| 研究生: |
施佳吟 Shih, Chia-Yin |
|---|---|
| 論文名稱: |
細懸浮微粒(PM2.5)之健康衝擊─平均餘命與健康餘命之分析 The Health Impact of Fine Particulate Matter (PM2.5): An Analysis of Life Expectancy and Healthy Expectancy |
| 指導教授: |
王亮懿
Wang, Liang-Yi |
| 學位類別: |
碩士 Master |
| 系所名稱: |
醫學院 - 公共衛生學系 Department of Public Health |
| 論文出版年: | 2017 |
| 畢業學年度: | 105 |
| 語文別: | 中文 |
| 論文頁數: | 87 |
| 中文關鍵詞: | PM2.5 、細懸浮微粒 、平均餘命 、健康餘命 |
| 外文關鍵詞: | PM2.5, ambient fine particulate matter, life expectancy, healthy expectancy |
| 相關次數: | 點閱:172 下載:17 |
| 分享至: |
| 查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
背景與目的:在工業化發展後,各國在經濟發展歷程中總會面臨到經濟發展與環境問題的角力,台灣也是其中之一,火力發電廠提供能源,石油化學工業帶來經濟產值,卻也排放大量細懸浮微粒。隨著過去空氣汙染歷史事件與科學研究之進展,已有諸多文獻證實細懸浮微粒對健康所造成的負面影響,但過往研究常受限於區域層級資料或研究對象之年齡層,導致無法推論個人或其他群體,也無法針對個人健康狀況與行為進行完整的控制。此外,結合死亡與失能的健康餘命為現今重要評估群體健康的指標之一,但卻鮮少有文獻探討PM2.5對健康餘命的影響。故本研究目的欲以台灣具全國代表性個人追蹤資料探討在控制與平均餘命/健康餘命相關變項後,估算PM2.5對台灣人民之平均餘命與健康餘命造成的衝擊。
方法:本研究自行政院環境保護署取得2005年至2014年PM2.5各監測站數據,並以克利金法推估各鄉鎮市區PM2.5年平均濃度,研究對象取自2005年及2009年國民健康訪問調查中資料完整之收案者。透過串連衛生福利部死因統計檔追蹤至2014年之存活狀況,以Gompertz PH model分析控制教育程度、健康行為與社經地位變項後,估算男、女性各年齡層之死亡風險,並以歐盟所開發之可歸因工具推估男、女性各年齡層各危險因子之不健康比例,最後再以生命表與Sullivan的方法計算高、中、低濃度地區之平均餘命及健康餘命,以及台灣處於高、中、低濃度地區之平均餘命與健康餘命,並估計PM2.5對平均餘命與健康餘命的效應。
結果:(一) PM2.5皆會增加男女性死亡與不健康的危害效應,且對男性的健康效應略大於女性。(二) 當各濃度地區保持一樣的其他危險因子比例時,中、高濃度地區的PM2.5濃度若下降至與低濃度地區相同,中、高濃度地區男性平均餘命可分別因此增加0.751年與0.76年,健康餘命可因此增加0.936年與0.943年;中、高濃度地區女性平均餘命可分別因此增加0.665年與0.638年,健康餘命可因此增加0.565年與0.545年。 (三) 當全台灣從低濃度轉為中、高濃度時,男性將分別因PM2.5損失0.373歲與0.757歲的平均餘命,以及損失0.638年與0.942年的健康餘命;女性則分別因PM2.5提高0.309歲與0.627歲的平均餘命,以及因PM2.5損失0.287年與0.536年的健康餘命。
結論:在各濃度地區不改變其他個人危險因子的狀態下,男性與女性會因PM2.5會降低的平均餘命與健康餘命;且當全台灣從低濃度轉變為中、高濃度時,PM2.5對男性與女性的死亡與健康危害也因此上升,經比較後發現本研究所估算之PM2.5所造成之平均餘命效應較他人研究小,且PM2.5對女性的健康影響較男性小,與過去文獻不符,可能是因未控制種族、個人收入或其他干擾因子所造成,未來仍待更多研究釐清。本篇研究突破過去僅使用區位資料之限制,並提供了PM2.5對台灣人民平均餘命與健康餘命之實證數據,將可作為未來政策擬定與空氣汙染防治之參考。
In the past, many studies found ambient fine particulate matter (PM2.5) increase the risk of disease and mortality. The aim of this study was to examin the adverse health effect of PM2.5 on life expectancy and healthy expectancy in Taiwan.
