本研究為探討以Streptococcus zooepidemicus ATCC 39920進行高濃度玻尿酸醱酵之系統。研究發現，隨著菌體量與玻尿酸產量的提升，醱酵液黏度亦大幅增加，此時混合時間(mixing time)為重要參數。吾人建議在進行醱酵生產時，混合時間應控制在30秒以內，可有較好的混合效益，以維持玻尿酸之生產效率。

High concentration hyaluronic acid (HA) fermentation by Streptococcus zooepidemicus ATCC 39920 has been investigated. It was found that, mixing time was an important parameter in this high viscosity system caused by increasing cell density and hyaluronic acid yield. It was suggested that mixing time should be controlled within 30 seconds to maintain HA productivity.

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