本研究以集總參數模型進行血液動力學的分析，從高血壓以及心房顫動的分析結果揭示造成缺血性腦中風的原因，並觀察大腦前、中、後大動脈栓塞時對於腦部血液動力學的影響。在本研究中發現平均動脈壓對栓塞後下降的腦動脈壓力和流量具有正向的影響，即隨著平均動脈的提升，腦大動脈和遠端小動脈的壓力和流量從一開始的嚴重下降，逐漸恢復至未栓塞狀態下的壓力和流量，甚至有可能高於未栓塞時的狀態。值得注意的是，平均動脈壓的上升對於大動脈具有較顯著的影響，但是對於遠端小動脈的影響較不顯著。在栓塞病例中，最重要的就是觀察遠端小動脈的流量，因為小動脈的主要功能是向腦部不同功能區域進行血流灌注。因此遠端小動脈的流量提升對於缺血性中風病患至關重要，但是由靈敏度分析結果發現，大動脈壓力具有最高的靈敏度係數，而小動脈流量的靈敏度係數僅高於栓塞處的大動脈流量，表示在平均動脈壓上升時，對恢復遠端小動脈的血流量灌注具有正向的影響，但代價就是可能造成大動脈的血壓和未栓塞處的大動脈流量大幅度上升，提高發生腦水腫和出血性轉化的風險。總而言之，本研究針對腦動脈栓塞患者平均動脈壓上升，對腦動脈血液灌注的影響提出血液動力學的觀點，並展示了恢復遠端小動脈血液灌注時對於其他腦動脈的影響。進一步為臨床上缺血性中風患者的診治與評估提出血液動力學的結果，以數值化展示血壓和血流量的方式輔助 CT 造影，為中風患者提出詳細的診斷結果。

This study analyzed the hemodynamics using a lumped-parameter model to investigate the causes of ischemic stroke based on hypertension and atrial fibrillation. In this study, it was found that the mean arterial pressure (MAP) had a positive effect on the decrease in cerebral arterial pressure and flow rate after occlusion. It is worth noting that the increase in MAP had a more significant effect on large arteries but a less significant effect on distal arterioles. Sensitivity analysis results revealed that arterial pressure had the highest sensitivity coefficient, while the sensitivity coefficient of distal arteriole flow rate was only higher than that of the occluded large artery flow rate. This indicates that an increase in MAP has a positive effect on restoring blood flow perfusion in distal arterioles. However, the potential trade-off is a substantial increase in blood pressure in large arteries and flow rate in non-occluded areas, which increases the risk of cerebral edema and hemorrhagic transformation. In conclusion, this study provides a hemodynamic perspective on the effect of an increase in mean arterial pressure on cerebral blood perfusion in patients with cerebral artery occlusion. It also demonstrates the effects of restoring blood perfusion in distal arterioles on other cerebral arteries. Furthermore, it presents hemodynamic results to assist in the diagnosis and assessment of ischemic stroke patients by numerically displaying blood pressure and blood flow rate in conjunction with CT imaging, providing detailed diagnostic outcomes for ischemic stroke patients.

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