支氣管肺發育不全(BPD) 是一種影響早產兒的呼吸道疾病。本研究透過廣義線性模型(GLM) 探討影響BPD的重要因子，試圖了解出生後首月的成長軌跡與胎齡36週時BPD發生之關聯性。
本篇論文採用回溯性研究，透過國立成功大學醫學院附設醫院(NCKUH) 的非常早產兒樣本，並根據National Institute of Child Health and Human Development(NICHD)於西元2000年6月舉辦的研討會對胎齡36週時的BPD定義。GLM 結合產前和產後的重要因子與BPD發生的關聯性，本篇研究針對文中所提出的體重成長率討論，由於大部分的重要因子是難以控制的，但體重成長率是一個有機會透過營養介入來改善的因子。結果顯示，當早產兒為男性、較低出生週數(GA)、第1 天至第28 天(D1 –D28) 的較低體重成長率、呼吸窘迫症候群(RDS)、囊性腦室周圍白質軟化(cPVL)、第28天較高濃度的氧氣使用和第28天較嚴重的呼吸器使用是本研究中重要因子。而D1 – D28體重成長率對BPD的影響在極度早產兒中更為明顯。
透過了解早產兒的成長軌跡與BPD之關聯性，有助於早期發現高風險之早產兒並提前介入，以降低BPD的發生率和嚴重程度。

Bronchopulmonary dysplasia (BPD) is a respiratory disorder that affects premature infants. In this study, the generalized linear model (GLM) was used to explore the risk factors affecting BPD, trying to understand the relationship between the growth trajectory in the first month of life and the occurrence of BPD at gestational age (GA) of 36 weeks.
This thesis employed a retrospective cohort design through the National Cheng Kung University Hospital (NCKUH) of very premature infants, and according to the definition of the National Institute of Child Health and Human Development (NICHD) workshop held in June 2000 which defined BPD status at 36 weeks GA. GLM combined prenatal and postnatal risk factors to examine the association with BPD development. This study discussed the body weight growth rate proposed in the article. Since most of the risk factors were uncontrollable, the body weight growth rate was an opportunity that may be improved through nutrition.
The results indicated that when preterm infants were male, lower GA, a lower growth rate of body weight from day 1 to day 28 (D1 – D28), respiratory distress syndrome (RDS), cystic periventricular leukomalacia (cPVL), a higher concentration of oxygen use on day 28, and more severe respirator use on day 28 the most significant risk factors in this study. However, the effect of D1 – D28 weight growth rate on BPD was more pronounced in the extremely preterm infants.
Understanding the relationship between the growth trajectory of premature infants and BPD, it is helpful to early detect high-risk premature infants and intervene in advance to reduce the incidence and severity of BPD.

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