由於科技快速的發展及生活品質的提升，使得人們對健康的議題逐漸重視，在交通的進步下反而致使細菌傳播更加嚴峻，交叉感染的人數逐年上升，因此近年對於抗菌材料的需求相對提高。聚氨酯（Polyurethane）良好的機械性質與生物相容性，使得其在生醫材料方面擁有廣大的應用，但由於其表面呈現疏水性質，容易造成細菌的沾黏而造成傳遞的媒介，使得感染範圍因其擴大。
本研究計畫合成一帶有雙鍵抗菌性單體，其屬鹵胺類型抗菌劑，擁有廣譜的抗菌能力與特殊的再生性質，後續透過表面起始聚合的方式賦予聚氨酯抗菌能力，另外聚合親水性單體，增加表面的親水性質，提高氯化能力也降低細菌的沾附程度，並探討接上不同親水性單體時所呈現的結果。透過高解析核磁共振光譜儀(NMR)、高解析電子能譜儀（XPS）、高解析場發射式掃描式電子顯微鏡（HR FE-SEM）、傅里葉轉換紅外光譜（ATR-FTIR）及靜態接觸角（WCA）分析改質表面型態、表面鍵結、表面元素組成、表面親疏水性，最後透過碘量法分析氯含量以及殺菌實驗：塗盤定量評估此材料抗菌能力。
綜合各實驗結果分析確定於聚氨酯表面上改質成功，表面性質皆有明顯的變化，包括：表面的型態、鍵結的改變、元素組成的比例…等，且表面呈現親水性質，氯化後對於革蘭氏陽細菌與革蘭氏陰性菌都能達到良好的效果，成功製備出具有抗菌的聚氨酯薄膜。

Polyurethane (PU) is a biopolymer that has been commonly used in biomedical application. However, its intrinsic hydrophobic surface suffering from bacteria adhesion is one of the crucial problems that limit its applications. Among the antimicrobial agents, extensive research on N-halamine has been reported in recent years due to their superior antimicrobial efficacy against a broad spectrum, long-term stability and rechargeable properties upon exposure to household bleach. Therefore, in this work, N-halamine was synthesized for surface modification of polyurethane to achieve antimicrobial application.
In this work, a polymerizable N-halamine was synthesized and analyzed by NMR. Active functional groups were generated on PU substrates by atmospheric plasma treatment, to immobilize the initiator of surface-initiated atom transfer radical polymerization (SI-ATRP). Then, three kinds of hydrophilic polymer and N-halamine polymer were grafted on the PU substrates through sequential SI-ATRP. The surface characterization was analyzed by EDS, ATR-FTIR, WCA and XPS. After chlorination with chlorine bleach, the antimicrobial efficacies were evaluated against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) according to JIS Z 2801 method.
Results showed that three kinds of hydrophilic polymer and N-halamine polymer were grafted on PU substrate successfully and improve the chlorination efficacy since wettability increase. All the N-halamine modified PU substrates caused more than 2 log CFU reduction of bacteria reduction, however, the ones without hydrophilic polymer showed less antimicrobial efficacy.

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