電漿醫學的發展在近幾年來有著穩定的成長，在醫學領域的應用上，電漿裝置的型式多為大氣常壓型、非熱型與微小化的微型電漿裝置。此外微電漿於處理目標的效應主要來自於存活期長的活性物種，而在組織中會有處理耐受時間的問題，因此診斷電漿裝置的物種組成、照射環境與組織反應對於生物安全性的探討是十分重要的，對於處理物與處理環境也可以產生較低的負擔。
　　本研究中，將使用電漿噴流型式之氬氣與混和氮氣的微電漿裝置，並藉由調整電漿參數來控制電漿物種組成，於探討曝曬環境的議題上將以通用的國際法規做為準則，而為了模擬組織的反應機制，會使用緩衝溶液與細胞培養液來驗證硝酸鹽類與反應性氧化物種的組成。
　　研究成果呈現出電漿物種的組成，包含(1)紫外光：紫外光譜的不同波段的強度，隨著電漿噴嘴出口與目標物距離增加，紫外光強度隨之遞減，而在距離6 mm的情況下強度將會接近背景值，(2)一氧化氮與臭氧：一氧化氮由於濃度低於量測極限所以無法得知，而臭氧則可以利用累積的方式量測，然而其數值能遠低於安全上限，(3)液相產物：亞硝酸鹽類與反應性氧化物種隨著處理時間增加，其濃度都有增加的趨勢，然而在長時間的處理過程，皆高於我們正常使用的時間參數。
藉由調整電漿參數與處理時間，我們現有使用的微電漿系統可認定為安全且於組織是可忍受的。

“Plasma medicine” has been growingly developed in recent years. For medical applications, a plasma device is usually atmospheric, non-thermal, and miniature as a type of micro-plasmas. Thus, the effect of micro-plasma with a target substance is mostly correlated with relatively long-lived species that may induce an interaction within a tissue-tolerable duration. As the result, the diagnoses of plasma composition, exposed environment, and possibly induced tissue-response are important to clarify the bio-safety issue, though micro-plasmas are known to be weakly loaded to its surrounding and a treated substance. In this study, a jet-type Ar and Ar/N2 micro-plasmas with suggested parameters (with a controlled plasma composition) were utilized, followed by examining the exposed environment, based on general regulations. The induced tissue-response was simulated by loading on a buffer solution and medium, followed by verifying nitrite and reactive oxygen species in liquid. In summary, plasma composition from the suggested device contains (1) UVA, B, and C: the intensities are decreased with the working distance between plasma nozzle and a target substance (e.g., at the working distance of 6 mm, the intensities are close to their background values), (2) the generated nitric oxide, and ozone species: the former ones are not measurable, however, the latter can be accumulated as the exposure time is extended (but still far below the safety range), and (3) the generated species in liquid: nitrite and reactive oxygen species are increased with plasma exposure time, however, it is quite out of the usual plasma exposure time range. Consequently, by adjusting plasma composition and controlling the required exposure time, the currently applied micro-plasma treatment is presumably tissue-tolerable.

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