本實驗分成兩部份，第一部份探討高分子混摻對電紡絲纖維物理性質的影響；第二部份則為孔洞電紡絲纖維之製備。在第一部份實驗中，以聚羥基丁酸酯(PHB)製備電紡絲纖維，分別改變電壓、體積流速、溶液濃度，探討改變製程參數對纖維形態的影響。當電壓增加，會產生直徑較小且表面較粗糙的纖維；流速增加，得到直徑較大且表面粗糙之纖維；較大的溶液濃度，會產生直徑較大且表面平滑之纖維。以PHB混摻共聚物(羥基丁酸酯-羥基戊酸酯)(PHBV)製備電紡絲纖維。由SEM圖可發現，隨著混摻比例不同，會出現不同表面形態及直徑之纖維，PHBV(5% HV)之纖維，有最大的直徑而表面出現較多孔洞，PHBV(12% HV)之纖維有最小的直徑且表面光滑，並交聯成網狀結構；由DSC圖可發現，PHB混摻PHBV(12% HV)會造成熔點的下降，但混摻PHBV(5% HV)，則因PHV含量太少，使熔點沒有明顯變化，PHB成核速率隨著混摻PHBV而增加；此外，經過混摻的電紡絲纖維，不會改變結晶形態；由SAXS數據可得到，混摻PHBV後，纖維之結晶度有些微下降，比較DSC數據亦有同樣結果； PHB混摻PHBV後，會使纖維所形成的薄膜之抗拉強度增加，混摻HV含量較高之PHBV(12% HV)，抗拉強度更為提升，可增加其應用性。
第二部份實驗，將聚偏氟乙二烯(PVDF)混摻不同比例聚苯乙烯(PS)，製備電紡絲纖維，再以toluene移除PS，得到具備孔洞結構之纖維。由BET量測結果得到，當混摻纖維移除PS後，會使表面積和孔洞大小增加，當PVDF混摻分子量較低之PS(Mw~2400)時，所製備之電紡絲纖維，亦有較大的表面積和孔洞。

There are two main topics in this study. In the first part we investigated the effect of polymer blends on the physical properties of electrospun fibers. The surface morphology and diameter of electrospun fibers depend on the applied voltage, volumetric flow rate and solution concentration. From SEM image, the diameter of poly(3-hydroxybutyrate)(PHB) fiber decreases with an increase in the applied voltage, but the surface of fibers becomes rough. The thinner and the smoother fibers were obtained with the low volumetric flow rate. The fibers also became thinner and had higher roughness with decreasing solution concentration. PHB was then blended with poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) to prepare fibers. It was obtained that neat PHBV (12% HV) fibers exhibit the thinnest and smoothest structure. In contrast, the neat PHBV (5% HV) fibers are thicker and develop a pore structure on the surface. The DSC measurement showed that the melting temperature (Tm) of PHB decreases with the addition of PHBV(12% HV). However, the Tm of PHB/PHBV(5% HV) blends was nearly identical due to the low content of HV. In addition, the degree of crystallinity of blends decreases with an increase in the PHBV concentration. From the XRD analysis the crystal structure of the blends is consistent regardless of the blend composition. The mechanical properties of PHB/PHBV membrane suggest the enhancement of the fiber strength upon the addition of PHBV. Additionally, the tensile strength of PHB/PHBV(12% HV) membrane is much larger than that of PHB/PHBV(5% HV). This is attributed to the content of HV in the blends.
The second part focuses on the fabrication of the porous electrospun fibers. The poly(vinylidene fluoride)(PVDF) was electrospun to prepare nanofibers with various compositions of PS. Then PS was removed by the selective dissolving PS in toluene. The BET measurement showed that the pore size and surface area of fibers increase after PS is removed. These fibers exhibit the greater surface area and pore size when the low molecular weight PS (Mw~2400) is blended with PVDF.

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