調幅聲為日常生活所需之溝通訊號中的重要基石之一，而這溝通訊號也包括了語言。聽覺皮層是處理調幅聲的重要中心，然而皮層中樞
如何處理調幅聲的細節(包括了皮質大腦對調頻聲音反應的閥值、處理調頻聲所需之潛伏期反應時間、皮質對調頻聲反應的變化度、頻率跟隨反應以及其對頻譜反應的特性等)目前仍尚未非常清楚。在此實驗中，我們使用一種新型的和正弦調幅音(chirp tone with sinusoidal amplitude modulation)刺激清醒大鼠的皮層誘發電位並藉由事先埋入的電極記錄。事件相關電位(ERP)和事件相關頻譜擾動(ERSP)為主要分析皮層反應的依據。相較於瞬時的聲音(click)，調幅聲所誘發的頻率跟隨反應顯示了在調幅頻率約為60 Hz時有最佳的反應，且有比較高的反應閥值(比click高出約40 dB)；在伽馬波段的反應也主要集中於200 Hz以下，且有較長的潛伏期反應時間(約23 ms)。藉由調幅聲所誘發的反應時間長於文獻報告中所指出的皮層對瞬時聲音反應時間之結果，顯示了我們所記錄到的調幅聲誘發反應發生的位置於聽覺皮層而非皮層下起源。另外，適應性濾波的應用可幫忙檢視單一試驗反應間的變異性，結果顯示了相當大的變異性存在於單一試驗反應。值得注意的是，相較於事件相關電位，事件相關頻譜擾動對於調幅聲載波頻率有較佳的選擇性，暗示了記錄電極位於較敏感的頻率位置附近(tonotopic map)。以上的結果顯示了伽馬波段的反應對於檢視聽覺皮層如何處理調幅聲是一個好的度量方法。

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