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研究生: 陳李成
Cheng, Lee
論文名稱: 以資料探勘模組建立之心血管異常預測系統
Development of a Data Mining System for Predicting Cardiovascular Anomalies
指導教授: 曾新穆
Tseng, Vincent S.
學位類別: 碩士
Master
系所名稱: 電機資訊學院 - 資訊工程學系
Department of Computer Science and Information Engineering
論文出版年: 2008
畢業學年度: 96
語文別: 中文
論文頁數: 39
中文關鍵詞: 心血管異常心電圖資料探勘病患監測系統
外文關鍵詞: Patient monitoring system, Data mining, Electrocardiograph (ECG), Cardiovascular anomaly
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  • 近年來全球人口結構持續朝向高齡化情形發展,以及民眾對健康與生活品質之日
    趨重視,促成預防醫學的興起,對於需要照護的病患提供醫療照護相關產品或技術的
    研究與發展,更是有其重要的意義與利基。針對心血管疾病患者,隨時留意其生理訊
    號重要的變化,在病患發生重大病症之前及時提供警訊,能在最短時間內,進行合適
    的病症處置或者緊急送醫的程序,對於挽救病患的寶貴生命及減少病症所造成的健康
    損害將有極大之助益。
    本論文設計了一套整合多種方法的資料探勘發病預測模組,以平台化的方式進行
    資料處理分析,同時提供彈性化的擴充架構以便平台結合更多種不同的處理方法。本
    研究以心血管疾病的資料作為實驗對象,讓醫生可以藉由此系統,判讀病患的心電圖
    狀況,系統再根據病患所登錄的心電圖資訊,結合多種分類器來判定病患是否有異常
    發生,進而可早期通知醫生該病患是否可能發生異常狀況。我們以心房早期顫動
    (PAF),長時間ST 型缺血性心臟病(LTST),與分類病患年齡之資料(Fantasia Database)
    多種資料來驗證正確度,經多次實驗結果顯示本系統可達成良好之心電準確率
    (E-Precision)與心電涵蓋率(E-Recall)。實驗結果證明本系統相較於現存醫學角度之研
    究,提供了不同方法的結果,並成功整合了多種資料探勘方法,同時也能穩定的判定
    病患的心電圖異常的可能。

    In recent years, the structure of global population keeps going towards highly-aged continuously. The development of a medical care system becomes important and meaningful since people paid a lot of attentions on patients. A medical care system is designed to provide alerts before the severe illnesses occurred and necessary procedures could be taken in short time to save one precious life.

    In this thesis, we presented a data mining system for patient monitoring with applications on caring the cardiovascular patients. This system was established by integrating various methods into a platform-like architecture with high flexibility. By mining vital signs like ECG, the system could predict possible anomalies so that doctors can be informed to take early actions. The experimental results showed that our proposed system delivered good performance in terms of E-precision and E-recall under different datasets. Our studies showed that this system could integrate different methods and stably predict the anomaly from patients’ ECG data without coding of medical rules as done in other existing approaches.

    中文摘要 I 英文摘要 II 誌謝 III 圖目錄 VI 表目錄 VI 第一章 導論 1 1.1 研究背景 1 1.2 研究動機 2 1.3 問題描述 2 1.4 研究方法 2 1.5 論文架構 4 第二章 文獻探討 5 2.1 生理監測系統發展進程 5 2.2 生理訊號簡介與心血管疾病:以心電圖為例 6 2.3 資料探勘技術簡介 7 2.3.1 分類樹探勘法(Classification Mining on Decision Tree) 7 2.3.2 貝式機率探勘法(Classification Mining on Bayesian Classifier) 11 2.3.3 多重分類器 12 第三章 整合性生理訊號探勘系統 14 3.1 一般化心電圖資料探勘概念與特性 14 3.2 一般化心電圖資料探勘之定義 14 3.3 一般化心電圖資料探勘之目的 15 3.4 整合性生理訊號探勘系統 17 3.4.1 一般化心電圖資料探勘-前處理階段 17 3.4.2 整合性生理訊號探勘系統─讀取界面 19 3.4.3 整合性生理訊號探勘系統─特徵擷取界面 20 3.4.4 整合性生理訊號探勘系統─特徵選取界面 20 3.4.5 一般化心電圖資料探勘-探勘階段 22 3.4.6 整合性生理訊號探勘系統─分類模組界面 23 第四章 實驗分析 24 4.1 實驗相關參數與評估方式說明 24 4.2 PAF實驗評估 25 4.2.1 PAF實驗資料說明 25 4.2.2 極端特徵值統計區間實驗 25 4.2.3 多分類模組實驗 25 4.2.4 特徵屬性數量 27 4.2.5 加權值實驗分析 28 4.2.6 生理訊號時間長短實驗分析 28 4.2.7 PAF實驗結果 29 4.3 LTST實驗評估 30 4.3.1 LTST實驗資料說明 30 4.3.2 極端特徵值統計區間實驗 30 4.3.3 LTST實驗結果 31 4.4 FANTASIA實驗評估 31 4.4.1 Fantasia實驗資料說明 31 4.4.2 Fantasia實驗結果 31 4.5 實驗總結 32 第五章 結論與未來研究方向 33 5.1 結論 33 5.2 未來研究方向 35 參考文獻 36 自述 39