The PM2.5 concentrations of every township were calculated by Kringing method from 76 monitoring station in Taiwan Air Quality Monitoring Network. Based on the PM2.5 concentrations, townships were divided to high, middle, and low concentration area. The study population from 2005, 2009 National Health Interview Survey (NHIS) for whom 20-year-old to 90-year-old and complete risk factor data.Follow-up duration from interview data to death or alive to 2014. Sex- and age-specific life expectancy (LE) was estimated by multivariable Gompertz PH model and life-table method, sex- and age-specific healthy expectancy (HE) based on self-rated health was estimated by Sullivan’s method.
If other risk factors of high, middle, and low concentration area remain the same proportion, In middle concentration area, PM2.5 reduced LE by 0.751 years and HE by 0.936 years for male, also reduced LE by 0.665 years and HE by 0.565 years for female. In high concentration area, PM2.5 reduced LE by 0.760 years and HE by 0.943 years for male, also reduced LE by 0.638 years and HE by 0.545 years for female. Otherwise, if PM2.5 concentrations in Taiwan rise from low to middle, male would decrease 0.373 years LE and 0.638 years HE, female would decrease 0.309 years LE and 0.287 years HE; if PM2.5 concentrations in Taiwan rise from low to high, male would decrease 0.757 years LE and 0.942 years HE, female would decrease 0.627 years LE and 0.536 years HE.
There may exit potential important confounding factors we didn’t control, including race, income, etc. We provide the evidence of the health impact of PM2.5 on LE and HE in Taiwan, and it would be taken environmental policy as a reference in the future.
Balti, E. V., Echouffo-Tcheugui, J. B., Yako, Y. Y., and Kengne, A. P. (2014). Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 106(2): 161-172. doi:10.1016/j.diabres.2014.08.010
Bell, M. L., Davis, D. L., and Fletcher, T. (2004). A retrospective assessment of mortality from the London smog episode of 1952: The role of influenza and pollution. Environmental Health Perspectives, 112(1): 6-8. doi:10.1289/ehp.6539
Bennett, W. D., Zeman, K. L., and Kim, C. (1996). Variability of fine particle deposition in healthy adults: Effect of age and gender. American Journal of Respiratory and Critical Care Medicine, 153(5): 1641-1647.
Brunekreef, B. (1997). Air pollution and life expectancy: is there a relation? Occupational and Environmental Medicine, 54(11): 781-784.
Brunekreef, B., and Holgate, S. T. (2002). Air pollution and health. Lancet, 360(9341): 1233-1242. doi:10.1016/s0140-6736(02)11274-8
Cancer, I. A. f. R. o. (2013). Outdoor air pollution a leading environmental cause of cancer deaths. IARC Monogr Eval Carcinog Risks Hum 109.
Cann CW, C. M., Gao S. (2005). China’s road to sustainable development. In: Day KA, ed. China ’s Environment and the Challenge of Sustainable Development. . New York, NY: M. E. Sharpe Inc, 3–34.
Chen YC, H. C., Lin SL, et al. (2015). Characteristics of concentrations and metal compositions for PM2.5 and PM2.5-10 in Yunlin county, Taiwan during air quality deterioration. Aerosol and Air Quality Research., 15, 2571-2583.
Chen, Y. M., Lin, W. Y., and Chan, C. C. (2014). The impact of petrochemical industrialisation on life expectancy and per capita income in Taiwan: an 11-year longitudinal study. Bmc Public Health, 14. doi:10.1186/1471-2458-14-247
Chen, Y. Y., Ebenstein, A., Greenstone, M., and Li, H. B. (2013). Evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River policy. Proceedings of the National Academy of Sciences of the United States of America, 110(32): 12936-12941. doi:10.1073/pnas.1300018110
Chen, Z. H., Salam, M. T., Toledo-Corral, C., Watanabe, R. M., Xiang, A. H., Buchanan, T. A., and Gilliland, F. D. (2016). Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans. Diabetes Care, 39(4): 547-554. doi:10.2337/dc15-1795
Correia, A. W., Pope, C. A., Dockery, D. W., Wang, Y., Ezzati, M., and Dominici, F. (2013). Effect of Air Pollution Control on Life Expectancy in the United States An Analysis of 545 US Counties for the Period from 2000 to 2007. Epidemiology, 24(1): 23-31. doi:10.1097/EDE.0b013e3182770237
Cott, C. A., Gignac, M. A. M., and Badley, E. M. (1999). Determinants of self rated health for Canadians with chronic disease and disability. Journal of Epidemiology and Community Health, 53(11): 731-736.
