癲癇為一種常見的神經性疾病，全世界約有五千萬人受其影響。現今最常見的癲癇治療方式為抗癲癇藥物和切除手術，然而約有三成的病患無法透過藥物得到有效的治療。醫療人員因此改由其他方式如電刺激嘗試醫治癲癇。高頻電刺激抑制癲癇的機轉目前雖尚不明確，但已有許多動物和臨床實驗證實其可有效舒緩或抑制癲癇發作。近年來出現穿顱亂數電刺激的研究，以雜訊刺激實驗對象腦區，發現其可增強受試者的學習能力或是改善某些疾病，然而關於亂數電刺激治療癲癇之研究卻相對缺乏。本研究的目的即藉由動物實驗確認深腦限頻亂數電刺激治療癲癇發作的效果。

　　本研究使用海藻酸誘發小鼠癲癇發作後，以頻帶介於 101-640 Hz 之頻帶侷限白雜訊和 128 Hz 之規律高頻訊號刺激小鼠海馬迴 CA3 區，再由訊號能量帶功率、Teager 能量運算子、樣本熵、CSC 卡爾曼濾波器等演算法評估上述電刺激方式治療癲癇的成效。結果顯示限頻亂數電刺激於刺激過程中可舒緩癲癇，但於刺激結束後的短時間內可能加劇癲癇發作，規律高頻電刺激在刺激過程中同樣有舒緩癲癇的效果，在刺激結束後對於小鼠癲癇的影響本研究則需要進行更多次實驗才能確認。除了上述結果，本研究也應用支援向量機判定癲癇抑制成功與否和抑制持續時間，實驗結果顯示限頻亂數電刺激在刺激過程中抑制癲癇發作的成功率較規律高頻電刺激高，但持續抑制癲癇的時間較規律高頻電刺激短。總而言之，本研究認為限頻亂數電刺在治療小鼠癲癇發作上的效果不比規律高頻電刺激差，為未來值得繼續嘗試或研究的方法。

Epilepsy is a common neurological disorder that affects many people worldwide. The most common epilepsy treatments today include antiepileptic drugs and resection surgery, yet about 30% of patients cannot be effectively treated with drugs. Medical professionals have therefore been turning to other modalities such as electrical stimulation for controlling seizure. The mechanism of deep brain high-frequency stimulation to suppress seizures is still unknown, but many animal and clinical studies have demonstrated its effectiveness in relieving or suppressing seizures. In recent years, there have been studies about transcranial random noise stimulation (tRNS), where band-limited white noise is used to stimulate subjects' brain. It was found that tRNS can enhance the subjects' learning ability or ease certain disorders, however, there is a relative lack of research of random noise stimulation on treating epileptic seizure. The purpose of this study is to confirm the effect of deep brain band-limited random noise stimulation on controlling epileptic seizure through animal experiments. 20 kainic acid-induced mice were recruited in this experiment, and the CA3 region of the hippocampus were stimulated with band-limited white noise with a frequency band between 101-640 Hz, or regular high-frequency signal at 128 Hz for 5 seconds while the subjects were having seizures. The effectiveness of these deep brain stimulation modalities in treating seizure was evaluated by the band power of the electroencephalography signals, or algorithms such as Teager energy operator, sample entropy, and constrained square-root cubature Kalman filter. The results show that band-limited random noise stimulation can relieve seizures during stimulation but may exacerbate them within a short period of time after stimulation. Regular high-frequency stimulation also has the effect of alleviating seizures during the stimulation process. The effect of regular high-frequency stimulation on seizure in mice after the stimulation may need further experimental studies. In addition, this study also utilized support vector machine to determine if seizure is suppressed during stimulation. The results show that band-limited random noise stimulation is more successful in suppressing seizures than regular high-frequency stimulation, but the duration of seizure suppression is shorter than that of regular high-frequency stimulation.
In conclusion, band-limited random noise stimulation is no less effective than regular high-frequency stimulation in the treatment of epileptic seizure in mice and is a method worthy of further investigation or study in the future.

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