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研究生： 黃冠智
Huang, Guan-Jhih
論文名稱： 硫酸鈣做為骨取代物材料之初步探討
Evaluation of calcium sulfate used as bone substitute material
指導教授： 陳瑾惠
Chern, Jiin-Huey
朱建平
Ju, Chien-Ping
學位類別： 碩士
Master
系所名稱： 工學院 - 材料科學及工程學系
Department of Materials Science and Engineering
論文出版年： 2013
畢業學年度： 101
語文別： 中文
論文頁數： 95
中文關鍵詞： 硫酸鈣 、骨水泥 、生物降解
外文關鍵詞： calcium sulfate, bone cement, biodegradation
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    • 硫酸鈣應用在填補骨骼缺陷之醫療用途可回溯至十九世紀末。硫酸鈣在人體內具有良好的生物相容性而且在植入人體後，不會有血鈣的現象，併發症甚至沒有任何感染，硫酸鈣促進骨再生的性質更大大的增加了硫酸鈣應用在骨取代物可看性，但是缺點就是硫酸鈣在生物體內的生物降解性太快，很快就會被人體吸收。所以本實驗嘗試製造硫酸鈣顆粒，以硫酸鈣粉末比硫酸鈣顆粒為X比Y的比例混和，為本實驗所測試的硫酸鈣骨水泥(X/Y硫酸鈣)。期望藉由硫酸鈣顆粒的添加使硫酸鈣骨水泥的降解速率減緩，進而製造出可控制降解速率又有良好操作性質、崩解性質、注射性質的硫酸鈣骨水泥。

    That calcium sulfate used in medical applications to fill bone defects can be traced back to the nineteenth century. In the human body calcium sulfate bone cement has good biocompatibility .When it’s implanted in the human body, there will be not the phenomenon of hypercalcemia syndrome, complications, and even without any infection. Facilitating bone regeneration is a one of the most important features of calcium sulfates, and such importance will make bone substitutes more applicable in the future. However, the drawback is that calcium sulfates degrade rapidly in vivo, in other words, it will soon be absorbed. In this study, calcium sulfate dihydrate as a raw material is tried to fabricate calcium sulfate granules. And then by mixing a certain proportion of calcium sulfate hemihydrate powder and calcium sulfate granule, we can fabricate a calcium sulfate bone cement that has appropriate degradation rate, handleability, and injectability.

    中文摘要 I Abstract II 誌謝 III 總目錄 IV 表目錄 VIII 圖目錄 IX 第一章 總序論 1 1-1 生醫材料的定義與簡介 1 1-2 生醫材料的分類 4 1-2-1金屬材料（metal） 4 1-2-2陶瓷材料（ceramic） 5 1-2-3高分子材料（polymer） 7 1-2-4複合材料（composite） 9 1-3生醫陶瓷種類 12 1-3-1生物惰性陶瓷（Bioinert ceramics） 12 1-3-2生物活性陶瓷(Bioactive ceramics) 13 1-3-3可吸收性生醫陶瓷（Resorbable bioceramics） 13 1-4骨水泥的簡介 17 1-4-1 骨取代材的性質及製程要求 17 1-4-2 骨水泥的定義 18 1-4-3理想骨水泥的要求 18 1-6生醫材料發展簡史 23 第二章 文獻回顧 27 2-1醫用硫酸鈣發展歷史 27 2-2硫酸鈣的相轉換機制 29 2-3硫酸鈣的煆燒特性 33 2-4 α與β半水硫酸鈣特性的比較 35 2-4-1 α與β半水硫酸鈣製造方法 35 2-4-2 α與β半水硫酸鈣的性質差異 35 2-4-3 α與β半水硫酸鈣的水合硬化過程 37 2-5硫酸鈣的作用機制 38 2-5-1脫水機制的分子觀 39 2-5-2硫酸鈣脫水的化學方程式 39 2-5-3結晶結構的影響 40 2-6粉液混合過程對反應的影響 43 2-6-1不同添加劑與硫酸鈣結晶過程的影響 43 2-6-2不同液粉比對硫酸鈣性質的影響 45 2-7磷酸根對二水硫酸鈣生成反應的影響 48 2-8硫酸鈣在生醫材料上的應用 51 2-8-1有添加硫酸鈣的多相複合生醫材料 51 2-8-2硫酸鈣在骨移植術上的應用 54 2-8-3硫酸鈣促進骨再生機制 55 2-9硫酸鈣作為骨水泥的優勢 58 2-10研究目的 60 第三章 實驗原理及步驟 61 3-1 實驗步驟 61 3-1-1製作硫酸鈣顆粒 61 3-1-2硫酸鈣粉末/硫酸鈣顆粒複合材的製作與測試 61 3-2 實驗分析方法 63 3-2-1 崩解性質的測試 63 3-2-2 工作與硬化時間測量 65 3-2-3 抗壓試片製作與強度測試 66 3-2-4 pH值的量測 67 3-2-5 X-Ray diffraction（XRD）分析 68 3-2-6 Scanning Electron Microscopy（SEM）表面觀察 69 3-2-7 孔隙度（Porosity）測試 71 3-2-8 重量損失的量測 72 3-2-9 細胞毒性測試 (Cytotoxicity test) 72 第四章 結果與討論 75 4-1 浸泡人工體液後，X/Y硫酸鈣跟對照組性質比較 75 4-1-1 XRD繞射分析 75 4-1-2 抗壓強度測試 76 4-1-3 孔隙率和重量損失測試 78 4-1-4 pH值量測 81 4-1-5 掃描式電子顯微鏡(SEM)表面型態分析 82 4-2細胞毒性測試 87 第五章 結論 89 參考文獻 90

    Amathieu L. and R. Boistelle, "Crystallization Kinetics of Gypsum from Dense Suspension of Hemihydrate in Water, " Journal of Crystal Growth 88: 184,1988.