Directorate-General of Budget, A. a. S., Executive Yuan, Taiwan. (2016). Gross production and Deflation index in Taiwan over the past years. Retrieved from https://www.stat.gov.tw/ct.asp?xItem=37407&CtNode=3564&mp=4.
Dockery, D. W., Pope, C. A., Xu, X. P., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E. (1993). AN ASSOCIATION BETWEEN AIR-POLLUTION AND MORTALITY IN 6 UNITED-STATES CITIES. New England Journal of Medicine, 329(24): 1753-1759. doi:10.1056/nejm199312093292401
IfHMaE. (2015). Global Burden Disease Compare. In. Seattle, WA, IHME, University of Washington Retrieved from https://vizhub.healthdata.org/gbd-compare/
Fang, G.-C., Chang, C.-N., Wu, Y.-S., Fu, P. P.-C., Yang, C.-J., Chen, C.-D., and Chang, S.-C. (2002). Ambient suspended particulate matters and related chemical species study in central Taiwan, Taichung during 1998-2001. Atmos Environ, 36(12): 1921- 1928.
Firket, J. (1930). The cause of the symptoms found in the Meuse Valley during the fog of December, 1930. Bull Acad R Med Belg, 11, 683–741.
Gauderman, W. J., Avol, E., Gilliland, F., Vora, H., Thomas, D., Berhane, K., McConnell, R., Kuenzli, N., Lurmann, F., Rappaport, E., Margolis, H., Bates, D., and Peters, J. (2004). The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine, 351(11): 1057-1067. doi:10.1056/NEJMoa040610
Gotschi, T., Heinrich, J., Sunyer, J., and Kunzli, N. (2008). Long-term effects of ambient air pollution on lung function - A review. Epidemiology, 19(5): 690-701. doi:10.1097/EDE.0b013e318181650f
Hamra, G. B., Guha, N., Cohen, A., Laden, F., Raaschou-Nielsen, O., Samet, J. M., Vineis, P., Forastiere, F., Saldiva, P., Yorifuji, T., and Loomis, D. (2014). Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis. Environmental Health Perspectives, 122(9): 906-911. doi:10.1289/ehp.1408092
Hayes, A. J., Leal, J., Kelman, C. W., and Clarke, P. M. (2011). Risk equations to predict life expectancy of people with Type 2 diabetes mellitus following major complications: a study from Western Australia. Diabetic Medicine, 28(4): 428-435. doi:10.1111/j.1464-5491.2010.03189.x
KA, M., DS, S., L, S., K, S., JH, S., GL, A., and JD, K. (2007). Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med, 356(5): 447-458.
Kampa, M., and Castanas, E. (2008). Human health effects of air pollution. Environ. Pollut., 151(2): 362-367. doi:10.1016/j.envpol.2007.06.012
Kelly, F. J., and Fussell, J. C. (2015). Air pollution and public health: emerging hazards and improved understanding of risk. Environmental Geochemistry and Health, 37(4): 631-649. doi:10.1007/s10653-015-9720-1
Kelly, P. J., Clarke, P. M., Hayes, A. J., Gerdtham, U. G., Cederholm, J., Nilsson, P., Eliasson, B., and Gudbjornsdottir, S. (2014). Predicting mortality in people with Type 2 diabetes mellitus after major complications: a study using Swedish National Diabetes Register data. Diabetic Medicine, 31(8): 954-962. doi:10.1111/dme.12468
Ko, Y. C., Cheng, L. S. C., Lee, C. H., Huang, J. J., Huang, M. S., Kao, E. L., Wang, H. Z., and Lin, H. J. (2000). Chinese food cooking and lung cancer in women nonsmokers. American Journal of Epidemiology, 151(2): 140-147.
Kowalski, M., Kowalska, K., and Kowalska, M. (2016). HEALTH BENEFITS RELATED TO THE REDUCTION OF PM CONCENTRATION IN AMBIENT AIR, SILESIAN VOIVODESHIP, POLAND. International Journal of Occupational Medicine and Environmental Health, 29(2): 209-217.
Ku¨nzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L,Gilliland F, Thomas D, Peters J, Hodis HN. (2005) Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect, 113(2): 201–206.
Krewski D, J. M., Burnett RT, Ma R, Hughes E, Shi Y, Turner MC, Pope CA 3rd, Thurston G, Calle EE, Thun MJ, Beckerman B, DeLuca P, Finkelstein N, Ito K, Moore DK, Newbold KB, Ramsay T, Ross Z, Shin H, Tempalski B. ( 2009). Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality. Res Rep Health Eff Inst., (140):5-114.
