睡眠是生命中相當重要的一部分，人一生中會用掉三分之一的生命在睡眠上，但睡眠障礙是人們最常遇到的生理問題之一，其中失眠為睡眠障礙中比例最多的一種睡眠問題，然而患有慢性失眠人口在台灣為 21.8％。另外，經過統計約有 60萬美國人在一年中有曾經失眠或長期失眠。因此，我們發展了一個手腕式活動紀錄器來偵測睡眠活動達到睡眠獲得客觀的睡眠品值之評估，因此我們也提出一個新的演算法使用於此自製的活動紀錄系統，該演算法將採用自適應視窗以適應不同的睡眠效率的受試者來平衡睡眠與清醒之間的準確率，我們錄製了35個健康的青年受試者和5個有失眠的受試者的整晚約8小時的睡眠活動訊號，並使用這些數據透過我們的演算法計算清醒-睡眠結果與多通道生理監控儀(PSG)的清醒-睡眠判讀結果做比較，結果將可以達到 91 ％的整體準確度， 92 ％的靈敏度，80 ％的明確性，97 ％的睡眠預測值與54 ％的清醒預測值，與其他已提出的活動紀錄做清醒-睡眠分析的方法相比整體提升了不少的準確度。

Sleep is an integral part of life, person will have spent one-third of the life for sleep generally, but sleep disorder is people one of the most frequently encountered of physiological problems, and insomnia is the most part of sleep disorder, the prevalence of chronic insomnia in Taiwan was 21.8%. After statistics, about 60 million Americans in a year have insomnia frequently or for extended periods of time. So we develop a wrist actigraphy and we propose a new algorithm for self-made actigraphy, the algorithm is use adaptive window size to fit different sleep efficiency and balance performance between sensitivity and specificity, we recorded 35 health young subject and 5 insomnia subject all night about 8 hours actigraphy signal for measure our algorithm with polysomnograph (PSG), the result of our algorithm is reach 91 % in overall accuracy, 92 % in sensitivity, 80 % in specificity, 97 % in predictive value for sleep and 54 % in predictive value for wake, compare with other method presented previously will higher in all of the performance.

Analog Device Inc. “ADXL335 datasheet”, http://www.analog.com/en/index.html, 2009
Blagrove M, Owens DS, MacDonald I, Sytnik N, Tucker P, Folkard S, “Time of day effects in, and the relationship between, sleep quality and movement,” J Sleep Res, 1998; 7(4):233-239.
Dagan Y, Zinger Y, Lavie P, “Acitgraphic sleep montoring in post-traumatic stress disorder (PTSD) patients,” J Psychosom Res, 1997; 42(6):577-581.
Evans BD, Rogers AE, “24-hours sleep/wake patterns in healthy elderly persons,” Appl Nurs Res, 1994; 7(2):75-83.
Frisbie JH, Sharma GVRK., "Circadian rhythm of pulmonary embolism in patients with acute spinal cord injury,” Amer J Cardiol, 1992; 70:827.
Guilleminault C, Clerk A, Black J, “Labanowski M, Pelayo R, Claman D. Nondrug treatment trials in psychophysiologic insomnia,” Ann Intern Med, 1995; 155:838-844.
Hirshkowitz M (2004). "Chapter 10, Neuropsychiatric Aspects of Sleep and Sleep Disorders (pp 315-340)". Stuart C. Yudofsky and Robert E. Hales, editors
Hauri PJ, Wisbey J, “Wrist actigraphy in insomnia,” Sleep, 1992; 15(4):293-301.
Wilson KG, Watson ST, Currie SR, “Daily diary and ambulatory activity monitoring of sleep in patients with insomnia associated with chronic musculoskeletal pain,” Pain, 1998; 75(1):75-84.
Javaheri S, Storfer-Isser A, Rosen CL, Redline-Circulation S, “Sleep Quality and Elevated Blood Pressure in Adolescents,” Am Heart Assoc, 2008; 118:1034-1040.
Jean-Louis G, Kripke D, Ancoli-Israel S, “Sleep and quality of well-being,” Sleep, 2000; 23(8):1115-1121.
Jean-Louis G, Kripke DF, Mason WJ, Elliott JA, and Youngstedt SD, “Sleep estimation from wrist movement quantified by different actigraphic modalities,” J. Neurosci. Meth., 2001, 105: 185–191.
Kohavi R and Provost F, “Glossary of terms,” Mach. Learn., 1998; 30: 271–274.
