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研究生: 許芳瑜
Hsu, Fang-Yu
論文名稱: 探討記憶提取後造成遺忘的機制
Investigating the Mechanisms of Memory Loss After Retrieval
指導教授: 姜學誠
Chiang, Hsueh-Cheng
學位類別: 碩士
Master
系所名稱: 醫學院 - 藥理學研究所
Department of Pharmacology
論文出版年: 2025
畢業學年度: 113
語文別: 中文
論文頁數: 50
中文關鍵詞: 果蠅記憶提取測試效應提取引發遺忘
外文關鍵詞: Drosophila, memory retrieval, testing effect, retrieval induced forgetting
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  • 中文摘要 I 英文延伸摘要 III 縮寫檢索表 VIII 致謝 IX 第壹章 緒論 1 1.1記憶的形成 1.2測試效應 (testing effect) 與提取引發遺忘 (Retrieval Induce Forgetting, RIF) 1.3 果蠅做為學習記憶的模式生物 1.4 研究目標 第貳章 材料與方法 6 2.1 行為實驗 2.2 數據結果分析 2.3 化學藥物及果蠅株 第參章 實驗結果 10 3.1 建立重複提取的行為實驗模型 3.2 CS+與CS-在記憶提取與更新中的角色 3.3 探討提取後再鞏固的記憶形式:ARM或ASM? 3.4 輕微提示可喚回長期記憶重複提取後造成的遺忘 3.5 重複提取後的記憶於蕈狀體儲存的動態變化 3.6調控記憶表達與抑制的MBONs迴路 第肆章 討論 16 4.1 重複提取後的記憶遺失可以再次被喚回 4.2探討記憶抑制的觸發事件與CS+/CS-的角色 4.3 提取後的記憶轉變為不穩定的麻醉敏感狀態 (ASM) 4.4 蕈狀體在記憶表達與抑制中的角色 4.5調控記憶表達與抑制的MBON迴路與動態變化 4.6 結論 第伍章 圖表 22 第陸章 參考文獻 34

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