Lee, E. T., and Go, O. T. (1997). Survival analysis in public health research. Annual Review of Public Health, 18, 105-134. doi:10.1146/annurev.publhealth.18.1.105
Lepeule, J., Laden, F., Dockery, D., and Schwartz, J. (2012). Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009. Environmental Health Perspectives, 120(7): 965-970. doi:10.1289/ehp.1104660
Li, K. R., Husing, A., and Kaaks, R. (2014). Lifestyle risk factors and residual life expectancy at age 40: a German cohort study. Bmc Medicine, 12. doi:10.1186/1741-7015-12-59
Liu, C. Q., Ying, Z. K., Harkema, J., Sun, Q. H., and Rajagopalan, S. (2013). Epidemiological and Experimental Links between Air Pollution and Type 2 Diabetes. Toxicologic Pathology, 41(2): 361-373. doi:10.1177/0192623312464531
Lo, W. C., Shie, R. H., Chan, C. C., and Lin, H. H. (2017). Burden of disease attributable to ambient fine particulate matter exposure in Taiwan. Journal of the Formosan Medical Association, 116(1): 32-40. doi:10.1016/j.jfma.2015.12.007
Loddenkemper, R., Gibson, G. J., and Sibille, Y. (2003). The burden of lung disease in Europe: Why a European White Book on lung disease? European Respiratory Journal, 22(6): 869-869. doi:10.1183/09031936.03.00107803
Logan, Wp. (1953). Mortality in the London fog incident, 1952. Lancet. , 14;1(6755):336-8.(0140-6736 (Print)): 336-338.
Lung, S. C. C., Mao, I. F., and Liu, L. J. S. (2007). Residents' particle exposures in six different communities in Taiwan. Science of the Total Environment, 377(1): 81-92. doi:10.1016/j.scitotenv.2007.01.092
Nevalainen, J., and Pekkanen, J. (1998). The effect of particulate air pollution on life expectancy. Science of the Total Environment, 217(1-2): 137-141. doi:10.1016/s0048-9697(98)00172-7
Olshansky, S. J., and Carnes, B. A. (1997). Ever since Gompertz. Demography, 34(1): 1-15. doi:10.2307/2061656
Organization, W. H. (2006). Air quality guidelines: global update 2005: particulate matter, ozone, nitrogen dioxide, and sulfur dioxide.
Patricia M. Grambsch and Terry M. Therneau. (1994). Proportional hazards tests and diagnostics based on weighted residuals. Biometrika, 81(3): 515-526.
Pope, C. A., Burnett, R. T., Thun, M. J., Calle, E. E., Krewski, D., Ito, K., and Thurston, G. D. (2002). Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. Jama-Journal of the American Medical Association, 287(9): 1132-1141. doi:10.1001/jama.287.9.1132
Pope, C. A., Ezzati, M., and Dockery, D. W. (2009). Fine-Particulate Air Pollution and Life Expectancy in the United States. New England Journal of Medicine, 360(4): 376-386. doi:10.1056/NEJMsa0805646
Pope, C. A., Thun, M. J., Namboodiri, M. M., Dockery, D. W., Evans, J. S., Speizer, F. E., andHeath, C. W. (1995). Particulate air-pollution as a predictor of mortality in a prospective-study of US adults. American Journal of Respiratory and Critical Care Medicine, 151(3): 669-674.
Rajagopalan, S., and Brook, R. D. (2012). Air Pollution and Type 2 Diabetes Mechanistic Insights. Diabetes, 61(12): 3037-3045. doi:10.2337/db12-0190
Rice, M. B., Ljungman, P. L., Wilker, E. H., Dorans, K. S., Gold, D. R., Schwartz, J., Koutrakis, P., Washko, G. R., O'Connor, G. T., and Mittleman, M. A. (2015). Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine, 191(6): 656-664. doi:10.1164/rccm.201410-1875OC
Ruckerl, R., Schneider, A., Breitner, S., Cyrys, J., and Peters, A. (2011). Health effects of particulate air pollution: A review of epidemiological evidence. Inhalation Toxicology, 23(10): 555-592. doi:10.3109/08958378.2011.593587
Scheers, H., Jacobs, L., Casas, L., Nemery, B., and Nawrot, T. S. (2015). Long-Term Exposure to Particulate Matter Air Pollution Is a Risk Factor for Stroke Meta-Analytical Evidence. Stroke, 46(11): 3058-3066.
