化學動力療法（chemodynamic Therapy, CDT）的效果常受限於腫瘤組織中內源性過氧化氫(H2O2)濃度不足，進而限制羥基自由基的(·OH)生成效率。為解決此問題，本研究透過陽離子摻雜策略，有效促進鈷鐵普魯士藍（Co–Fe Prussian Blue, CFPB）的水驅動連續反應（H2O→O2→H2O2→·OH），顯著增強活性氧物種（reactive oxygen species, ROS）的生成。
本實驗利用沉澱法在冰浴條件下合成出鈷鐵普魯士藍奈米粒子(Co-Fe Prussian blue, CFPB)，接著利用自發性吸附反應將鹼金屬離子(Li⁺、Na⁺、K⁺、Rb⁺、Cs⁺）引入CFPB，形成CFPB/A（A = Li、Na、K、Rb、Cs）。Rb⁺與Cs⁺摻雜之CFPB可有效增強O2 → H2O2以及H2O2 → ·OH兩項還原反應；其中，Cs⁺摻雜組別觀察到明顯的Fe3+還原，進而提高結構中Co2+–NC–Fe2+的比例，顯著增強CFPB/Cs所產生的·OH量，為未摻雜之對照組的47倍。此外，密度泛函理論（density functional theory, DFT）計算則進一步驗證，隨著鹼金屬摻雜數量增加，材料的還原能力隨之提升。總結而言，本實驗透過鹼金屬摻雜方法來促進·OH的生成，預期能在化學動力療法中展現良好的治療結果。

In this study, alkali metal cations (Li⁺, Na⁺, K⁺, Rb⁺, Cs⁺) were introduced into cobalt–iron Prussian blue (CFPB) nanoparticles via a simple absorption process. Experimental results revealed that CFPB exhibited the highest adsorption capacity for Cs⁺. Moreover, the insertion of Cs⁺ induced the reduction of Fe3+ to Fe2+, thereby increasing the proportion of Co2+–NC–Fe3+ configurations, which in turn enhanced the Fenton-like reaction. Further analysis using density functional theory (DFT) calculations and projected density of states (PDOS) confirmed that the improved reductivity primarily originated from the increased number of incorporated cations. As a result, CFPB/Cs generated ·OH radicals at levels 47 times higher than undoped CFPB. This study presents a novel concept of tuning catalytic activity through alkali metal doping, offering a promising strategy for future applications in cancer therapy.

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