    [1] F. Alonso, J. P. Caraca-Valente, L. Martinez, C.Montes, “Discovering Similar Patterns for Characterizing Time Series in a Medical Domain,” in Proc. of IEEE International Conference on Data Mining, 2001.
    [2] E. Bauer, R. Kohavi, ”An Empirical Comparison of Voting Classification Algorithms: Bagging, Boosting, and Variants,” Machine Learning, 1999.
    [3] L. Breiman, ” Bagging Predictors,” Machine Learning, 1994.
    [4] J. R. Chen, ”Making Subsequence Time Series Clustering Meaningful,” in Proc. of IEEE International Conference on Data Mining, 2005.
    [5] E. Frank, M. A. Hall, G. Holmes, R. Kirkby, B. Pfahringer, “Weka - A Machine Learning Workbench for Data Mining,” Springer, 2005.
    [6] Y. Freund, R. E. Schapire, “A Decision-theoretic Generalization of On-line Learning and an Application to Boosting,” Computational Learning Theory: Second European Conference, 1995.
    [7] N. Friedman, D. Geiger, M. Goldszmidt, ”Bayesian Network Classifiers,” Machine Learning, 1997.
    [8] R. Jafari, F. Dabiri, P. Brisk, M. Sarrafzadeh, ”Reconfigurable Fabric Vest for Fatal Heart Disease Prevention,” Embedded Computing,2005.
    [9] E. Keogh, J. Lin, W. Truppel, “Clustering of Time Series Subsequences is Meaningless: Implication for Previous and Future Research,” Knowledge and Information Systems, 2005.
    [10] P. Langley, E. J. Bowers, J. Wild, M. J. Drinnan, J. Allen, A. Sims, N. Brown, A. Murray, “An Algorithm to Distinguish Ischaemic and Non Ischaemic ST Changes in the Holter ECG,” in Proc. of Computers in Cardiology, 2003.
    [11] H. G. Lee, K. Y. Noh, H. K. Park, K. H. Ryu, “Predicting Coronary Artery Disease from Heart Rate Variability Using Classification and Statistical Analysis,” International Conference in Computer and Information Technology, 2007.
    [12] F. Y. Lin, S. McClean, “A Data Mining Approach to the Prediction of Corporate Failure,” Knowledge-Based Systems, 2001.
    [13] J. N. McNames, A. M. Fraser, “Obstructive Sleep Apnea Classification Based on Spectrogram Patterns in the Electrocardiogram,” in Proc. of Computers in Cardiology, 2000.
    [14] T. Nguyen, I. Bass, M. Li, I. K. Sethi, “Investigation of Combining SVM and Decision Tree for Emotion Classification,” in Proc. of IEEE International Symposium on Multimedia, 2005.
    [15] T. L. Pao, C. S. Chien, Y. T. Chen, J. H. Yeh, Y. M. Cheng, W. Y. Liao, “Combination of Multiple Classifiers for Improving Emotion Recognition in Mandarin Speech,” Intelligent Information Hiding and Multimedia Signal Processing, 2007.
    [16] T. Penzel, J. McNames, A. Murray, P. de Chazal, G. Moody, B. Raymond, ”Systematic Comparison of Different Algorithms for Apnoea Detection Based on Electrocardiogram Recordings,” Medical and Biological Engineering and Computing, 2002.
    [17] S. Petrutiu, A. V. Sahakain, J. Ng, S. Swiryn, “Analysis of the Surface Electrocardiogram to Predict Termination of Atrial Fibrillation: The 2004 Computers in Cardiology/PhysioNet Challenge,” in Proc. of Computers in Cardiology, 2004.
    [18] R. J. Povinelli, ”Towards the Prediction of Transient ST Changes,” in Proc. of Computers in Cardiology, 2005.
    [19] B. Puers, W. Sansen, K. U. Leuven, ”Patient Monitoring Systems,” VLSI and Microelectronic Applications in Intelligent Peripherals and their Interconnection Networks, 1989.
    [20] J. R. Quinlan, “Induction of Decision Trees,” Machine Learning, 1986.
    [21] J. R. Quinlan, “C4.5: Programs for Machine Learning,” Morgan Kaufmann Publishers, 1993.
    [22] T. Thong, “Prediction of Paroxysmal Atrial Fibrillation by Analysis of Atrial Premature Complexes,” in IEEE Transactions on Biomedical Engineering, 2004.
    [23] R. Watrous, G. Towell, “A Patient Adaptive Neural Network ECG Patient Monitoring Algorithm,” in Proc. of Computers in Cardiology,1995.
    [24] M. Wiggins, A. Saad, B. Litt, G. Vachtsevanos, “Evolving a Bayesian Classifier for ECG-based Age Classification in Medical Applications,” Applied Soft Computing, 2008.
    [25] J. G. Wolff, “Medical Diagnosis as Pattern Recognition in a Framework of Information Compression by Multiple Alignment, Unification and Search,” Decision Support Systems, 2005.
    [26] M. W. Zimmerman, R. J. Povinelli, ”On Improving the Classification of Myocardial Ischemia Using Holter ECG Data,” in Proc. of Computers in Cardiology, 2004.
    [27] W. Zong, R. Mukkamala, R. G. Mark, “A Methodology for Predicting Paroxysmal Atrial Fibrillation Based on ECG Arrhythmia Feature Analysis,” in Proc. of Computers in Cardiology, 2001.
    [28] 馬芳資,林我聰, “決策樹形式知識之線上預測系統架構,” Library and Information Science,2003.
    [29] Computers in Cardiology Challenge 2001 Top Scores, http://www.physionet.org/challenge/2001/top-scores.shtml
    [30] The Long-Term ST Database, http://www.physionet.org/physiobank/database/ltstdb/
    [31] Fantasia Database, http://www.physionet.org/physiobank/database/fantasia/
    [32] PAF Database, http://www.physionet.org/physiobank/database/afpdb/
    [33] PhysioNet, http://www.physionet.org/

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