從魚腥草全株分離得到44個化合物，其中houttuynamide A、houttuynoside A為首次發現之新化合物。其餘38個經與文獻所報導的物理與化學光譜數據進行比對，確認其結構為aristolactam BⅡ、aristolactam AⅡ、piperolactam A、3,4-dimethoxy-N-methyl aristolactam、lysicamine、splendidine、cepharadione B、norcepharadione B、noraristolodione、N-(1-hydroxymethyl-2-phenylethyl) benzamide、N-(4-hydroxyphenylethyl)benzamide、benzamide、4-hydroxybenzamide、4-hydroxy-3-methoxybenzamide、6,7-dimethyl-1-ribitol-1-yl-1,4- dihydroquinoxaline-2,3-dione、(1H)- quinolinone、indole-3-carboxylic acid、vomifoliol、dehydrovomifoliol、reseoside、7-(3,5,6-trihydroxy-2,6,6-trimethyl- cyclohexyl)but-3-en-2-one、6-(9-hydroxybut-7-enyl)-1,1,5- trimethylcyclohexane- 3,5,6-triol、quercitrin、quercetin-3-O-β-D-galactopyranoside、afzelin、vanillic acid、 methyl vanillate、vanillin、protocatechuic acid、4-hydroxybenzoic acid、methylparaben、p-hydroxybenzaldehyde、cis and trans-methyl ferulate、β-sitosteryl glucoside、β-sitosterol、cycloart-25-ene-3,24-diol。
　　其中化合物cepharanone B具有很強的抗酪胺酸酶活性。其他還有4個化合物具有DPPH所產生之自由基捕捉能力分別為quercetin-3-O-β-D- galactoside、quercitrin、vanillic acid、protocatechuic acid，其中quercitrin、quercetin-3-O-β-D- galactopyranoside對DPPH自由基捕捉能力比Vit E強。

　　Forty-four compounds were isolated from the whole plant of Houttuynia cordata Thunb. Of these, forty compounds were characterized by comprehensive analyses of their 1D and 2D NMR and mass spectra. Among them, houttuynamide A and houttuynoside A were found be new compounds. The thirty-eight known compounds were identified as aristolactam BⅡ, aristolactam AⅡ, piperolactam A, 3,4-dimethoxy-N-methyl aristolactam, lysicamine, splendidine, cepharadione B, norcepharadione B, noraristolodione, N-(1-hydroxymethyl-2-phenylethyl)benzamide, N-(4-hydroxyphenylethyl)benzamide, benzamide, 4-hydroxy benzamide, 4-hydroxy-3-methoxybenzamide, 6,7-dimethyl- 1-ribitol-1-yl-1,4- dihydroquinoxaline-2,3-dione, (1H)- quinolinone, indole-3- carboxylic acid, vomifoliol, dehydrovomifoliol, reseoside, 7-(3,5,6-trihydroxy- 2,6,6-trimethyl- cyclohexyl)but-3-en-2-one, 6-(9-hydroxy-but-7-enyl)-1,1,5- trimethylcyclohexane- 3,5,6-triol, quercitrin、quercetin-3-O-β-D-galactopyranoside, afzelin, vanillic acid, methyl vanillate, vanillin, protocatechuic acid, 4-hydroxybenzoic acid, methylparaben, p-hydroxybenzaldehyde, cis and trans-methyl ferulate,β- sitosteryl glucoside,β- sitosterol and cycloart-25-ene-3,24-diol by comparison of their physical and spectral data with those reported in the literature.
Furthermore, some of the isolated compounds were evaluated for their anti- tyrosinase and anti-oxidant activities. Cepharadione B showed the storng inhibition activity against tyrosinase. Quercitrin, quercetin-3-O-β-D-galactopyranoside,　vanillic acid, protocatechuic acid showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical- scavenging activity of which quercitrin and quercetin-3-O-β-D- galactopyranoside have the stronger scavenging activity than Vit E.

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