根據中華民國衛生福利部統計，2015年台灣成年人糖尿病之盛行率為10.00%，在糖尿病的照護中，目標除了有效控制血糖外，更要避免第二型糖尿病引起的諸多併發症。其中糖尿病周邊神經病變盛行率在台灣更介於21%到41%的區間。糖尿病周邊神經病變造成的感覺異常，對於個人日常生活品質的影響甚鉅，因此周邊神經病變的預防、早期介入並控制惡化對於糖尿病患十分重要。糖尿病周邊神經病變主要肇因於長期高血糖導致神經失去養份供給而造成損害，現今病人多選擇服用藥物控制，然而，對於糖尿病周邊神經病變並沒有標準而真正有效的治療方法。目前相關研究皆指出，長期有氧運動可有效透過控制血糖之方式減緩糖尿病周邊神經病變進程，而在其他研究中更證實有氧運動可以降低身體的氧化壓力；另一方面，從物理治療的角度，若要改善神經灌流與受損可施作神經鬆動術，目前神經鬆動術在多篇研究中對於腕隧道症候群或腰椎神經疾患等，都已證實有顯著的效果，因此本研究合併有氧運動訓練與神經鬆動術，針對糖尿病周邊神經病變之病患治療六週，探討治療前後神經功能、與氧化壓力的變化。
本研究收入四名糖尿病周邊神經病變確診病患，編入有氧運動訓練合併神經鬆動術組，進行每週三次，共介入六週之中等強度有氧運動訓練，並在運動前，先施作雙側下肢神經鬆動術治療。受試者在治療前後都會接受評估，內容包含神經傳導速率檢查(NCV)、密西根神經病變篩檢量表(MNSI)、密西根神經病變量表(MDNS)、數字評分法(NRS)與被動直膝抬腿測試(SLR)，並且在前後測皆進行血液採樣，探討其氧化壓力指標之變化，並將這些結果加入藥物治療組(n=8)與神經鬆動術治療組(n=6)共三個組別進行分析。
研究結果顯示，在組間比較中，有氧運動訓練合併神經鬆動術組相較於藥物治療組或神經鬆動術治療組不管是對於症狀相關的SLR、MNSI、NRS，或是氧化壓力指標(SOD, MDA, 8OH-dG)皆顯示出顯著的治療效果差異(p <0.05)。在有氧運動訓練合併神經鬆動術組內比較中，MDNS、MNSI、NRS也皆有下降的趨勢，合併SLR的角度有上升趨勢，我們可以推斷有氧運動訓練合併神經鬆動術組對於糖尿病周邊神經病變的症狀方面有不錯的治療效果。然而在NCV的結果顯示，有氧運動訓練合併神經鬆動術治療前後並沒有顯著的改變，顯示該治療在神經功能上可能沒有明顯的改善效果。
本篇研究合併有氧運動訓練與神經鬆動術治療，我們推測此種治療方法可以先以神經鬆動術改善神經血液循環，在透過中等強度有氧運動訓練造成的全身性氧化壓力下降，供給神經低氧化壓力的血液，以祈達到神經修復之效果。在為期六週的治療後，縱觀各項指標之結果，雖然對於神經功能上的影響並不顯著，但是我們發現此種治療可以有效降低周邊神經病變的症狀，因此有氧運動訓練與神經鬆動術可視為未來具有相當潛力的治療方法。

In Taiwan, the Prevalence of Diabetic peripheral neuropathy (DPN) in diabetic patients is around 21% - 40%. Although there are several therapeutic choices, there is no definitive intervention for DPN. Since much research had revealed that DPN resulted from microvascular pathology. Therefore, we hypothesized that 6-week moderate aerobic exercise combined with neural mobilization (AE+NM) have positive therapeutic effect of DPN. This study included DPN patients (n=4). We had NCV, SLR, MNSI, MDNS and NRS as assessment and analyzed oxidative stress marker (SOD, MDA, CAT, 8-OHdG) in blood test before and after 6-week intervention with medication group (MED) (n=6) and neural mobilization group (NM) (n=8). The results showed that as AE+NM comparing to MED and NM, the outcome measurement like SLR, MNSI, NRS scale and oxidative stress had significant decrease. Within AE+NM, MNSI, MDNS and NRS showed a decreasing trend after intervention, increasing trend in SLR, but no change in NCV result. Therefore, we concluded that the 6-week intervention had better therapeutic effect on decrease symptoms and oxidative stress.

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