在本篇論文中，成功的製造出具有磁性之中孔洞雙邊不對稱球體，使其在磁場下能進行操控。磁性雙邊不對稱球體是以粒徑為480奈米之二氧化矽球體作為初始材料，在表面吸附上聚乙烯吡咯烷酮作為保護層，以改變其在氫氧化鈉水溶液環境下的蝕刻行為。此外也發現在不改變二氧化矽球體粒徑的前提下，以低溫進行蝕刻有較佳的蝕刻速率。為了在二氧化矽之孔洞中合成磁性顆粒，將含有三價鐵離子及二價鐵離子之化學前驅物導入二氧化矽球體之中孔洞中，在鹼性溶液中進行合成反應。藉由特殊的分離方式純化磁性之中孔洞二氧化矽顆粒，並移除溶液中含有之三氧化四鐵顆粒、未反應物及其他雜質。利用本實驗室團隊所開發之包含陷入及表面改質之連續製程，可將磁性中孔洞二氧化矽球體之半球表面進行氨基改質，並利用金的奈米粒子作為標記，可在穿透式電子顯微鏡下判別有較多氨基之半球表面。另外也對此種新穎的磁性中孔洞雙邊不對稱球體進行其他材料性質的分析。

In this research work, magnetic mesoporous Janus particles were fabricated for the manipulation of these Janus particles under the magnetic field. These Janus particles corded with 480 nm silica colloids were first adsorbed with poly(vinyl pyrrolidone) (PVP) as the surface protecting layer that altered the silica etching process under the aqueous NaOH solution. It was also found that the etching process at low temperature provided optimized etching rate with no change in the diameter of these silica colloids. The chemical precursors for the synthesis of magnetic particles, including ferric ions and ferrous ions were introduced into the pores of the mesoporous silica colloids, followed by the synthetic reaction in the base solution. Special separation was carried out to separate the magnetic mesoporous silica particles from the reaction solution, which contained pure Fe3O4 particles, unreacted reagents, and other impurities. These magnetic mesoporous silica particles were then utilized in the sequential embedding and surface modification processes developed in this team that hemispherically functionalized the silica with amino groups. Using gold nanoparticles as the labeling agents, it became possible to identify the amino-enriched hemisphere under the TEM images. Other material characterizations were also conducted to analyze these novel magnetic mesoporous Janus particles.

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