    Amathieu L. Boiste R.: lle, J. Crystal Growth 79: 169, 1986.
    Breed AL. "Experimental production of vascular hypotension, and bone marrow and fat embolism with methylmethacrylate cement." Traumatic hypertension of bone. Clin Orthop 102: 227-44, 1974.
    Brown WE, Chow LC. "A new calcium phosphate water-setting cement. " In: Brown PW, editor. Cements research progress 1986. Westerville, OH: Am Ceram Soc;. p 352–379. 1987
    Buchardt H “"The biology of bone graft repair. " Clinical Orthop 174: 28-42, 1983.
    Chunjuan Gao, Jianping Gao, Xiudong You, Shujuan Huo, Xiulan Li, Yang Zhang, Wenhai Zhang. "Fabrication of calcium sulfate/PLLA composite for boneRepair. " J Biomed Mater Res 73(A): 244–253, 2005.
    Combe E.C. Smith D.C., Appl J. Chem. 14: 544, 1964.
    Combe E.C. Smith D.C., Appl J. Chem. 15: 367, 1965.
    Combe E.C. Smith D.C., Appl J. Chem. 16: 73, 1966.
    Carlson J. Nilsson M. Fernandez E. Planell J.A. "An ultrasonic pulse-echo technique for monitoring the setting of CaSO4-based bone cement." 2002.
    Carlson J. Nilsson M. Fernandez E. Planell J.A. "Planell,Monitoring the Setting of Injectable Calcium-BasedBone Cements Using Pulse-Echo Ultrasound." 2002.
    Elisabeth Badens, Stephane Veesler, Roland Boistelle. "Crystallization of gypsum from hemihydrate in presence of additives." Journal of Crystal Growth 99: 704-709, 1999.
    EL-SHALL H., RASHAD M.M. ABDEL-AAL E.A. "Effect of phosphonate additive on crystallization of gypsum in phosphoric and sulfuric acid medium." Cryst. Res. Technol. 37(12): 1264–1273, 2002.
    Henman P, Finlayson D. Ordering allograft by weight: "Suggestions for the efficient use of frozen bone-graft for impaction grafting. " J Arthroplasty. 15: 368-371, 2000.
    Hench LL. Bioceramics: from concept to clinic. J Am Ceram Soc 74: 1487-1510, 1991.
    Hulbert SF, Hench LL, Forbers D, Bowman LS. "History of bioceramics. " Ceram Internat 8: 131-140, 1982.
    Hu RW, Bohlman HH. "Fracture at the iliac bone graft harvest site after fusion of the spine. " Clin Orthop. 309: 208-213, 1994.
    Jonck LM, Grobbelaar CJ. "The biological compatibility of glass ionomer cement in joint replacement." Clin. Mater.; 4: 85-107, 1989.
    Jarcho M. "Calcium phosphate ceramics as hard tissue." Clin. Orthop. Rel. Res. 157: 259-279, 1981.
    Kokubo T. "Recent progress in glass-based materials for biomedical applications." The Centennial Memorial Issue of The Ceramic Society of Japan 99: 965-973, 1991.
    Kuznetsova L.F. and O.I. Lomovskii, "Thermal Breakdown of Gypsum Crystals." Inorganic Materials 21: 1534-1536, 1985.
    Katthagen B.D. "Bone regeneration with bone substitutes", Springer-Verlag, Berlin, 1987.
    Lewry A.J. and J. Williamsoon, "The setting of gypsum plaster partIII the effect of additives and impurities."J of materials science. Vol 29, p6085~6090, 1994.
    McConnell J.D.C. Astill D.M. and Hall P.L. "The Pressure Dependence of the Dehydration of Gypsum to Bassanite. Mineralogical Magazine." 51: 453-457, 1987.
    Mongiorgi R and Krajewski A. "Mineralogical alterations in osteoporotic bone tissue structure." Biomaterials. 2: 147-151, 1981.
    Nilsson M. Ferna´ndez E. Sard S. Lidgren L. Planell1J.A. "Characterization of a novel calcium phosphate/sulphate bone cement." 2001
    Nussbaum DA, Gailloud P, Murphy K. "The chemistry of acrylic bone cements and implications for clinical (c1)use in image-guided therapy. J Vasc Interv Radiol 15:121–126, 2004.
