先前由CMRT(Cana Material Research Team)經多年努力開發之鈣基骨泥(Calcium-Based Cement,CBC)具有優越的操作性、物化性質、生物相容性及骨引導性。而為了進一步降低在牙科及骨科手術上遭受細菌感染的風險，一般的應對方式是施予患者抗生素以抑制細菌的生長，但抗生素卻容易使細菌產生抗藥性以及容易對人體造成負擔等副作用。有鑒於此，本實驗室開始以添加抗菌因子至骨水泥中做為研究方向。抗菌因子A長期用於牙科，其可釋放鹼性使周圍環境pH快速升高以抑制細菌的生長，其釋放之離子也有研究指出可以刺激骨細胞分泌骨質。因此本研究選擇以抗菌因子A為添加至CBC的抗菌因子。
在前期研究中，直接添加抗菌因子A細粉至CBC所得到的抗菌骨泥性質並不理想；其中，當此抗菌骨泥浸泡至人工體液時，會因抗菌因子A快速溶解釋出離子而與人工體液中之離子產生大量析出物，為了避免析出物可能於未來植入時有造成血管栓塞的風險，開始進行抗菌因子A粉末的改質與後續添加至CBC的研究。
研究成果發現，將抗菌因子A與粉末H與純水混合、加壓成形後而得之A-D複合物，加入CBC後可以有效改善先前大量析出物生成的問題，並且搭配適當的液粉比可以有良好的注射性與崩解性，在24小時也可提供足夠的抗壓強度。在生物實驗方面，擁有良好抗菌性。

The calcium phosphate/calcium sulfate composite developed by CMRT(Cana Materials Research Team) has a excellent physical properties, chemical properties and biocompatibility. Generally, antibiotics are added to bone substitute to decrease the postoperative infection rate.
In our study, we chose substance A as the antibacterial addictive. We found that the addition of substance A though enhanced the antibacterial capacity, it produced white precipitation in SBF (Hanks’ solution and PBS).Such precipitation may cause thrombosis. To solve this problem, we try to modify particle size by binding substance A powder and powder-H to become a composite particle to lower the dissolution rate of substance A. The results showed that the addition of the composite particle do not produced precipitation in SBF. By the way, it also attains enough mechanical strength without dispersion. In the aspect of biology, it not only got enough antibacterial capacity, but also good biocompatibility proved by cytotoxicity experiments.

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