生物晶片具有多功能、反應快速、減少樣品消耗及低成本等優勢，需要可以精準控制晶片內樣品的操作。因此如何在晶片內傳輸樣品或藥物也是相當重要的一環，本論文提出一種利用磁性人工纖毛進行微流體推進之裝置，透過一個可由程式化控制之磁場驅動裝置操縱微流道內之磁性人工纖毛以 40 Hz 擺動，進行微流體的推進，並使用微粒子影像測速儀 (Micro-particle image velocimetry, μPIV) 分析流場資訊，分別針對纖毛推動機制、纖毛數量、纖毛分布及運動模式等參數作探討，並藉由這些實驗結果，用於進行裝置效能提升之策略。本研究之磁性人工纖毛以頻率 40 Hz 擺動，經由調整纖毛數量提高兩倍以上之淨流速，並可產生 15.4 μm/s 之淨流速以及 485.5 μm/s 以上之有效局部流動，並透過改變人工纖毛進行動力衝程與恢復衝程之路線，以三角形軌跡之運動模式成功地減少 56 % 的流體震盪現象。因此根據本論文研究結果，透過調整纖毛數量、分布及擺動模式之參數，可有效地增加人工纖毛應用於微流體推進之效能，本裝置可穩定地推動流體並產生有效地局部流動，未來可利用此局部流動於內皮細胞或紅血球等細胞觀察之實驗。人工纖毛除了可應用於微流體推進，亦可進行微流體混合等微流體操控，因此具有多功能操控微流體的人工纖毛，可滿足生物晶片多功能性且精準操控樣品的需求。

An artificial cilia based micropump is proposed, where a series of artificial cilia were employed that were rotating at a frequency of 40 Hz, through an external four-coil magnetic system, propels the fluid inside the microchannel. When artificial cilia traverse in a cyclic manner, the generated back flow during the recovery stroke and flow oscillation during artificial cilia actuation are inevitably significant. In order to improve the net pumping efficiency by reducing the backflow propagation and generated oscillation, the number, distribution and beating trajectory of artificial cilia inside the microchannel were optimized. It was observed that, the generated local flow speed can reach upto 485.5 μm/s with net flow speed 15.4 μm/s at a rotational frequency of 40 Hz. In addition, 56% of the flow generated due to the oscillation in the channel were eliminated by manipulating the trajectories respectively for both the power stroke and recovery stroke of artificial cilia.

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