    　　Traditionally, the delivery of functional particles in liquid media makes good use of capsules, powder and various liquid carriers. Unfortunately, in the traditional ways of delivery, a large portion of functional particles do not arrive at the infected areas. They were decomposed and assimilated by the organs, vessel walls and air bulbs in the way to the infected areas. That is not only inefficient, but also detrimental for bringing in various unexpected side effects to the major system. Thus, how to obtain a better model to allow the delivery process to be more accurately understood and controlled becomes extremely important and urgently needed in many industrial and medical practices.
    　　In view of the need, a new approach by using the nano-particles coating and self-assembled technique is proposed for study. In the functional particles delivery system, three major processes, namely, the self-assembly, the seeding transportion, and the release of nano-particles, are carefully studied. In the self-assembly process, the surface of nano-particles are polarized and then assembled with functional particles to make a complete carrier. In the seeding transportation process, the carrier is injected into the neighborhood of the received zone, and then guided in the fluid flow to the infected areas by using the external magnetic media. In the particles releasing process, the nano-particles were released from the carrier by using either α-ray optical separation or biomedical dissolution techniques. The drug molecules are diffused into the cell membrane of the infected objects with an appropriate control on functional particles supply and seeding effect. In order to model the aforementioned processes, the project employs the theories of DLVO, electromagnetics and hydrodynamics for nanoparticle self-assembly, seeding, releasing and effect tracing. The molecular dynamics is employed to evaluate the process parameters for each of the subprocesses instead of using traditional empirical average values.
    　　The interrelation among these three sub-processes is investigated and an integrated model is proposed. A computerized system is set up to conduct both the numerical and experimental data comparison for signature verification. The results indicate that the modeling procedure proposed in the work is satisfactory.

    中文摘要 I 英文摘要 II 誌謝 III 目錄 IV 圖目錄 IX 表目錄 XV 符號說明 XVI 第一章 緒論 1 1.1 研究動機 1 1.2 研究目的 3 1.3 研究方法 5 1.3.1 自結合模型之研究方法 5 1.3.2 載體傳遞模型之研究方法 7 1.3.3 微粒釋放擴散之研究方法 9 1.4 章節瀏覽 10 第二章 文獻回顧與基本假設 13 2.1 本研究相關之文獻回顧 13 2.1.1 奈米微粒自結合之文獻回顧 13 2.1.2 奈米微粒之磁性傳遞文獻回顧 14 2.1.3 功能性粒子釋放之文獻回顧 15 2.1.4 磁性奈米微粒補助治療之文獻回顧 16 2.1.5 文獻回顧總結 16 2.2 本研究之假設條件 17 2.2.1 奈米微粒自結合之假設條件 18 2.2.2 磁性載體在管路中傳送之假設條件 19 2.2.3 奈米微粒擴散通過薄膜之假設條件 20 第三章 理論模型建構 21 3.1 微粒載體傳送之系統規劃與研究流程 21 3.1.1 微粒載體傳送系統規劃與介紹 21 3.1.2 細部與整合模型架構 26 3.1.3 研究規劃與流程圖 28 3.2 功能性奈米微粒自組裝模型 31 3.2.1 系統動態方程式建構 31 3.2.2 數值分析演算理論與步驟 41 3.2.3 自結合量與其他重要參數之求取 43 3.2.4 自結合之模擬流程 46 3.3 磁性載體傳送模型 48 3.3.1 系統動態方程式建構 48 3.3.2磁場與流場之設定 56 3.3.3 傳遞速率及其他重要參數之求取 59 3.3.4 磁性載體傳遞之模擬流程 62 3.4 功能性奈米微粒擴散釋放模型 65 3.4.1 系統動態方程式之建構 65 3.4.2 數值分析演算理論與步驟 71 3.4.3 通量及其他重要參數之求取 72 3.4.4 奈米微粒釋放之模擬流程 72 3.5 系統整合模型 75 3.5.1 整合系統參數之求取與討論 75 3.5.2 系統整合模型模擬流程 78 第四章 理論模擬結果印證 83 4.1 自結合模擬結果與印證 83 4.1.1 單顆膠體與奈米微粒自結合模擬結果與印證 83 4.1.2 固定濃度的膠體與不同濃度奈米微粒自結合模擬結果 91 4.1.3不同載體尺寸的結合量模擬結果 99 4.2 微粒傳遞模擬結果與印證 105 4.2.1 磁性流體在外加磁場下之微觀結構分析 105 4.2.2 磁性流體在外加磁場下之響應時間估算 110 4.2.3 剪切黏滯係數估算與驗證 114 4.2.4 磁性引導速度估算 119 4.3 微粒釋放模擬結果與印證 123 4.3.1 釋放微觀行為分析和通量估算與印證 123 4.3.2 薄膜擴散係數之求取 130 4.3.3 布朗力對粒子間作用力之影響評估 132 第五章 整合模型應用 137 5.1模型整合之估算與應證 137 5.1.1 初始參數設定 137 5.1.2 自結合模型估算功能性奈米微粒攜帶量 139 5.1.3 傳遞模型預估藥物通量 139 5.1.4 載體集中在受體之密度分佈 143 5.1.5 藥物從載體上的釋放通量估算 144 5.1.6 功能性奈米微粒釋放擴散通量估算 146 5.1.7 整體傳遞效率評估 148 5.1.8 微粒傳遞設計流程 150 5.2應用(一): 磁性分離 152 5.2.1 初始環境規劃 152 5.2.1 參數估算流程與結果 153 5.3 應用(二): 新型生物晶片製作法設計 156 5.3.1 初始環境規劃 156 5.3.2參數估算流程與結果 158 第六章 總結與建議 163 6.1 總結 163 6.2 建議 165 參考文獻 159 附錄A Lengvien方程解析 169

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