Kain ZN, Mayes LC, Caldwell-Andrews AA, Alexander GM, “Sleeping characteristics of children undergoing outpatient elective surgery,” Anesthesiology, 2002; 97:1093–101.
MacQueen J, “Some methods for classification and analysis of multivariate observations,” Fifth Berkeley Symp. on Math. Statist. and Prob., 1967; 1:281-297
Microchip, “PIC18F46J50 datasheet”, http://www.microchip.com/wwwproducts/Devices.aspx?dDocName=en539708 2009
Morin CM, "The Nature of Insomnia and the Need to Refine Our Diagnostic Criteria" (Editorial). Psychosomatic Medicine, 2000; 62 (4):483–485.
Middelkoop HA, Van Dam E, Smilde-van den Doel DA, “45-hour multiple-site actimetry in 20 healthy subjects: relations between body and limb movements and the effects of circadian sleep-wakefulness,” Sleep-Wake Research in the Netherlands, 1995; 681-684.
Middleton B, Arendt J, Stone BM, “Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time,” J Sleep Res, 1996; 5(2):69-76.
Middleton B, Arendt J, Stone BM, “Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light,” J Bio Rhythms, 1997; 12(5):467-477.
NINDS, http://www.ninds.nih.gov/
PSG “Siesta 802 User Guide.pdf”, http://www.advancedmedicalequipment.com/siesta.htm
Pollak C, Tryon WW, Nagaraja H, Dzwonczyk R, “How accurately does wrist actigraphy identify states of sleep and wakefulness,” Sleep, 2001; 24(8):957-965.
Rechtschaffen A and Kales A, “A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects,” Archives of General Psychiatry. 1969; 20(2): 246-247.
Raymond I, Ancoli-Israel S, Choinière M, “Sleep disturbances, pain and analgesia in adults hospitalized for burn injuries,” Sleep Medicine, 2004; 5:551–559
Satlin A, Teicher MH, Lieberman HR, Baldessarini RJ, Volicer L, Rheaume Y, “Circadian locomotor activity rhythms in Alzheimer’s disease,” Neuropsychopharmacol, 1991; 5(2):115-126.
Sadeh A, Sharkey KM, Carskadon MA, “Activity-based sleep-wake identification: An empirical test of methodological issues.” Sleep, 1994; 17:201-207.
Sadeh A, Hauri PJ, Kripke DF, Lavie P, “The Role of Actigraphy in the Evaluation of Sleep Disorders,” Sleep, 1995; 18(4):288-302.
Sazonov ES, Sazonova NS, Schuckers SAC, “Neuman, M. and CHIME study group. Activity-based sleep-wake identification in infants,” Physiol. Meas., 2004; 25:1291–1304.
TSSM, http://www.tssm.org.tw/
Tilmanne J, Urbain J, Kothare MV, Wouwer AV and Kothare SV, “Algorithms for sleep–wake identification using actigraphy: a comparative study and new results,” J Sleep Res. 2009 Mar;18(1):85-98.
Van Someren EJW, “Improving actigraphic sleep estimates: how many nights?” J Sleep Res., 2007; 16(3):269-275.
Wicklow A, Espie CA, “Intrusive thoughts and their relationship to actigraphic measurementof sleep: Towards a cognitive model of insomnia,” Behav Res Ther, 2000; 38:679-693.
Wirz-Justice A, Haug HJ, Cajochen C, “Disturbed circadian rest-activity cycles in schizophrenic patients: An effect of drugs,” Schizophrenia Bul, 2001; in press.
Wirz-Justice A, Quinto C, Cajochen C, Werth E, Hock C, “Arapid-cycling bipolar patient treated with long nights, bedrest, and light,” Biol Psychiatry, 1999; 45(8):1075-1077.
Wirz-Justice A, Cajochen C, Nussbaum P, “A schizophrenic with an arrhythmic circadian rest-activity cycle.” Psychiatry Res, 1997; 73:83-90.
Wirz-Justice A, Werth E, Savaskan E, Knoblauch V, Gasio PF, Muller-Spahn F, “Haloperidol disrupts, clozapine reinstates the circadian rest-activity cycle in a patient witih early-onset Alzheimer’s disease,” Alzheimer Disease and Associated Disorders, 2002; 14(4):212-215.
Yoon IY, Kripke DF, Youngstedt SD and Elliott JA, “Actigraphy suggests age-related differences in napping and nocturnal sleep,” J. Sleep Res., 2003; 12, 87–93.