現今社會隨著老年人口、肥胖率逐漸升高，高血糖、高血脂、高血壓、糖尿病好發率也不斷提升，這些都是慢性傷口的好發族群，如何面對慢性傷口成為未來必須面對的課題，因此本實驗選擇以水膠敷料為出發點，預期可以做出針對慢性傷口的傷口敷料。
本實驗選擇選用HEMA (2-hydroxyethyl methacrylate)和PEGDA (Poly(ethylene glycol) diacrylate)作為水膠敷料的基材和交聯劑，他們良好的生物相容性可以讓水膠敷料在接觸傷口時不影響正常的細胞運作。而在過去的研究中證實了慢性傷口中的基質金屬蛋白酶(Matrix metalloproteinase, MMP)的濃度為普通急性傷口的兩倍，此現象是影響慢性傷口癒合緩慢的重要因素之一，因此本實驗希望透過導入可以抑制MMPs活性的阿侖磷酸官能基進入水膠敷料之中，來達到治癒慢性傷口的效果。
本實驗先合成了帶有雙鍵和阿侖磷酸官能基的阿侖磷酸單體，並透過光聚合的方式將HEMA、PEGDA和阿侖磷酸單體共聚成水膠敷料，並透過SEM、膨潤性質測試、機械性質測試、MMPs活性抑制測試和細胞毒性測試來優化比例的調配，期望製作出擁有可以保持濕潤、柔軟但具韌性、具MMPs活性抑制能力並不具細胞毒性的水膠敷料。
綜合以上實驗結果分析，阿侖磷酸的導入會賦與水膠MMPs活性抑制能力並且增加膨潤性質但同時機械性質會流失，此外阿侖磷酸的導入會使得水膠具有些許細胞毒性，此問題可以由增加交聯劑的比例解決。最後H95A3不僅擁有良好的MMPs活性抑制能力也具備柔軟、具韌性、高生物相容性的特性，在所有比例中最適合做為後續針對慢性傷口水膠敷料研究的參考。

In modern society, with the gradual increase of the elderly population and obesity rate, the rate of high blood sugar, hyperlipidemia, high blood pressure, and diabetes is also increasing. These are the high-risk groups to suffer from chronic wounds. Therefore, How to deal with chronic wounds has become a must in the future.
Here, HEMA (2-hydroxyethyl methacrylate) and PEGDA (Poly(ethylene glycol) diacrylate) were selected as the base material and cross-linker of the hydrogel wound dressing due to their good biocompatibility. According to references, introduce the alendronate functional group that can inhibit the activity of MMPs into the hydrogel dressing can achieve the effect of healing chronic wounds. Therefore, we combine HEMA, PEGDA and self-synthesis alendronate monomer with 9 ratios. Then, the swelling property test, mechanical property test, structure analysis, MMPs activity inhibition test and cytotoxicity test were be done to above 9 ratios hydrogel dressing to analyze the influence of the content of the crosslinker and alendronate monomer on the properties of the hydrogel dressing.
According to the results, the H95A3 group performed well in all tests. Although the inhibitory ability of MMPs activity is not as good as that of GA10X made by Rayment et al.[1], it meets the required characteristics of wound dressings in other basic properties, and is considered the most suitable ratio in this study.
For ideal wound dressing, antibacterial ability is also an important indicator. In the future, antibacterial drugs can be added on the basis of this ratio of H95A3 to further meet the needs of chronic wound dressings.

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