    Nilsson M., Ferna´ndez E. Sarda S. Lidgren 1L., Planell J.A. "Characterization of a novel calcium phosphate/sulphate bone cement." J Biomed Mater Res 61: 600–607, 2002.
    Nilsson M., Wielanek L., J.S. Wang, K. E. Tanner, L. Lidgren. "Factors Influencing the Compressive Strength of an Injectable Calcium Sulfate-Hydroxyapatite Cement." Journal of Materials Science: Materials in Medicine 14: 399-404, 2003.
    P. Vincenzini, "Ceramics in sub-stitutive and reconstructive surgery." Elsevier Science Publishers B.V, 1991.
    Park JB. Biomaterials, An Introduction. Plenum Press. New York, 1979.
    Park JB. Biomaterials Science and Engineering. Plenum Press. New York and London, 1985.
    Pierson AP, Bigelow D & Hamonic M Bone grafting with boplant. Results in thirty-three cases. J Bone & Joint Surg 50(B): 364–368, 1968.
    Peltier L.F. and Jones R.H. "Treatment of unicameral bone cysts by curettage and packing with plaster of Paris." J.Bone Jt. Surg, vol 60, p820~822, 1978.
    Peltier L.F. "The use of plaster of Paris to fill defects in bone." Clin. Orthop. Vol21, p1~29, 1961.
    Ralph W.G. Wyckoff. Crystal Structures 504-507, 643-644, 1981.R. A. KUNTZE. Nature (London) 211: 406, 1966.
    Rateitschak KH, Wolf HF. "Color Atlas of Dental Medicine. Thieme Medical Publishers." 1995.
    Rashad M.M. Baioumy H.M. and Abdel-Aal E. A. "Structural and spectral studies on gypsum crystals under simulated conditions of phosphoric acid production with and without organic and inorganic additives Cryst." Res. Technol. 38(6): 433 – 439, 2003.
    Roy D.M. Linnehan S.K., "Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange. " Nature 247: 220-222, 1974.
    Soballe K. "Hydroxyapatite ceramic coating for bone implant fixation." ACTA Orthopaed Scandin Supplem 64: 1-58, 1993.
    Tadros M.E. Mayes I. Colloid J. Interface Sci. 72: 245, 1979.
    Verlaan JJ, Oner FC, Slootweg PJ, Verbout AJ, Dhert WJ Histologic changes after vertebroplasty. J Bone Joint Surg [Am] 86(A):1230-1238, 2004.
    Vincenzini P. Elsevier,Ceramics in Clinical Applications. Amsterdam-oxford-New York-Tokyo.3-27, 1987.
    van Rosmalen G.M., Daudey P.J. and Marchee W.G.J.. "Quantitative Description of the Influence of the Inhibitor Concentration on the Growth Rate of Calcium Sulfate Dihydrate Crystals in Suspension." Industrial Crystallization 81: 147-154, 1982.
    Weijnen M.P.C. and van Rosmalen G.M. "The Role of Additives and Impurities in the Crystallization of Gypsum." Industrial Crystallization 84, edited by S.J. Jancic and E.J. de Jong, Elsevier Science Publishers B.V. Amsterdam, 61-66, 1984.
    Weijnen M.P.C. and van Rosmalen G.M. "The Role of Additives and Impurities in the Crystallization of Gypsum." Industrial Crystallization 84, edited by S.J. Jancic and E.J. de Jong, Elsevier Science Publishers B.V. Amsterdam, 61-66, 1984.
    Weijnen M.P. van Rosmalen G.M. Desalination 54: 239, 1985.
    Weijnen M.P.C. and van Rosmalen G.M. "Adsorption of Phosphonate on Gypsum crystals." J. Crystal Growth. 79: 157-168, 1986.
    William R. Moore, Stephen E. Graves, GegoryiI. Bain. "Synthetic Bone Graft Substitutes." ANZ J. Surg 71: 354–361, 2001.
    www.gec.jp/CTT_DATA/WMON/CHAP_4/html/Wmon-094.html
    Ying. "Nanocrystalline apatites and composite prostheses incorporating them, and method for their production." US patent 6013591, 2000.
    汪建民, 材料分析, 中國材料科學學會, 49, 122, 1998
    林育弘, “硫酸鈣材料對於骨組織修補的應用.” 化工資訊與商情月刊第4期(92年10月號)
    周邦彥, “骨科生醫材料之發展與應用.” 技術與訓練27卷4期, 163-171,2002.
    張炳龍, ROSS 組織學, 合記圖書出版社, 147-158, 1991.
    梁智仁, “骨質疏鬆致骨折專治生物材料的研製與市場化.” 京港學術交流第五十四期, 2002
    梁繼文, 礦物學, 五南出版社, 1984
    黃喜麟, “燃煤電廠脫硫石膏轉化半水石膏之研究.” 1999
    經濟部陶瓷技術手冊Chap.31

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