Schikowski, T., Adam, M., Marcon, A., Cai, Y. T., Vierkotter, A., Carsin, A. E., Jacquemin, B., Al Kanani, Z., Beelen, R., Birk, M., Bridevaux, P. O., Brunekeef, B., Burney, P., Cirach, M., Cyrys, J., de Hoogh, K., de Marco, R., de Nazelle, A., Declercq, C., Forsberg, B., Hardy, R., Heinrich, J., Hoek, G., Jarvis, D., Keidel, D., Kuh, D., Kuhlbusch, T., Migliore, E., Mosler, G., Nieuwenhuijsen, M. J., Phuleria, H., Rochat, T., Schindler, C., Villani, S., Tsai, M. Y., Zemp, E., Hansell, A., Kauffmann, F., Sunyer, J., Probst-Hensch, N., Kramer, U., and Kunzli, N. (2014). Association of ambient air pollution with the prevalence and incidence of COPD. European Respiratory Journal, 44(3): 614-626. doi:10.1183/09031936.00132213
Scovronick N, F. D., Alonso M, Almeida C, Longo K, Freitas S, Rudorff B, Wilkinson P. (2016). Air Quality and Health Impacts of Future Ethanol Production and Use in São Paulo State, Brazil. Int J Environ Res Public Health., 13(7).
Seow, A., Poh, W. T., Teh, M., Eng, P., Wang, Y. T., Tan, W. C., Yu, M. C., and Lee, H. P. (2000). Fumes from meat cooking and lung cancer risk in Chinese women. Cancer Epidemiology Biomarkers & Prevention, 9(11): 1215-1221.
Shrenk HH, H. H., Clayton GD. (1949). Air Pollution in Donora, Pa.: Epidemiology of the Unusual Smog Episode of October 1948. Preliminary Report. Washington, DC: US Public Health Service; 1949. Public Health Bulletin No. 306.
Stieb, D. M., Judek, S., van Donkelaar, A., Martin, R. V., Brand, K., Shin, H. H., Burnett, R. T., and Smith-Doiron, M. H. (2015). Estimated public health impacts of changes in concentrations of fine particle air pollution in Canada, 2000 to 2011. Canadian Journal of Public Health-Revue Canadienne De Sante Publique, 106(6): E362-E368.
Strak, M., Janssen, N., Beelen, R., Schmitz, O., Karssenberg, D., Houthuijs, D., van den Brink, C., Dijst, M., Brunekreef, B., and Hoek, G. (2017). Associations between lifestyle and air pollution exposure: Potential for confounding in large administrative data cohorts. Environmental Research, 156, 364-373. doi:10.1016/j.envres.2017.03.050
Sunyer, J., Schwartz, J., Tobias, A., Macfarlane, D., Garcia, J., and Anto, J. M. (2000). Patients with chronic obstructive pulmonary disease are at increased risk of death associated with urban particle air pollution: A case-crossover analysis. American Journal of Epidemiology, 151(1): 50-56.
Taiwan Air Quality Monitoring Network. Retrieved from http://taqm.epa.gov.tw/taqm/tw/YearlyDataDownload.aspx
Vienneau, D., Perez, L., Schindler, C., Lieb, C., Sommer, H., Probst-Hensch, N., Kunzli, N., and Roosli, M. (2015). Years of life lost and morbidity cases attributable to transportation noise and air pollution: A comparative health risk assessment for Switzerland in 2010. International Journal of Hygiene and Environmental Health, 218(6): 514-521. doi:10.1016/j.ijheh.2015.05.003
Wang, Y., Shi, L. H., Lee, M., Liu, P. F., Di, Q., Zanobetti, A., and Schwartz, J. D. (2017). Long-term Exposure to PM2.5 and Mortality Among Older Adults in the Southeastern US. Epidemiology, 28(2): 207-214. doi:10.1097/ede.0000000000000614
Wen, M., and Gu, D. N. (2012). Air Pollution Shortens Life Expectancy and Health Expectancy for Older Adults: The Case of China. J. Gerontol. Ser. A-Biol. Sci. Med. Sci., 67(11): 1219-1229. doi:10.1093/gerona/gls094
Yang, C. M., and Kao, K. (2013). Reducing Fine Particulate to Improve Health: A Health Impact Assessment for Taiwan. Archives of Environmental & Occupational Health, 68(1): 3-12. doi:10.1080/19338244.2011.619216
莊秉潔、郭珮萱 (2011)。 石化產業的空污與健康風險。生態臺灣(30),頁 20-32。
莊秉潔、郭珮萱、古鎧禎、鄭逸瑋、李泓錡 (2014)。 PM2.5與石化產業。
吳依凡 (2004)。醫療資源可近性對個人醫療利用的影響─台灣地區的實證研究。(碩士論文)。國立中央大學。